Association of squamous cell carcinoma of the larynx and chronic lymphoid leukemia

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Blank Association of squamous cell carcinoma of the larynx and chronic lymphoid

leukemia.

B Hammami, M Mnejja, I Achour, A Chakroun, A Khabir, A Chakroun, T Boudawara, I

Charfeddine, and A Ghorbel

Eur Ann Otorhinolaryngol Head Neck Dis, September 1, 2010; 127(4): 153-5.

Service d'ORL et chirurgie cervicofaciale, CHU Habib Bourguiba, 3029 Sfax,

Tunisia.

INTRODUCTION: The association of squamous cell carcinoma of the larynx and

chronic lymphocytic leukemia (CLL) is exceptional. We report an observation of

this association and present the therapeutic problems as well as the effects on

prognosis. OBSERVATION: Direct laryngoscopy showed a tumor of the right

hemilarynx, with the biopsy concluding in moderately differentiated keratinizing

squamous cell carcinoma. The patient had a total laryngectomy, with bilateral

lymph node evidement. The anatomopathological examination of the operative

specimen demonstrated infiltration of the larynx and squamous cell carcinoma

adenopathies and CLL. It was decided to monitor the chronic lymphoid leukemia,

classified as Binet stage?B. The synchronous or metachronous onset of a second

cancer in a patient with CLL is more frequent than in the general population.

The synchronous association of squamous cell carcinoma of the larynx and CLL has

been described only rarely. The therapeutic strategy should focus first on the

cancer with the shortest survival rate. The prognosis is more negative in an

association of cervicofacial squamous cell carcinoma and leukemia than in a

single cervicofacial cancer.

PMID: 20851364