The causes of CMT - from Germang

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Abstract from Cell Mol Life Sci. 2003 Dec;60(12):2547-60.

The causes of Charcot-Marie-Tooth disease.

Young P, Suter U.

Department of Neurology, University of Munster, Munster, Germany.

Charcot-Marie-Tooth (CMT) disease serves as the summary term for the

most frequent forms of inherited peripheral neuropathies that affect

motor and sensory nerves. In the last 12 years, 14 genes have been

identified that cause different CMT subforms. The genes found initially

are predominantly responsible for demyelinating and dysmyelinating

neuropathies. Genes affected in axonal and rare forms of CMT have only

recently been identified. In this review, we will focus on the currently

known genes that are associated with CMT syndromes with regards to their

genetics and function.