Re: Cod Liver Oil - Pyroluria

[Guest guest]

Wow. My two favourite sujects lately!! I am currently awaiting my

results for pyroluria. I have ALL the symptoms.

Its so sad 'cause cod liver oil are my only reliable sources of

vitamins A and D =(

I would asume the iodine in cod liver oil would be negligible. Am I

right?

Mandy from Oz

>

> (Has anyone else experienced iodine-like symptoms with cod liver

oil?)

> " I have several relatives who do, and people with the disorder

pyroluria (google for description) generally have problems with cod

liver oil, fish oil, kelp, and flax. It's blamed on the n3's, and

it may be to some extent, but I think iodine is responsible because

fish oils bring symptoms on much stronger than flax (which only has

trace amounts of iodine), and kelp which has little n3. " -- Cara

>

> I looked up Pyroluria and found the following: " Pyroluria is a

genetically determined chemical imbalance involving an abnormality

in hemoglobin synthesis. Hemoglobin is the protein that holds iron

in the red blood cell. Individuals with this disorder produce too

much of a byproduct of hemoglobin synthesis called " kryptopyrrole "

(KP) or " hemepyrrole. " Kryptopyrrole has no known function in the

body, and is excreted in urine.

> Kryptopyrrole has binds to pyridoxine (vitamin B6) and zinc and

makes them unavailable for their important roles of co-factors in

enzymes and metabolism. These essential nutrients when bound to

kryptopyrrole are removed from the bloodstream and excreted into the

urine as pyrroles. Arachidonic acid (an omega-6 fatty acid) is also

deficient....

>

> Most individuals show symptoms of zinc and/or B6 deficiencies,

which include poor stress control, nervousness, anxiety, mood

swings, severe inner tension, episodic anger (an explosive temper),

poor short-term memory and depression. Most pyrolurics exhibit at

least two of these problems. These individuals cannot efficiently

create serotonin (a neurotransmitter that reduces anxiety and

depression) since vitamin B6 is an important factor in the last step

of its synthesis....

>

> Pyroluria is detected by chemical analysis of the abnormal pyroles

in urine detectable as a purple (on testing paper) metabolite in

called " the mauve factor. " ...

>

> People with mild-moderate pyroluria usually have a fairly rapid

response to treatment if no other chemical imbalances are present.

People with severe pyroluria usually require several weeks before

progress is seen and improvement may be gradual over 3 - 12

months....

>

> Pyroluria is managed in part by restoring vitamin B6 and

zinc....Other nutrients may assist in pyroluria include niacinamide,

pantothenic acid, manganese, vitamins C and E, omega-6 fatty acids

and cysteine. Food sources and nutritional supplements containing

copper and red/yellow food dyes should be avoided.

>

> Because pyrolurics are stress intolerant, they seem to be

especially vulnerable to cumulative stress over many days.

>

> http://www.drkaslow.com/html/pyroluria.html

>

> Beneficial supplements: Vitamin B6, zinc, manganese, evening

primrose oil

>

> Potentially harmful supplements: Histidine, copper, omega-3 fatty

acids

>

> http://www.nutritional-healing.com.au/content/articles-content.php?

heading=Pyroluria

>

> May have methylation/histamine imbalances.

>

> http://www.nutritional-healing.com.au/content/articles-content.php?

heading=Major%20Mental%20Illness%20Biochemical%20Subtypes

>

> If present, the condition is usually then treated by supplementing

appropriate levels of vitamin B6, zinc, manganese and Evening

Primrose Oil. Antioxidants like vitamin C and vitamin E may also be

supplemented as oxidative stresses are believed to influence the

severity of the condition. In addition, vitamin B3 supplementation

may be considered because the synthesis of niacin (vitamin B3) from

the amino acid tryptophan is dependent upon the availability of

vitamin B6, so a deficiency in B3 could arise from vitamin B6

deficiency.

>

> http://en.wikipedia.org/wiki/Pyroluria

>

> Treatment for Pyroluria: (Must have daily supplement!!!!!)

>

> B6, B6, B6, B6 - (more than 200 mg a day from all combined sources-

ask DR.)

>

> Zinc -seek advice from DR but generally at least 30 mg/day- more

watch copper

>

> Arachadonic Acid (Cod Liver oil is contra-indicated w/o adding

animal fat first)

>

> http://www.defeatautismyesterday.com/Coreissues.htm

>

>

>

> So, this is what I got when I googled " Pyroluria " . Sounds like

you have learned to live with an interesting health challenge. And

what I'm hearing is that you think that the iodine in the cod liver

oil is the critical factor, not the omega 3's. Am I correct in

assuming you have been diagnosed with Pyroluria?

>

> Zoe

>

[Guest guest]

> So, this is what I got when I googled " Pyroluria " . Sounds like

you

> have learned to live with an interesting health challenge. And

what

> I'm hearing is that you think that the iodine in the cod liver oil

> is the critical factor, not the omega 3's. Am I correct in

assuming

> you have been diagnosed with Pyroluria?

>

> Zoe

>

Yes, I tested for pyroluria several years ago. I supplement with Zn

and B6, and don't have the symptoms anymore. I'm sure the n3's

probably do affect pyroluriacs some, but on the old pyroluria list,

we never understood why most of us could eat flax and feel fine, but

not clo or fish oil. Flax actually had more n3's than the high

vitamin clo I was taking, but it never did trigger symptoms.

I asked my biochemistry professor about absorbtion of n3's in flax

oil vs fish oil, and he thought both should be very absorbable. So

that makes me think there is something more in fish-based oils that

cause people these problems.

Pyroluria is not a well-researched condition. Only a few scientists

and practitioners test, treat, or research it so knowledge is

limited. Usually it's caught in people with severe problems - like

autism or schizophrenia. The goal in treating it is usually just to

make the person function normally, not to optimize health, prevent

breast cancer, have more energy, etc. So, much of what is known is

theoretical, annecdotal, and often contradictory.

Cara

[Guest guest]

>

> Its so sad 'cause cod liver oil are my only reliable sources of

> vitamins A and D =(

THat was my problem, too, until I discovered that Carlson's (and a few

other manufacturers) extracts the A and D from cod liver oil and puts

them in gel caps.

> I would asume the iodine in cod liver oil would be negligible. Am I

> right?

I'm guessing negligable for most people, but for sensitive people, it

may be too much.

I ran across an old article about clo, and it seemed as though some

people were attributing the healing properties of clo to iodine, not A

and D. My husband gets lots of energy and stamnia, and fewer joint

aches when he takes his clo (about 1-2 tbsp a day). Once on vacation,

he forgot his clo and took my A and D pills, instead. He did not get

the energy from the pills that he did with clo. This could be due to

cofactors missing from these pills, or something else, but it is

something else to think about.

Cara

[Guest guest]

Hi Cara,

I might have to get a bit more info from you soon - awaiting my test

results =O

About flax oil, many people are unable to convert ALA in flax to EPA

in fish oils. I think it's more the european and mediterranean

people. The enzymes needed for this convertion are hardly active or

not active at all. I stopped my flax oil as soon as heard this.

Also could you tell me what you mean by CLO triggering symptoms.

What symptoms? Thanks

Mandy

>

> > So, this is what I got when I googled " Pyroluria " . Sounds like

> you

> > have learned to live with an interesting health challenge. And

> what

> > I'm hearing is that you think that the iodine in the cod liver

oil

> > is the critical factor, not the omega 3's. Am I correct in

> assuming

> > you have been diagnosed with Pyroluria?

> >

> > Zoe

> >

>

> Yes, I tested for pyroluria several years ago. I supplement with

Zn

> and B6, and don't have the symptoms anymore. I'm sure the n3's

> probably do affect pyroluriacs some, but on the old pyroluria

list,

> we never understood why most of us could eat flax and feel fine,

but

> not clo or fish oil. Flax actually had more n3's than the high

> vitamin clo I was taking, but it never did trigger symptoms.

>

> I asked my biochemistry professor about absorbtion of n3's in flax

> oil vs fish oil, and he thought both should be very absorbable.

So

> that makes me think there is something more in fish-based oils

that

> cause people these problems.

>

> Pyroluria is not a well-researched condition. Only a few

scientists

> and practitioners test, treat, or research it so knowledge is

> limited. Usually it's caught in people with severe problems -

like

> autism or schizophrenia. The goal in treating it is usually just

to

> make the person function normally, not to optimize health, prevent

> breast cancer, have more energy, etc. So, much of what is known

is

> theoretical, annecdotal, and often contradictory.

>

> Cara

>

[Guest guest]

Hi Mandy,

> Also could you tell me what you mean by CLO triggering symptoms.

> What symptoms? Thanks

>

When I first begin taking clo, I feel pretty good - energetic,

optimistic. After a few days to a week (depending on how much I'm

taking), I begin to feel wired. If I keep taking it, the wired

feeling develops into irritability, anxiety, and anger, especially

right around 8-9pm. I get huge welp-like pimples in weird places

like ears, neck, and scalp. My skin feels sore, my gums swell and

lymph nodes swell a little. I sort of feel like a cold is coming

on. All this goes away after I've stopped the clo for about two

days. Good luck with your results!

Cara