muscle biopsy findings

[Guest guest]

RE: the muscle biopsy issue - this is over a year old, but was of

interest to me and might be to others. And ka, I had both

muscle and nerve biopsy in 1966 in two different sections of my

left leg. It did not hurt because I was given a local anesthetic.

At that time it was necessary to stay overnight in the hospital.

I just felt some minor pain, like a muscle strain as the healing

process continued. It was no big deal for me. The biopsies were

done not only to exclude the possibility of other neuromuscular

disorders, but also to reconfirm the CMT issue. In 1966 the DNA

blood test did not exist. ~ Gretchen

From Exerc Sport Sci Rev. 2002 Jan;30(1):4-7. Related Articles, Links

Muscle biopsy abnormalities differ between Charcot-Marie-Tooth type 1

and 2: reflect different pathophysiology?

Borg K, son-Gripenstedt U.

Department of Rehabilitation Medicine, Huddinge University Hospital,

Stockholm, Sweden.

Muscle biopsy specimens have shown neuropathic findings in

Charcot-Marie-Tooth (CMT) disease Type 1 (demyelinating form) and

myopathic findings in CMT 2 (axonal form). Neurophysiological studies

showed an active denervation-reinnervation process in CMT 1, whereas the

CMT2 patients had a low reinnervation capacity and, thus, compensated

for the loss of motor units by increasing the contractile tissue.