(SVR) rates in Asians with chronic hepatitis C (CHC) exceed those of other ethnic groups/peginterferon

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(SVR) rates in Asians with chronic hepatitis C (CHC) exceed those of other ethnic groups/peginterferon

Reported sustained virological response (SVR) rates in Asians with chronic hepatitis C (CHC) exceed those of other ethnic groups, but differences in body weight across races potentially confound this observed superior response. ;

Our aim was to determine whether Asian race independently predicts SVR within a multicultural clinic setting.

..MethodsPatients with genotype 1, 2 and 3 CHC prescribed peginterferon and weight-based ribavirin were included in this retrospective study. Logistic regression was performed to identify factors associated with SVR.

/.ResultsThree-hundred ninety-two patients (BMI 26.9 ± 5.0 kg/m2, genotype 1 66%, viral load 5.9 ± 0.66 log10 IU/ml, advanced fibrosis 53%) were included in this study. ,

Caucasians comprised 81%, South Asians 9% and Asians (Non-South) 10%. ,

SVR was achieved by 54% overall, but was highest amongst Asians (Non-South) (79%) compared with South Asians (56%, P = 0.04) and Caucasians (50%, P less then 0.001) despite a predominance of genotype 3 infection amongst the South Asians.

Asians (Non-South) had the highest SVR rate even amongst those infected with genotype 1 (75%) and those with advanced fibrosis (77%). Independent of viral genotype, Asian (Non-South) race was a strong predictor of SVR (OR 5.10 vs. Caucasians, 95% CI 1.72–17.71, OR 7.84 vs. South Asians, 95% CI 1.62–37.84), as were treatment naïve status (OR 3.85, 95% CI 1.76–8.89), non-diabetic status (OR 3.70, 95% CI 1.30–11.11), non-obesity (OR 2.13, 95% CI 1.06–4.35), peginterferon α2a (2.08 vs. α2b, 95% CI 1.16–3.85), steatosis less the 10% .

ConclusionAsian (Non-South) race is a strong independent predictor of SVR.Keywords Asian - Sustained virological response - Body mass index - Weight - Obesity - Diabetes - Chronic hepatitis C

http://www.springerlink.com/content/c1k308551kr22545/

http://Hepatitis Cnewdrugs.blogspot.com/2010/08/svr-rates-in-asians-with-chronic.html