Guest guest Posted January 7, 2009 Report Share Posted January 7, 2009 The bottom line is that no one knows. The idea is to attach nanoparticles to a monoclonal antibody that will in turn attach to the CLL cells. No such monoclonal antibody exists that attaches only to CLL cells. Instead, they'd attach to B lymphocytes, much as rituximab does. Perhaps the kill rate would be higher, since the heat generated is on the order of 600 degrees. There would be no 'drug' resistance to this procedure, since no cell can build up a tolerance to such a high temperature. Radio frequency ablation (killing) is an accepted method to kill large tumors found in the kidney and elsewhere, and has a high rate of effectiveness. On caveat is that nanoparticles have their own safety concerns. For example, it has been reported that nanoparticles of zinc, used in sunscreens, can travel to the brain and kill brain cells. For that reason, I don't use sunscreens with any nanoparticles. I think it potentially is a very serious side effect (obviously). It would have to be proven to me that this would not happen. I don't know the results on the CLL cells. The process was originally proposed for solid tumors only, but testing on CLL cells (the kind of cancer Mr. Kanzius has) may mean they could use it in that 'good' cancer. It is projected that, if all goes well (and what does???), human testing could begin in two years. > > To All - > > Does anyone have more information about a pilot study being done in > Pennsylvania using blood samples from 10 CLL patients? > > There is also ongoing research at M D in Texas. > > What is the general opinion about this treatment's potential ? > > Thanks. > > --Bill > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 8, 2009 Report Share Posted January 8, 2009 I had a radio frequency ablation procedure performed on my heart in 1995 at the University of Calfiornia at San Diego hospital, used to kill three areas in my heart. Of course, a monoclonal antibody was not required for that procedure. In any event, the procedure was very precise and entirely sucessful. I had no down-time, with the exception of recovery from the sedation. The procedure beautifully replaced what once required open heart surgery - which I doubt provided equally excellent results. I expect that if the Kanzius device works for cancer, it will work better for some than others. I'm watching, as I expect many others are, as well. Warm wishes, Jan Quote Link to comment Share on other sites More sharing options...
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