Challenging Cancer: A Stressful Lifestyle Reduces Tumor Growth in Mice

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Challenging Cancer: A Stressful Lifestyle Reduces Tumor Growth in Mice

Mice raised in a challenging environment had more robust immune responses and hormonal changes, factors that may help protect against cancer

Stress is often linked to heart disease and other ailments, but a new study suggests that the strains of living in crowded and challenging physical environments might mitigate against cancer. Scientists found that simply placing mice afflicted with cancer in a more complex living environment resulted in a remarkable reduction in tumor growth.

While eating a healthy diet and reducing exposure to carcinogens are certainly important ways to reduce cancer risk, the results show that other components of the environment like an individual's surroundings, social interaction and mental state may also have profound impacts on cancer.

To examine how living conditions might affect cancer development, During of The Ohio State University Comprehensive Cancer Center and colleagues raised mice in either standard laboratory housing (five mice per cage) or in an enriched environment with more room, a greater number of mice (18 to 20 animals), and more challenges and activities (running wheels, tunnels, toys, mazes and nesting material). Mice were then injected with tumor cells, which led to malignancies in all of the control animals within 15 days. By contrast, the rate of tumor formation in animals living in the enriched environment was significantly delayed, and 15 percent had not developed tumors after nearly three weeks; when tumors were visible, they were 43 percent smaller than the lesions on control animals.

"Up front, we didn't really know whether this would be good or bad for cancer," says During, professor of molecular virology, immunology and medical genetics. "We were amazed that the effect was very pronounced," he adds. The study was published online July 8 in Cell .

The cancer resistance was not simply due to increased physical activity, however, because animals that only exercised more did not experience the same benefits. During says he suspects that the key may lie in the more diverse social encounters experienced by the mice in the enhanced environment.

"These [enriched] environments are somewhat stressful for the animals. They're not in a happy place," During says. "It's a more wild, challenging environment."

Consistent with this, the animals in the augmented setting had a slightly elevated stress hormone level as well as stronger immune systems. During noted that the most consistent and dramatic finding, however, was a nearly 90 percent drop in leptin, a hormone produced by fat that helps regulate metabolism. In humans elevated leptin levels are associated with a greater risk of some cancers, including melanoma, breast and prostate malignancies.

The scientists then traced the leptin decline to a pathway that originates in the brain's hypothalamus. They discovered that animals living in the enriched environment had higher levels of a protein called brain-derived neurotrophic factor (BDNF). To determine the role of BDNF in tumor resistance, the scientists engineered an increase in BDNF in the control mice and found that the leptin levels in the animals decreased, their immune systems were boosted, and their tumors shrank. Conversely, eliminating BDNF in the more stimulated mice blocked their lifestyle's tumor-protective effects. These experiments confirmed that the environment-induced increase of BDNF in the brain and consequent decline in leptin were causatively involved in the observed beneficial effects.

http://www.scientificamerican.com/article.cfm?id=mental-and-social-stimulation-reduce-cancer-growth-in-mice & sc=DD_20100708