The CFIDS Association of America: XMRV Study published today in Journal of Virol

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Today in the Journal of Virology, researchers from the University of Utah, Fatigue Consultation Clinic and ARUP Laboratories published a study titled, "Absence of XMRV and other MLV-related viruses in patients with chronic fatigue

syndrome." The paper reports results using multiple methods of testing for these retroviruses in 100 patients and 200 healthy controls drawn from the same geographic region (Salt Lake City). Also included in the study were 25 subjects identified by the Whittemore Institute (WPI), 14 of whom had tested positive for XMRV on multiple occasions by the WPI lab.

The authors write, "We did not find XMRV or related MLVs, either as viral sequences or infectious virus, nor did we find antibodies to these viruses in any of the patient samples, including those from the original [science, Oct. 2009] study...Our findings do not support an association between CFS and MLV-related viruses including XMRV." The final sentence of the lengthy and detailed paper reads, "It is also vital to state that there is still a wealth of prior data to encourage further research into the involvement of other infectious agents in CFS, and these efforts must continue."

Figure showing the collection, processing and analysis of blood samples from CFS patients and healthy volunteers.

You can expect to hear more from the CFIDS Association and media outlets about this important study, the most comprehensive of the studies following up on the original report from WPI, Cleveland Clinic and the National Cancer Institute.

In the meantime, here are some resources that describe this study and its thorough attempt to replicate many of aspects of the initial study:

Journal of Virology (abstract) Journal of Virology (PDF download) Press release from University of Utah Virology Blog post by Racaniello, PhD, Columbia University (note comments and Dr. Racaniello's replies to questions)

Reference: Clifford H. Shin, Lucinda Bateman, Schlaberg, M. Bunker, J. Leonard, W. Hughen, Alan R. Light, Kathleen C. Light, Ila R. Singh1 (2011). Absence of XMRV and other MLV-related viruses in patients with Chronic Fatigue Syndrome. Journal of Virology : 10.1128/JVI.00693-11

For more information about XMRV, please visit our XMRV overview and resources pages.

Our Mission:

For CFS to be widely understood, diagnosable,

curable and preventable. Our Strategy:

To stimulate research aimed at the early detection, objective diagnosis and effective treatment of CFS through expanded public, private and commercial investment. Our Core Values:

To lead with integrity, innovation and purpose.

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The CFIDS Association of America | PO Box 220398 | Charlotte | NC | 28222-0398