Angiogenesis Review in Nature

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Full-text review on angiogenesis (the growth of blood vessels to

support tumor growth).

From Karl's nhl-info list:

Conclusion:

The three transgenic mouse models described here display a similar

pattern of the switch to persistent angiogenesis during tumor

development. Their analysis throughout multistep tumorigenesis

showed that angiogenesis was activated in the mid-stage lesions.

When taken together with the effects of angiogenesis inhibitors,

these observations indicate that angiogenesis is a prerequisite for

the rapid clonal expansion associated with the formation of

macroscopic tumors.

The balance of angiogenesis activators and inhibitors in different

tissues and their tumors may differ. It is already clear different

types of tumor cells use distinct molecular strategies to activate

the angiogenic switch. In the mouse models of multistage

tumorigenesis, distinct antiangiogenic drugs are effective at

different levels during tumorigenesis, ranging from the early onset

of angiogenesis to its continuation in end-stage cancer.20

www.nature.com/leu/journal/v21/n1/full/2404402a.html