Noninvasive staging of liver fibrosis

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Noninvasive staging of liver fibrosis

86-105-908-0039World Journal of Gastroenterology

Elastography: A useful method in depicting liver hardness

Palpation continues to be of great value in modern medicine, both practiced by doctors and as a technique for self-examination. However, palpation is limited to a few accessible organs, and the interpretation of the information sensed by the fingers is highly subjective.Recently, elastography has emerged as an option in several commercial ultrasound systems, and is starting to prove clinically valuable in many areas. Elasticity measurements have been reported to be useful for the diagnosis and differentiation of many tumors, which are usually harder than normal surrounding tissues. Recently, transabdominal real-time elastography was proposed as a new method for noninvasive staging of liver fibrosis.

A research article to be published on April 14, 2010 in the World Journal of Gastroenterology addresses this question. The elastography study was lead by Professor Săftoiu and Dr. Dan Ionuţ Gheonea at the Research Center of Gastroenterology and Hepatology, University of Medicine and Pharmacy, Craiova, Romania. The aim of the study was to assess whether computer-enhanced dynamic analysis of real-time elastography movies was better able to characterize and differentiate between different degrees of liver fibrosis.

The results of the study concluded that real-time elastography is certainly a very useful method in depicting liver hardness, although it has been tested incompletely in large multicenter studies, and should be compared with other noninvasive methods (e.g. blood markers, transient elastography).

The authors suggested also an improvement in the examination methodology, which should take into account previous observations made by different authors (e.g. better transducers, improved elastography software) to establish real-time elastography as a new revolutionary method that can replace liver biopsy for assessment of different stages of fibrosis in patients with chronic hepatitis.

###Reference: Gheonea DI, Săftoiu A, Ciurea T, Gorunescu F, Iordache S, Popescu GL, Belciug S, Gorunescu M, Săndulescu L. Real-time sono-elastography in the diagnosis of diffuse liver diseases.

World J Gastroenterol 2010; 16(14): 1720-1726http://www.wjgnet.com/1007-9327/full/v16/i14/1720.htmCorrespondence to: Dan Ionuţ Gheonea, MD, PhD, MSc, Research Center of Gastroenterology and Hepatology, University of Medicine and Pharmacy Craiova, 1 Mai, 66, Craiova 200639, Romania. digheonea@...

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About World Journal of GastroenterologyWorld Journal of Gastroenterology (WJG), a leading international journal in gastroenterology and hepatology, has established a reputation for publishing first class research on esophageal cancer, gastric cancer, liver cancer, viral hepatitis, colorectal cancer, and H. pylori infection and provides a forum for both clinicians and scientists. WJG has been indexed and abstracted in Current Contents/Clinical Medicine, Science Citation Index Expanded (also known as SciSearch) and Journal Citation Reports/Science Edition, Index Medicus, MEDLINE and PubMed, Chemical Abstracts, EMBASE/Excerpta Medica, Abstracts Journals, Nature Clinical Practice Gastroenterology and Hepatology, CAB Abstracts and Global Health. ISI JCR 2008 IF: 2.081. WJG is a weekly journal published by WJG Press. The publication dates are the 7th, 14th, 21st, and 28th day of every month. WJG is supported by The National Natural

Science Foundation of China, No. 30224801 and No. 30424812, and was founded with the name of China National Journal of New Gastroenterology on October 1, 1995, and renamed WJG on January 25, 1998.About The WJG PressThe WJG Press mainly publishes World Journal of Gastroenterology

http://www.eurekalert.org/pub_releases/2010-04/wjog-eau041210.php

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