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Hypermethylation of the Calcitonin Gene in Blood Cancers

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Hua Xi Yi Ke Da Xue Xue Bao 2001 Mar;32(1):86-8

[study on hypermethylation of the calcitonin gene in malignant

hematological disorders]

[Article in Chinese]

Tang Y, Deng C, Du Q, Li G.

Department of Hematology, Sichuan Provincial People's Hospital,

Chengdu 610072, China.

OBJECTIVE: To investigate the clinical significance of

hypermethylation of the calcitonin (CT) gene in malignant

hematological disorders (MHD).

METHODS: Polymerase chain reaction (PCR) in combination with

digestion of DNA with Hpa II was used to examine the methylation

patterns of the CT gene in 73 patients with MHD, 6 healthy people and

24 patients with nonmalignant hematological disorders (NON-MHD).

RESULTS: Hypermethylation of the CT gene occurred in 12 of 14 (85.7%)

patients with acute lymphoblastic leukemia (ALL), 9 of 15 (60%) acute

nonlymphocytic leukemia (ANLL), 8 of 10 (80%) chronic myelogenous

leukemia (CML), 5 of 15 (33.3%) malignant lymphoma (ML), 2 of 5

patients with myelodysplastic syndrome (MDS), 1 of 2 malignant

histiocytosis (MH), 1 of 3 chronic lymphocytic leukemia (CLL) and 1

of 9 multiple myeloma (MM). However, it did not occur in normal

controls and NON-MHD.

CONCLUSION: Hypermethylation of CT gene may serve as an important

molecular maker for tumorous cell clone and may be useful in

diagnosing MHD, monitoring minimal residual disease and predicting

prognosis.

PMID: 12733364 [PubMed - in process]

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