HLA-G expression in hematologic malignancies.

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BlankHLA-G expression in hematologic malignancies.

WH Yan

Expert Rev Hematol, February 1, 2010; 3(1): 67-80.

Medical Research Center, Taizhou Hospital of Zhejiang Province, Wenzhou Medical

College, Linhai, Zhejiang, People's Republic of China. yanwhcom@... .

HLA-G is a nonclassic MHC class I molecule that functions as an immunomodulatory

molecule;which has a direct inhibitory effect on immune responses and induces

the generation of suppressor or regulatory cells. The relevance of HLA-G in

various pathologic conditions, such as transplantation, autoimmunity and

infectious and malignant diseases, has been extensively investigated. In the

context of hematologic malignancies, such as acute myeloid leukemia, chronic

lymphocytic leukemia and lymphoma, the expression and clinical significance of

HLA-G was discussed; however, interpretation remains controversial. In this

review, we summarize HLA-G expression in hematologic malignancies and emphasize

the clinical relevance of this expression to disease progression. The possible

mechanism involved in HLA-G expression regulation is also highlighted.

PMID: 21082935