[OT] Scientists Find a Soup of Suspects While Probing Milk's Link to Cancer

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Scientists Find a Soup of Suspects

While Probing Milk's Link to Cancer

By Janet Raloff

Science News, March 28th, 2009; Vol.175 #7 (p. 5)

Latest studies focus on estrogens, androgens

and IGF-1B

" Got milk? Adults who answer yes may face a

slightly heightened risk of cancer. Some

emerging data may help scientists figure out why. "

" But a new study by researchers at the National

Cancer Institute at Frederick, in land, offers

some ammunition. "

" Veenstra and his colleagues assayed

grocery-store milk for 15 estrogens: estrone,

estradiol and 13 metabolic derivatives of these

female sex hormones. "

" Estrogens can fuel the growth of many tumors,

even in the prostate--and estrogen can do this

at amazingly tiny concentrations. Identifying

how estrogens' prevalence varies by milk type,

and in what chemical form the hormones occur,

required a new assay, which the NCI scientists

describe in an upcoming issue of the Journal

of Chromatography B. "

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" One of the most provocative aspects of the milk

story is its impact on insulinlike growth factor 1.

Many studies have linked elevated concentrations of

IGF-1 with cancer risk. Not only is milk a rich

source of the substance, but people who drink milk

also end up with more IGF-1 in their blood. "

" 'We showed that IGF-1 can completely take the

place of growth hormone' in breast tissue,

Kleinberg says. In other words, IGF-1 can trigger

cell growth without an outside cue. "

" In the February Endocrine Reviews, Kleinberg

and his colleagues note that when an excess of

IGF-1 or estrogen occurs in the presence of the

other, breast hyperplasia occurs-essentially

cell division on overdrive. "

Full story

http://www.sciencenews.org/view/generic/id/41720/title/Scientists_find_a_soup_of\

_suspects_while_probing_milk%E2%80%99s_link_to_cancer

or

http://tiny.cc/Y5TFm

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