Guest guest Posted October 6, 2006 Report Share Posted October 6, 2006 BlankDetection of risk-identifying chromosomal abnormalities and genomic profiling by multiplex ligation-dependent probe amplification in chronic lymphocytic leukemia. A Buijs, PJ Krijtenburg, and E Meijer Haematologica, October 1, 2006; 91(10): 1434-5. Division of Biomedical Genetics, Department of Medical Genetics, University Medical Center Utrecht, PO BOX 85090, 3508 AB Utrecht, The Netherlands. a.buijs@.... We performed genomic profiling using multiplex ligation-dependent probe amplification (MLPA) in 54 cases with suspected or advanced chronic lymphocytic leukemia (CLL). MLPA detected abnormalities when the percentage of mutated cells was greater than ~35%. Loss of 9p21 CDNK2A/B was revealed. MLPA is an economically attractive, powerful tool in trial-based, centralized risk-assessment for CLL. PMID: 17018399 Quote Link to comment Share on other sites More sharing options...
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