neurofilaments and CMT research

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Abstract from Bioessays 2003 Apr;25(4):346-55

Neurofilaments and neurological disease. (mentions CMT)

Al-Chalabi A, CC.

Departments of Neuroscience and Neurology, King's College London, UK.

Neurofilaments are one of the major components of the neuronal

cytoskeleton and are responsible for maintaining the calibre of axons.

They are modified by post-translational changes that are regulated in

complex fashions including by the interaction with neighbouring glial

cells. Neurofilament accumulations are seen in several neurological

diseases and neurofilament mutations have now been associated with

Charcot-Marie-Tooth disease, Parkinson's disease and amyotrophic lateral

sclerosis. In this review, we discuss the structure, normal function and

molecular pathology of neurofilaments.