Better to take Thyroxine late evening

[Guest guest]

http://www.blackwell-synergy.com/doi/full/10.1111/j.1365-2265.2006.02681.x?cookieSet=1

Objective Standard drug information resources recommend that l-thyroxine be taken half an hour before breakfast on an empty stomach, to prevent interference of its intestinal uptake by food or medication. We observed cases in which TSH levels improved markedly after changing the administration time of l-thyroxine to the late evening. We therefore conducted a pilot-study to investigate whether l-thyroxine administration at bedtime improves TSH and thyroid hormones, and whether the circadian rhythm of TSH remains intact.

....l-thyroxine taken at bedtime by patients with primary hypothyroidism is associated with higher thyroid hormone concentrations and lower TSH concentrations compared to the same l-thyroxine dose taken in the morning. At the same time, the circadian TSH rhythm stays intact. Our findings are best explained by a better gastrointestinal uptake of l-thyroxine during the night.

For those of you who have difficulty sleeping at night, Thyroxine at night helps you sleep better it appears.

For those who would like to see a full discussion about this on the American About.com/Thyroid Forum, here is a link http://forums.about.com/n/pfx/forum.aspx?msg=61884.1 & nav=messages & webtag=ab-thyroid#a1

Luv - Sheila

[Guest guest]

I always take my T4 at night. I only use 25mcg though.

Lots of ladies on the Delphi Thyroid Diaries board (people who left

about.com when they changed to the blue format) also take their T4 at

bedtime.

Jen

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> For those of you who have difficulty sleeping at night, Thyroxine at

night helps you sleep better it appears.