Increasing Adhesion of Donor's Cells in BMT May Boost Engraftment

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Am J Hematol. 2003 Nov;74(3):216-7.

Significance of increasing adhesion of cord blood hematopoietic cells

and a new method: platelet microparticles.

Liu B, Liao C, Chen J, Gu S, Wu S, Xu Z.

Guangzhou Cord Blood Bank, Guangzhou Mothers and Children Hospital,

Guangzhou, China.

Hematopoietic recovery after transplantation with cord blood (CB) is

slower than with bone marrow (BM) and mobilized peripheral blood.

Adhesion molecules (AMs) on hematopoietic cells are involved in

hematopoietic cells' homing. It may be possible to enhance CB CD34+

cells engraftment by increasing their expressions of AM.

Twenty-three patients with childhood acute leukemia treated with

unrelated CBT were studied. It was found that the time to neutrophil

recovery correlated with CXCR4 and the time to platelet recovery

correlated with both CD62L and CXCR4.

Platelet microparticles (PMPs) carry some AMs such as aIIb b (CD41),

P-selectin (CD62P), and CXCR4, CD34+ cells express platelet-binding

antigens (CD162 and CD11b). It was found that AMs were increased

dramatically on CD34+ cells surface in the presence of PMPs, and

CD34+ cells covered with PMPs adhered better to human umbilical vein

endothelial cells and fibronectin.

These findings suggested that PMPs could increase adhesion of donor's

cells to host BM in CBT. Copyright 2003 Wiley-Liss, Inc.

PMID: 14587057 [PubMed - indexed for MEDLINE]