TP53 Mutations are infrequent in newly diagnosed chronic lymphocytic leukemia

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BlankTP53 Mutations are infrequent in newly diagnosed chronic lymphocytic

leukemia.

N Zainuddin, F Murray, M Kanduri, R Gunnarsson, KE Smedby, G Enblad, J

Jurlander, G Juliusson, and R Rosenquist

Leuk Res, September 24, 2010; .

Department of Oncology, Radiology and Clinical Immunology, Uppsala University,

Uppsala SE-751 85, Sweden.

TP53 mutations in the absence of 17p-deletion correlate with rapid disease

progression and poor survival in chronic lymphocytic leukemia (CLL). Herein, we

determined the TP53 mutation frequency in 268 newly diagnosed CLL patients from

a population-based material. Overall, we detected TP53 mutations in 3.7% of

patients (n=10), where 7/10 cases showed a concomitant 17p-deletion, confirming

the high prevalence of TP53 mutation in 17p-deleted patients. Only 3 (1.1%) of

the newly diagnosed patients in our cohort thereby carried TP53 mutations

without 17p-deletion, a frequency that is much lower than previous reports on

referral cohorts (3-6%). Our findings imply that TP53 mutations are rare at CLL

onset and instead may arise during disease progression.

PMID: 20870288