Hypogammaglobulinemia (hypogam) in patients receiving Rituxan Maintenance

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Hypogammaglobulinemia (hypogam) in patients receiving Rituxan and the impact

of Rituxan maintenance http://bit.ly/cYmqll

We identified 215 pts treated with R for lymphoma between 12/1998 and 4/2009

and also had quantitative serum immunoglobulin levels (sIg) evaluated prior

to and after treatment with R. Data on the use of IVIG was collected

Rituxan was associated with developing hypogam in 39% of pts with normal

baseline sIg. Pts receiving RM (Rituxan maintenance) had a significantly

higher risk of developing hypogam and requiring IVIG. The risk of

symptomatic hypogam should be considered in the use of R maintenance.

All the best,

~ Karl

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