Molecular Abnormalities in Coexisting CLL, MM

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Cancer Genet Cytogenet. 2004 Jan 1;148(1):44-48.

Molecular cytogenetic abnormalities in patients with concurrent

chronic lymphocytic leukemia and multiple myeloma shown by interphase

fluorescence in situ hybridization: evidence of distinct clonal

origin.

Chang H, Wechalekar A, Li L, Reece D.

Department of Laboratory Hematology, Princess Margaret Hospital and

University Health Network, University of Toronto, 610 University

Ave., 4-320, M5G 2M9, Toronto, ON, Canada

The coexistence of chronic lymphocytic leukemia (CLL) and multiple

myeloma (MM) is rare, and there is no consensus about the clonal

relationship of the two disorders when they occur in the same

individual.

We investigated chromosomal abnormalities in two patients with

concurrent CLL and MM using interphase fluorescence in situ

hybridization (FISH) with a panel of region-specific DNA probes. In

patient 1, the clonal plasma cells harbored IgH translocations

(14q32); however, FISH with probes for the four most frequent IgH

partner genes in MM (CCND1, FGFR3, MAF, and MYC) did not detect

translocations involving any of them.

The CLL cells were characterized by deletions of 13q14, 11q23, and

17p13, as well as trisomy 12, none of which were found in the MM

cells. In patient 2, deletions of 13q14 and 17p13 were detected in

CLL cells, but no cytogenetic abnormalities were found in the MM

cells. Both patients had relapsed MM following chemotherapy and had

autologous stem-cell transplant, whereas their CLL has been stable

and not requiring treatment.

Our results show that the cytogenetic profiles differ between CLL and

MM within the same patients, and provide evidence for two distinct

malignant clones in both patients.

PMID: 14697640 [PubMed - as supplied by publisher]