Recurrent cytogenetic findings in subsets of patients with chronic lymphocytic leukemia expressing IgG-switched stereotyped immunoglobulins

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Haematologica, Vol 93, Issue 3, 473-474 doi:10.3324/haematol.11872

Recurrent cytogenetic findings in subsets of patients with chronic lymphocytic

leukemia expressing IgG-switched stereotyped immunoglobulins

Anastasia Athanasiadou, Kostas Stamatopoulos, Gaitatzi, Niki Stavroyianni,

Athanasios Fassas, Achilles Anagnostopoulos

Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki,

Greece

Correspondence: Kostas Stamatopoulos, M.D., Hematology Department and HCT Unit,

G. Papanicolaou Hospital, 57010 Thessaloniki, Greece. Phone: international

+30.2310350538., Fax: international +30.2310350579. E-mail:

kostas.stamatopoulos@...

We report a remarkable association of recurrent (stereotyped) cytogenetic

aberrations with two subsets of chronic lymphocytic leukemia (CLL) cases

expressing IgG-switched, stereotyped B-cell receptors (BCRs). Comparison with

cases with heterogeneous BCRs showed that these recurrent cytogenetic

aberrations were subset-biased. These findings further support a role for

antigen in CLL development.