Lymphopenic effect

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Has this " lymphopenic effect " explanations of some sort?

Thanks

carla

Ann Pharmacother. 1995 Sep;29(9):865-7. Related Articles, Links

Lymphopenic effect of carbamazepine in a patient with chronic

lymphocytic leukemia.

Silverman DA, Chapron DJ.

Hebrew Home and Hospital, West Hartford, CT, USA.

OBJECTIVE: To report a dramatic and reproducible suppressive effect of

carbamazepine on circulating lymphocytes in an elderly woman with chronic

lymphocytic leukemia. CASE SUMMARY: An elderly woman taking phenytoin for a

stroke-associated seizure disorder had lymphocyte count of 28,800 x 10(6)

cells/L. Speculating an unusual lymphadenopathic effect of the phenytoin

therapy, carbamazepine therapy was substituted. After 15 weeks of carbamazepine

treatment, the lymphocyte count declined to 3200 x 10(6) cells/L. Because of

severe diarrhea, carbamazepine therapy was stopped and phenytoin therapy was

reinstituted. At the end of 4 months of phenytoin treatment, the lymphocyte

count had increased to 23,200 x 10(6) cells/L. Phenytoin therapy was

discontinued and carbamazepine therapy was begun. The lymphocyte count decreased

to 10,700 x 10(6) cells/L. Severe diarrhea recurred and phenytoin treatment was

reinstituted. Over 12 days the lymphocyte count increased to 28,900 x 10(6)

cells/L. Phenytoin therapy was stopped and valproic acid therapy was started.

The lymphocyte count continued to increase during valproic acid therapy,

reaching a peak of 114,300 x 10(6) cells/L. DISCUSSION: In this patient with

chronic lymphocytic leukemia, carbamazepine therapy had a significant and

reproducible lymphopenic effect that was readily reversible upon discontinuation

of the drug. Unfortunately, this effect was associated with severe diarrhea,

preventing further attempts at exploiting this potentially beneficial action.

CONCLUSIONS: Carbamazepine had a reproducible suppressive effect on lymphocyte

counts in an elderly patient with chronic lymphocytic leukemia. This unique

observation raises the possibility that carbamazepine therapy may have a useful

effect in patients with chronic lymphocytic leukemia.

Publication Types:

a.. Case Reports

PMID: 8547733 [PubMed - indexed for MEDLINE]

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