[CO-CURE] NOT, RES: 1st Intl. Workshop on XMRV scientific program

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[CO-CURE] NOT, RES: 1st Intl. Workshop on XMRV scientific program

1st Intl. Workshop on XMRV scientific program

http://www.virology-education.com/html/virology/document_download.cfm?doc=7B8A4161-945A-B176-59E650D0423712C5.PDF & doc_name=Program_XMRV_final

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1st International Workshop on XMRV

7-8 September 2010, Bethesda, MD, USA

Program

Tuesday 7 September

1.00PM Opening workshop S. LeGrice

Session 1:

Setting the Scene ----- Virology

Chairs: Dr Stoye & Dr Nobert Bannert

1.15PM Invited lecture: Basic Virology - J. Coffin

1.45PM Invited lecture: Viral Integration - S. Chow

2.15PM Invited lecture: Crystal structure of XMRV protease - A. Wlodawer

2.30PM Screening mouse genomes for XMRV-like elements - O. Cingoz O_01

2.45PM A novel gene product of the prostate cancer associated retrovirus, XMRV - R. Molinaro O_02

3.00PM Discussion

3.15PM Coffee break & poster viewing session I

Session 2:

Setting the Scene ----- Host responses

Chairs: Dr Coffin & Dr Walid Heneine

4.00PM Invited lecture: Animal Models - R. Silverman

4.30PM Invited lecture: Vaccine development - E. Sparger

5.00PM Invited lecture: Host restriction factors and interferon - K. Bishop

5.30PM Wild-derived mouse (Mus pahari) as a small animal model for XMRV infection - Y. Ikeda O_03

5.45PM XMRV induces a chronic replicative infection in rhesus macaques tissues but not in blood. - F. Villinger O_04

6.00PM Evolution and species distribution of functional and sequence variants of the mammalian XPR1 receptor for XMRV and mouse xenotropic gammaretroviruses - C. Kozak O_05

6.15PM Discussion

6.30PM End of Plenary session

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Wednesday 8 September

Session 3:

Prostate Cancer

Chairs: Dr Silverman & Dr Dahut

08.30AM Invited lecture on Prostate Cancer - E. Klein

09.00AM Invited lecture: Pathogenesis - I. Singh

09.30AM Variant XMRVs in clinical prostate cancer - J. Petros O_06

09.45AM Failure to detect XMRV in prostate cancer and benign prostatic tissues - K. Sfanos O_07

10.00AM XMRV prevalence in prostate cancer tissue and the role of the prostate compartment in XMRV infection - N. Fischer O_08

10.15AM XMRV infection of prostate cancer patients from the Southern United States and analysis of possible correlates of infection - B.

son O_09

10.30AM Discussion

10.45AM Coffee Break + poster viewing session II

Session 4:

Chronic Fatigue Syndrome

Chairs: Dr Coffin & Dr Judy Mikovits

11.15AM Invited lecture on Chronic fatigue syndrome - F. Ruscetti

11.45AM Prevalence of XMRV in CFS patients and healthy controls - B. Huber O_10

12.00PM XMRV in Chronic Fatigue Syndrome: A Pilot Study - M. Hanson O_11

12.15PM Detection of MLV-related virus gene sequences in blood of patients with chronic fatigue syndrome and healthy blood donors - S.

Lo O_12

12.30PM Detection of infectious XMRV in the peripheral blood of chronic fatigue syndrome patients in the United Kingdom - J. Mikovits

O_13

12.45PM Discussion

1.00PM Lunch

Session 5:

Assay development

Chairs: Dr Stuart LeGrice & Dr Jerry Holmberg

2.00PM Invited lecture: Assay development/ epidemiology + blood supply

- B. Switzer

2.30PM Development and optimization of a multiplex serological assay to detect XMRV antibodies - R. Bagni O_14

2.45PM Development of a GFP-indicator cell line for the detection of XMRV - K. Lee O_15

3.00PM Development of XMRV immunoassays useful for epidemiologic studies - X. Qiu O_16

3.15PM Validation of XMRV single-copy assays (X-SCA) to detect xenotropic MLV-related virus in human blood products - M. Kearney O_17

3.30PM Discussion

3.45PM Coffee break + poster viewing session III

Session 6:

Epidemiology and Screening

Chairs: Dr Boucher & Dr Rika Furuta

4.15PM No evidence for XMRV in CFS and MS patients in Germany despite the ability of the virus to infect human blood cells in vitro. - N.

Bannert O_18

4.30PM Search for XMRV in Swedish patients with myalgic encephalitis/chronic fatigue syndrome (ME/CFS) and prostate cancer; methods and results. - J. Blomberg O_19

4.45PM Multi-laboratory evaluations of XMRV nucleic acid detection assays - G. O_20

5.00PM Discussion

5.15PM Discussion on the Findings

Moderators: Dr Stoye and Dr Boucher

5.00PM End of Plenary session

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