Re: T1/3-iodothyronamine

[Guest guest]

Another link to T1. It covers the same info as I mailed before but this

link is from Oregon Health & Science University where the study was

done.

http://www.ohsu.edu/unparchive/2004/051604thyroid.html

V

>

> In case anyone is intersted, here is a couple of sites of T1 & T0.

>

> http://www.eurekalert.org/pub_releases/2004-05/ohs-ncm051404.php

>

> http://webbolt.ecnext.com/coms2/description_29637_Oregon190504_MED

>

>

http://www.allthyroid.com/research/summaries/archive/hormone/04_11_thyro

> nanmines.html

>

> http://www.nature.com/nm/journal/v10/n6/abs/nm1051.html

> V

>

[Guest guest]

These are amazing findings, ! It sounds like we are starting a new era with

thyroid hormones/neurotransmitters! This goes way beyond what we knew about T4

and T3. Again, shows how crucial the specific form is.

I've added the T1 references to the links, here:

iodine/links/How_Iodine_Affects_t_001138666\

832/Thyroid_001138148449/20_Thyroid_Hormones_001149977740/T1_001154376554/

I found a 2006 article by the same authors. I think they are saying they have

now synthesized T1 and various related analogs.

T1 induces hypothermia -- it has the opposite effect of T3 and T4. They are

speculating on all kinds of possible uses for T1, including as a treatment for

hyperthyroid conditions and various heart issues. Since T1 operates so much

faster than traditional hormones, they are thinking of it as a neurotransmitter.

Trace amine-associated receptor agonists: synthesis and evaluation of

thyronamines and related analogues.

Hart ME, Suchland KL, Miyakawa M, Bunzow JR, Grandy DK, Scanlan TS., 2006.

Abstract.

" We have previously shown that several thyronamines, decarboxylated and

deiodinated metabolites of the thyroid hormone, potently activate an orphan G

protein-coupled receptor in vitro (TAAR1) and induced hypothermia in vivo on a

rapid time scale [scanlan, T. S.; Suchland, K. L.; Hart, M. E.; Chiellini, G.;

Huang, Y.; Kruzich, P. J.; Frascarelli, S.; Crossley, D. A.; Bunzow, J. R.;

Ronca-Testoni, S.; Lin, E. T.; Hatton, D.; Zucchi, R.; Grandy, D. K.

3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid

hormone. Nat. Med. 2004, 10 (6), 638-642].

Herein, we report the synthesis of these thyronamines. Additionally, a large

number of thyroamine derivatives were synthesized in an effort to understand the

molecular basis of TAAR1 activation and hypothermia induction. Several

derivatives were found to potently activate both rTAAR1 and mTAAR1 in vitro

(compounds 77, 85, 91, and 92). When administered to mice at a 50 mg/kg dose,

these derivatives all induced significant hypothermia within 60 min and

exhibited a hypothermic induction profile analogous to 3-iodothyronamine (1,

T(1)AM) except 91, which proved to be more efficacious. On the basis of this

result, a dose-dependent profile for 91 was generated and an ED(50) of 30

mumol/kg was calculated. Compound 91 proved to be more potent than T(1)AM for

TAAR1 activation and exhibits increased potency and efficacy for hypothermia

induction. These data further strengthen the pharmacological correlation linking

TAAR1 activation by thyronamines and hypothermia induction in mice. "

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Retrieve & dopt=Abstra\

ctPlus & list_uids=16451074 & query_hl=9 & itool=pubmed_docsum

Zoe

Re: T1/3-iodothyronamine

Another link to T1. It covers the same info as I mailed before but this

link is from Oregon Health & Science University where the study was

done.

http://www.ohsu.edu/unparchive/2004/051604thyroid.html

V