Second malignancies in B-cell chronic lymphocytic leukaemia: possible association with human papilloma virus

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Second malignancies in B-cell chronic lymphocytic leukaemia: possible

association with human papilloma virus.

JM Flynn, L Andritsos, D Lucas, and JC Byrd

Br J Haematol, March 8, 2010; .

Division of Haematology and Oncology, The Ohio State University Medical Center,

Columbus, OH, USA.

Summary Second primary malignancies have long been associated with chronic

lymphocytic leukaemia (CLL). We assessed secondary tumour samples from CLL and

control patients for the presence of human papilloma virus (HPV). 132 CLL

patients with 44 second malignancies were compared to a matched

randomly-identified control population of 264 non-CLL patients with 54 solid

malignancies. Polymerase chain reaction was performed with the highly conserved

MY09/MY11 HPV primer. None of control samples were HPV-positive, while 53% of

samples from the CLL group were positive. This report describes preliminary

evidence for the presence of HPV in secondary malignancies, in patients with

CLL.

PMID: 20230400

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