Vaccine Design for CD8 T Lymphocyte Responses

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BlankVaccine Design for CD8 T Lymphocyte Responses

1.. A. Koup and

2.. C. Douek

+ Author Affiliations

1.. Immunology Laboratory, Vaccine Research Center, National Institute of

Allergy and Infectious Diseases, National Institutes of Health, Bethesda,

land 20892

1.. Correspondence: rkoup@...

Abstract

Vaccines are arguably the most powerful medical intervention in the fight

against infectious diseases. The enormity of the global human immunodeficiency

virus type 1 (HIV)/acquired immunodeficiency syndrome (AIDS) pandemic makes the

development of an AIDS vaccine a scientific and humanitarian priority. Research

on vaccines that induce T-cell immunity has dominated much of the recent

development effort, mostly because of disappointing efforts to induce

neutralizing antibodies through vaccination. Whereas T cells are known to limit

HIV and other virus infections after infection, their role in protection against

initial infection is much less clear. In this article, we will review the

rationale behind a T-cell-based vaccine approach, provide an overview of the

methods and platforms that are being applied, and discuss the impact of recent

vaccine trial results on the future direction of T-cell vaccine research.