The Black Death: the Plague

[Guest guest]

Esoterica Medica

Now it's more of a fluke than a plague

Few people die of the disease anymore, but it once wreaked havoc and

was even used as a bioweapon. December 10, 2007

Each year in the western U.S., a handful of people come down with the

plague, catching the ancient disease from animals (often rodents) that

harbor the bacteria. A National Park Service employee recently died of

the disease, and an Arizona woman became infected but survived.

Today, such cases get little press. But in ancient times, the plague

evoked intense fear, panic and chaos -- for good reason. Throughout

history, the disease has exacted a devastating toll on cities,

countries and even entire continents.

In the 6th century, plague swept across Asia, Africa and Europe,

hitting Constantinople -- then seat of the Roman Empire --

particularly hard. Over the course of the four-month epidemic in the

city now known as Istanbul, 5,000 to 10,000 people a day died. When

the city ran out of room for burials, the dead were piled on boats and

sent out to sea. Even the emperor, ian, was infected. But

although he recovered, his reign did not: The plague divided it neatly

into a period of glory and a subsequent one of decline.

The most notorious plague epidemic struck Europe in the Middle Ages.

Called the Black Death, the disease -- which caused painful, gruesome

deaths and sometimes blackened the skin in the process -- threw the

continent into turmoil. It killed one-third to half of the population,

effecting lasting social and economic changes that, according to some

historians, led the feudal system to crumble.

The plague resurfaced again in the ports of Hong Kong in the late 19th

century, causing an epidemic that killed 100,000 but that seemed minor

compared with the Black Death. In 1894, French scientist andre

Yersin identified a type of bacteria in the swollen lymph glands of

plague-infected patients, and then isolated the same bacteria from

infected mice. (The plague-causing bacteria, Yersinia pestis, is named

for him.) Four years later, his compatriot -Louis Simond showed

that fleas spread the bacteria from sick rats to healthy rats -- and

to people.

But news of plague's relationship to fleas and rats didn't spread as

fast as the disease itself.

In 1900, plague reached the United States for the first time,

surfacing in San Francisco's Chinatown. As the disease spread,

newspaper editorials called for Chinatown's destruction. Health

officials cordoned off the entire neighborhood, banned the city's

Asian population from traveling, and attempted to forcibly vaccinate

Chinese San Franciscans -- actions that ultimately led to a

class-action lawsuit settled in favor of the city's Asian population.

The plague lingered in San Francisco until 1904, then disappeared for

three years. But in 1907, the disease surfaced again. The 1906

earthquake had turned much of the city into a refugee camp, creating

conditions that allowed the local rat population to explode.

Crowds of volunteers responded by spreading arsenic-tainted cheese on

scraps of bread and placing the deadly bait around the city. Millions

of rats died, and the epidemic subsided -- but not before plague took

up permanent residence in the squirrels and mice in the hills to the

east of the city. (Many rodents are unharmed by the bacteria; urban

black rats, like humans, die of the infection.)

Plague returned to California one last time in 1924, this time causing

an outbreak in Los Angeles. Health officials cordoned off Mexican

immigrant neighborhoods, where the disease was thought to reside,

killing cats, dogs and thousands of rats with poison, but also with

guns and gas.

The California plagues killed relatively few: slightly more than 200

in San Francisco and 30 in Los Angeles. But like all epidemics of

plague, they sparked social unrest and economic and political turmoil.

Some U.S. states banned California visitors, produce and other goods.

Central American countries refused to let California ships into

harbors and accused the state of shipping plague-infested rats in

their exports of vegetables.

That ability to cause panic has long made plague a weapon of war. In

the medieval era, plague-ridden bodies were tossed over city walls by

warring forces. During World War II, the Japanese dropped

plague-infested fleas over China. The former Soviet Union stockpiled

20 tons of weapons-grade plague during the Cold War. The U.S. tried

the same but couldn't get the germs to stay virulent.

That's why some scientists say that plague won't ever make it as a

weapon of mass destruction: It's too unstable and not nearly

infectious enough. In fact, just one form of plague is contagious.

Fleas transmit bubonic plague from rodents to humans; when the

infection reaches the lungs, it causes pneumonic plague, which then

spreads from person to person. But since the advent of antibiotics --

and the disappearance of rats and fleas from most homes -- that rarely

happens in the U.S.

Despite the country's population of plague-carrying rodents and the

handful of human cases that occur each year, plague hasn't spread from

person to person in the U.S. since the Los Angeles outbreak of 1924.

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