Aberrant somatic hypermutation in transformation of follicular lymphoma and chronic lymphocytic leukemia to diffuse large B-cell lymphoma.

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BlankAberrant somatic hypermutation in transformation of follicular lymphoma and

chronic lymphocytic leukemia to diffuse large B-cell lymphoma.

D Rossi, E Berra, M Cerri, C Deambrogi, C Barbieri, S Franceschetti, M Lunghi, A

Conconi, M li, A Matolcsy, L Pasqualucci, D Capello, and G Gaidano

Haematologica, October 1, 2006; 91(10): 1405-9.

Division of Hematology, Department of Clinical and Experimental Medicine &

IRCAD, Amedeo Avogadro University of Eastern Piedmont, Via Solaroli 17, 28100

Novara, Italy. rossidav@....

The molecular mechanisms involved in histologic transformation of

follicular lymphoma (FL) and B-chronic lymphocytic leukemia (B-CLL) to diffuse

large B-cell lymphoma (DLBCL) are heterogeneous and largely unknown. Here we

explored whether aberrant somatic hypermutation, leading to the acquisition of

new mutations in PIM-1, PAX-5, RhoH/TTF and c-MYC genes, is involved in

transformation from FL or B-CLL to DLBCL. Eighteen sequential pairs of FL/DLBCL

(n=9) and B-CLL/DLBCL (n=9) were investigated. Our findings demonstrate that

acquisition of novel mutations due to aberrant somatic hypermutation was

associated with DLBCL transformation in 5/9 (55.5%) cases of FL and 2/9 (22.2%)

cases of B-CLL.

PMID: 17018394