7q Interstitial Deletions Not Uncommon in CLL

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Beijing Da Xue Xue Bao. 2006 Feb 18;38(1):57-61. Links

The frequency of chromosome 7q interstitial deletions associated with

B-cell lymphoproliferative disorders is substantially high among

hematological malignancies.

Lu G, Zhang J, Pauper K.

Department of Pathology and Genetics, USLabs/LabCorp, Irvine,

California 91612, USA.

OBJECTIVE: To study the frequency of interstitial 7q deletions in B-

cell lymphoproliferative disorders (B-LPDs).

METHODS: Cases were collected from the clinical laboratory diagnosis

database at USLabs/LabCorp over the past two years (2002 to 2004).

Cases that showed deletions in the long arm of chromosome 7 were then

reviewed. Interstitial deletions in the long arm of chromosome 7 were

further investigated according to the indications for clinical

laboratory studies and flow cytometry findings. The final clinical

diagnosis for each case was obtained from the referring physician.

RESULTS: A total of 19 483 cases were included in this series. Eighty-

five cases were observed to have either terminal or interstitial

deletion in the long arm of chromosome 7. Of the 85 cases, 46 had

interstitial deletions accounting for 54.1% of the 7q deletions

combined. B-LPDs were found in 10 of the 46 cases, accounting for

21.7%. The B-LPDs associated with 7q interstitial deletions were

diverse, including B-cell chronic lymphocytic leukemia (B-CLL) in

five cases. The deleted region in the long arm of chromosome 7 in the

10 cases associated with BjLPDs was solely confined to the 7q22-q32

region.

CONCLUSION: (1) The frequency of 7q interstitial deletions associated

with B-LPDs is substantially high; (2) 7q interstitial deletions are

not uncommon in B-CLL.

PMID: 16415968 [PubMed - in process]