Re: Iodine Plasma or Serum Test

[Guest guest]

I don't know if this helps you with anything, but the VRP site

mentions serum levels and how Vitamin C improved the iodine cellular

transport defect:

http://www.vrp.com/art/1797.asp?

c=1160768232750 & k=/det/9139.asp & m=/ & p=no & s=0

" ...Whole body sufficiency for iodine is arbitrarily defined as 90

percent or more of the ingested iodine/iodide load (50 mg) recovered

in the 24 hour urine collection.1 In some very rare cases of severe

iodine cellular transport defect/damage, the absorbed iodine/iodide

is quantitatively excreted in the urine, even though the target

organs are very iodine deficient. We have reported only three cases

over the last three years.3,4 One case was studied in detail using

post-iodine load serial serum iodide levels before and after

supplementation with Vitamin C.4 The milder cases of iodide cellular

uptake defect/damage are more difficult to detect. We are currently

investigating the saliva iodide/serum iodide ratio as a means of

assessing iodide cellular transport effectiveness. In the only case

of symporter defect/damage assessed by the saliva/serum iodide ratio

so far5 this female patient had elevated serum fluoride levels (0.32

mg/L) compared to the normal range of 0.001 to 0.045 mg/L reported

in the literature.6 This level of serum fluoride of 0.32 mg/L is

observed in patients ingesting up to 10 mg per day.6 Prior to

Vitamin C at 3 grams per day, the saliva/serum ratio was 1.1 (saliva

0.081 mg/L and serum 0.073 mg/L) 24 hours after a load of 50 mg

iodine (4 tablets Iodoral®). After one month on Vitamin C, 3 grams

per day, and 4 tablets of Iodoral® per day, her saliva/serum ratio

increased to 47 (saliva 7.1 mg/L and serum 0.15 mg/L) 24 hrs

following the 50 mg iodine load. Her serum fluoride decreased to

0.13 mg/L... "

I found this info about iodine tests. Wonder if supplementing iodine

makes the test inaccurate?

http://www.mercksource.com/pp/us/cns/cns_hl_dorlands.jspzQzpgzEzzSzpp

docszSzuszSzcommonzSzdorlandszSzdorlandzSzdmd_t_05zPzhtm

" ...protein-bound iodine t. a formerly common thyroid function test

in which the amount of iodine firmly bound to protein in the serum

was determined by precipitating the proteins, yielding an estimate

of serum thyroid hormone concentration. Errors were introduced if

iodine compounds from nonthyroid sources were present... "

Ah, there's this by Abraham:

Serum inorganic iodide levels following ingestion of a tablet form

of Lugol solution: evidence for an enterohepatic circulation of

iodine.

http://optimox.com/pics/Iodine/IOD-09/IOD-9.htm

How long have you been taking iodine Abbe & how much do you take?

Did you do a loading test before you started?

>

> Test: Iodine Plasma or Serum

> Reference Range: 40 - 92 ug/L

> Units: ug/L

Result: Out of Range: 477

>

> Any comments? Abbe

[Guest guest]

Hello ,

I appreciate the effort but I do not believe these

articles are relevant to the blood test I reported on.

It does not appear anyone understands the Plasma or

Serum Test or its implications but that is no worse

than the loading test which results appear

inconsistent and do not seem to measure what they

purport to.

Abbe

--- jtb14789 <jtb14789@...> wrote:

> I don't know if this helps you with anything, but

> the VRP site

> mentions serum levels and how Vitamin C improved the

> iodine cellular

> transport defect:

>

> http://www.vrp.com/art/1797.asp?

> c=1160768232750 & k=/det/9139.asp & m=/ & p=no & s=0

> " ...Whole body sufficiency for iodine is arbitrarily

> defined as 90

> percent or more of the ingested iodine/iodide load

> (50 mg) recovered

> in the 24 hour urine collection.1 In some very rare

> cases of severe

> iodine cellular transport defect/damage, the

> absorbed iodine/iodide

> is quantitatively excreted in the urine, even though

> the target

> organs are very iodine deficient. We have reported

> only three cases

> over the last three years.3,4 One case was studied

> in detail using

> post-iodine load serial serum iodide levels before

> and after

> supplementation with Vitamin C.4 The milder cases of

> iodide cellular

> uptake defect/damage are more difficult to detect.

> We are currently

> investigating the saliva iodide/serum iodide ratio

> as a means of

> assessing iodide cellular transport effectiveness.

> In the only case

> of symporter defect/damage assessed by the

> saliva/serum iodide ratio

> so far5 this female patient had elevated serum

> fluoride levels (0.32

> mg/L) compared to the normal range of 0.001 to 0.045

> mg/L reported

> in the literature.6 This level of serum fluoride of

> 0.32 mg/L is

> observed in patients ingesting up to 10 mg per day.6

> Prior to

> Vitamin C at 3 grams per day, the saliva/serum ratio

> was 1.1 (saliva

> 0.081 mg/L and serum 0.073 mg/L) 24 hours after a

> load of 50 mg

> iodine (4 tablets Iodoral®). After one month on

> Vitamin C, 3 grams

> per day, and 4 tablets of Iodoral® per day, her

> saliva/serum ratio

> increased to 47 (saliva 7.1 mg/L and serum 0.15

> mg/L) 24 hrs

> following the 50 mg iodine load. Her serum fluoride

> decreased to

> 0.13 mg/L... "

>

> I found this info about iodine tests. Wonder if

> supplementing iodine

> makes the test inaccurate?

>

>

http://www.mercksource.com/pp/us/cns/cns_hl_dorlands.jspzQzpgzEzzSzpp

>

docszSzuszSzcommonzSzdorlandszSzdorlandzSzdmd_t_05zPzhtm

>

> " ...protein-bound iodine t. a formerly common

> thyroid function test

> in which the amount of iodine firmly bound to

> protein in the serum

> was determined by precipitating the proteins,

> yielding an estimate

> of serum thyroid hormone concentration. Errors were

> introduced if

> iodine compounds from nonthyroid sources were

> present... "

>

> Ah, there's this by Abraham:

>

> Serum inorganic iodide levels following ingestion of

> a tablet form

> of Lugol solution: evidence for an enterohepatic

> circulation of

> iodine.

> http://optimox.com/pics/Iodine/IOD-09/IOD-9.htm

>

> How long have you been taking iodine Abbe & how much

> do you take?

> Did you do a loading test before you started?

>

>

>

>

>

> >

> > Test: Iodine Plasma or Serum

> > Reference Range: 40 - 92 ug/L

> > Units: ug/L

> Result: Out of Range: 477

> >

> > Any comments? Abbe

>

>

>

>

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[Guest guest]

Ok, Abbe. Back to my original questions - How long have you been

taking iodine & how much do you take? Did you do the urine loading

test before you started? Do you have any other dietary, supplement

or environmental exposure to iodine (lots of time swimming at the

beach?), that would increase your iodine load?

I think knowing the circumstances around the test makes commenting

on the out-of-range reading more relevant.

Also, would having a problem with the sodium/iodine-transporter

system contribute to higher serum levels?

>

>

>

> Hello ,

>

> I appreciate the effort but I do not believe these

> articles are relevant to the blood test I reported on.

>

> It does not appear anyone understands the Plasma or

> Serum Test or its implications but that is no worse

> than the loading test which results appear

> inconsistent and do not seem to measure what they

> purport to.

>

> Abbe

[Guest guest]

Hi Abbe,

I don't know much about the blood test for iodine but thought it was

not considered to be as valuable by the iodine docs. I wish I could

remember why! But that said, based on the fact that I recall you have

been taking Iodoral, the results make sense to me since the range was

based on a population of people who were likely only getting roughly

the RDA (150mcg) of iodine. In other words, I would think anyone

supplementing iodine would be out of range like you were. Sorry I

don't have anything to back up my thoughts.

Best wishes,

Sharon

> Test: Iodine Plasma or Serum

>

> Reference Range: 40 - 92 ug/L

>

> Units: ug/L

>

> Result: Out of Range: 477

>

> Any comments?

[Guest guest]

Remember that the regular iodine tests are looking for people who get 50 - 150 mcg iodine per day -- i.e., people who get the official RDA levels for iodine. If you have been supplementing with any form of kelp, Iodoral, etc., you will test very high on these tests.

At the same time, you will probably test very low on the Iodine Loading Test. You will recall that when Abraham and Flechas were developing the Iodine Loading Test, they had difficulty finding a lab that could test in the ranges they wanted. They had to get a particular lab protocol developed and notify the lab ahead of time to run the test a different way. That is why they eventually developed the Flechas lab to deal with these tests.

I suspect that any of us who have been supplementing in the mg range would be "out of range" on regular tests.

Zoe

> > >> > Test: Iodine Plasma or Serum> > Reference Range: 40 - 92 ug/L> > Units: ug/L> Result: Out of Range: 477> > > > Any comments? Abbe

[Guest guest]

--- Zoe & <ZOEA@...> wrote:

> Remember that the regular iodine tests are looking

> for people who get 50 - 150 mcg iodine per day --

> i.e., people who get the official RDA levels for

> iodine. If you have been supplementing with any

> form of kelp, Iodoral, etc., you will test very high

> on these tests.

Yes, I realize I would not fit within the range for

the reasons you give. It is frustrating, however, not

to have a way to determine *any* meaning for that

number, other than it is high. When I asked my own

doctor what it meant, he looked at me and said: " It's

high. " Doh, right.

Before the loading test was developed what did they

rely on? There must be some data for the Plasma or

Serum test. The question is how to access it.

Abbe

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[Guest guest]

Hi ,

Approximately 3 months on 12.5 mg Iodoral/day. Never

did the loading test because by the time I was aware

of it I was already taking iodine. Then, it began to

appear the loading test is not consistent and seemed

questionable as to what exactly it is measuring. I

have not ruled out taking it, though. No other

exposure that I consider significant. Do not know

about the symporter aspect. I also take magnesium and

selenium (Brazil nuts), and Armour.

Abbe

--- jtb14789 <jtb14789@...> wrote:

> Ok, Abbe. Back to my original questions - How long

> have you been

> taking iodine & how much do you take? Did you do the

> urine loading

> test before you started? Do you have any other

> dietary, supplement

> or environmental exposure to iodine (lots of time

> swimming at the

> beach?), that would increase your iodine load?

>

> I think knowing the circumstances around the test

> makes commenting

> on the out-of-range reading more relevant.

>

> Also, would having a problem with the

> sodium/iodine-transporter

> system contribute to higher serum levels?

>

> >

>

> >

> >

> > Hello ,

> >

> > I appreciate the effort but I do not believe these

> > articles are relevant to the blood test I reported

> on.

> >

> > It does not appear anyone understands the Plasma

> or

> > Serum Test or its implications but that is no

> worse

> > than the loading test which results appear

> > inconsistent and do not seem to measure what they

> > purport to.

> >

> > Abbe

>

>

>

>

________________________________________________________________________________\

____

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[Guest guest]

Hi Abbe,

> Yes, I realize I would not fit within the range for

> the reasons you give. It is frustrating, however, not

> to have a way to determine *any* meaning for that

> number, other than it is high. When I asked my own

> doctor what it meant, he looked at me and said: " It's

> high. " Doh, right.

>

> Before the loading test was developed what did they

> rely on? There must be some data for the Plasma or

> Serum test. The question is how to access it.

I believe what they used to do is to treat the person based on their

symptoms and how they responded to the treatment. They didn't worry

about the labs that they didn't have, but just went ahead and tried

a " clinical trial " of things like iodine to see if it helped. That is

personally my favorite approach if. I think the labs are a nice

option for when you or your health care provider are not sure what

direction to take. Based on your other emails it seems like iodine

has helped you, so why worry about the labs?

Just my opinion of course!

Best wishes,

Sharon

[Guest guest]

Hi Sharon,

--- sharflin <sharflin@...> wrote:

> Hi Abbe,

>

> > Yes, I realize I would not fit within the range

> for

> > the reasons you give. It is frustrating, however,

> not

> > to have a way to determine *any* meaning for that

> > number, other than it is high. When I asked my

> own

> > doctor what it meant, he looked at me and said:

> " It's

> > high. " Doh, right.

> >

> > Before the loading test was developed what did

> they

> > rely on? There must be some data for the Plasma

> or

> > Serum test. The question is how to access it.

>

> I believe what they used to do is to treat the

> person based on their

> symptoms and how they responded to the treatment.

> They didn't worry

> about the labs that they didn't have, but just went

> ahead and tried

> a " clinical trial " of things like iodine to see if

> it helped. That is

> personally my favorite approach if. I think the labs

> are a nice

> option for when you or your health care provider are

> not sure what

> direction to take. Based on your other emails it

> seems like iodine

> has helped you, so why worry about the labs?

>

> Just my opinion of course!

>

> Best wishes,

> Sharon

Right. Previously I did not care about labs at all.

I thought Iodoral did help me. Right now, however, I

am, hopefully, recovering from a reaction to stopping

it. I have written about this in other messages. So,

I am concerned now as to what is going on. My new

doctor (the other retired) seems to be a quite a good

doctor but as yet does not seem to have much knowledge

in this area. That's not surprising few do.

Abbe

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