] re Interesting article- very interesting

[Guest guest]

Oops sent this to the wrong group earlier!

[thyroid treatment_Chat] re Interesting article- very interesting

http://www.aacc.org/AACC/events/expert_access/2006/TSHRange/Presentation

Re the article link that was posted here are some quotes:

The reason is that TSH is so exquisitely sensitive to free T4 status is that

individuals have a genetically determined free T4 setpoint, as illustrated by the

study of Andersen in which free T4 was measured each month for a year

period in 16 normal euthyroid individuals.

Although all the values fell within the population reference range, clearly the

free T4 setpoint of some individuals was lower than for others.

and

It is important to recognize the limitations of using population reference

ranges for thyroid tests, all of which have a low index of individuality.

It is important to eliminate the concept of a “normal†range and replace it with

the term “reference†range.

In fact, in an individual a TSH change that exceeds 0.75 mIU/L is biologically

significant.

These specificity differences are an added variable that makes the setting of a

universal upper TSH reference limit impossible.

a Gaussian

distribution would project a TSH upper limit between 2.5 and 3.0 mIU/L and

not 4 to 5 mIU/L, as reported by population studies.

Thereafter, with progression of disease, mild (subclinical) hypothyroidism

(isolated high TSH) develops and subclinical hypothyroidism is known to

progress to overt hypothyroidism (high TSH/low FT4) at a rate of ~5%/year.

We know from the Whickham 20-year follow-up survey that a TSH above ~2

mIU/L is a risk factor for the future development of hypothyroidism,

especially when TPOAb is detected.

Conclusion

Conclusions

Each individual has their own TSH range that spans ~ 0.75 mIU/L.

The population reference range is NOT an individual’s ‘normal range’

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[Guest guest]

Hi ,

I notice that the

proposed ‘top ‘ of the range TSH 10 is not even remotely mentioned.

http://www.aacc.org/AACC/events/expert_access/2006/TSHRange/Presentation

a Gaussian

distribution would

project a TSH upper limit between 2.5 and 3.0 mIU/L and

not 4 to 5 mIU/L, as

reported by population studies.

Conclusions

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account with unlimited storage. Plus, share and store photos and experience

exclusively recorded live music Sessions from your favourite artists. Click Here

for more information.