Re: Fw: [hypothyroidism] Iodine allergy

[Guest guest]

I'd like to thank Chuck for making me aware of this series of Japanese articles on iodine allergy. I've included abstracts below and added them to our links here:

Links > 10 Clinical Pearls > Iodine Allergies > Allergy Research

iodine/links/Clinical_Pearls_001138891653/Iodine_Allergies_001138752470/Allergy_Research_001145573253/

I'd be curious how the radiology group from UCSF in the link below would respond to those articles.

Iodine Allergy and Contrast Administration "Our purpose is to show that iodine does not confer a specific cross-reactivity between iodine-rich substances, that the cross-reactivity that does exist is nonspecific, and that the concept of iodine allergy is fallacious and may result in the inappropriate nonuse of IV contrast material in patients intolerant of antiseptics or seafood that contain iodine."

http://www.radiology.ucsf.edu/instruction/abdominal/ab_handbook/04-IodineAllergy.html

I don't know where Chuck got the following idea: "Inorganic iodine (I2) or iodide ion, thus _become_ organic as soon as they are taken internally." I have been trying to find good information on what happens to iodine/iodide once they are taken internally. The best information I have been able to find has been by Thrall, et al, and their work is very preliminary. I would be interested in Chuck's sources on this.

Thanks for posting this, Gracia.

Zoe

*******************************************************

Studies on experimental iodine allergy: 1. Antigen recognition of guinea pig anti-iodine antibody. Shionoya H, Sugihara Y, Okano K, Sagami F, Mikami T, Katayama K.. Japan. 2004. Article.

"It has generally been thought that iodine allergy is cross-sensitive to various iodine-containing chemicals. However, this concept seems to deviate from the immunological principle that immune recognition is specific. To solve this contradiction, we hypothesize that iodine allergy is an immunological reaction to iodinated autologous proteins produced in vivo by iodination reaction from various iodine-containing chemicals. Antisera to iodine were obtained from guinea pigs immunized subcutaneously with iodine-potassium iodide solution emulsified in complete Freund's adjuvant (CFA). The specificity of guinea pig anti-iodine antiserum was determined by enzyme-linked immunosorbent assay (ELISA) inhibition experiments using microplates coated with iodinated guinea pig serum albumin (I-GSA). Antibody activities were inhibited by I-GSA, diiodo-L-tyrosine, and thyroxine, but not by potassium iodide, monoiodo-L-tyrosine, 3,5,3'-triiodothyronine, monoiodo-L-histidine, or diiodo-L-histidine, or by ionic or non-ionic iodinated contrast media. The results that antigen recognition of anti-iodine antibody is specific to iodinated protein support our hypothesis. While protein iodination usually takes place both at histidine residues as well as at tyrosine residues, only iodinated tyrosine acted as an antigenic determinant and no antibody activities to iodinated histidine were detected in our experimental iodine allergy model."

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Retrieve & dopt=AbstractPlus & list_uids=15206581 & query_hl=2 & itool=pubmed_docsum

Studies on experimental iodine allergy: 2. Iodinated protein antigens and their generation from inorganic and organic iodine-co [iodine-containing chemicals.] Shionoya H, Sugihara Y, Okano K, Sagami F, Mikami T, Katayama K., Japan. 2004. Article.

"We hypothesize that iodine allergy is an immune response to iodinated autologous proteins generated in vivo from iodine-containing organic and inorganic chemicals. In this report, effects of protein iodination on elicitogenic activity in guinea pig iodine allergy model and iodinated protein antigen generation in vitro from iodine-containing chemicals were investigated. Active cutaneous anaphylaxis (ACA) and delayed-type hypersensitivity (DTH) tests were performed in guinea pigs immunized with iodine. The amount of iodine (I2) reacted to proteins for giving them an eliciting activity of ACA was > or = 0.15 micromol for 1 mg of albumin. DTH reactions were provoked by intradermal injection of 10(6) PECs reacted with > or = 0.075 micromol of I2. I2 was generated from a potassium iodide (KI) solution or iodinated contrast media by UV light irradiation. X-ray irradiation of KI and iodinated contrast media in the presence of protein resulted in the generation of iodinated protein antigens. The generation of iodinated protein antigens was inhibited in the presence of reducing agents. Therefore, it is noteworthy that iodine allergy of the present hypothesis is dependent on reactive oxygens. By presenting these ex vivo and in vitro data, we discuss the possibilities for the generation of iodinated protein antigens in vivo."

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=15206582 & dopt=Abstract

Studies on experimental iodine allergy: 3. Low molecular weight elicitogenic antigens of iodine allergy. Sugihara Y, Shionoya H, Okano K, Sagami F, Mikami T, Katayama K.. Japan. 2004. Article.

"We hypothesize that iodine allergy is an immune response to iodinated self proteins produced in vivo from various iodine-containing chemicals. Since an antigenic determinant of experimental iodine allergy is diiodotyrosine (DIT), we designed low molecular weight DIT derivatives having provocative antigenicity without sensitizing immunogenicity. Tetraiododityrosine and hexaiodotrityrosine provoked dose-dependent skin reactions in guinea pigs previously immunized with iodine. No guinea pigs immunized with hexaiodotrityrosine showed anaphylactic reaction by i.v. challenge with hexaiodotrityrosine and none of their antisera showed positive passive cutaneous anaphylaxis (PCA) reaction in guinea pigs, indicating the non-immunogenic nature of the compound. Erythrosine, one of the color additives having a structure common with DIT, was assessed for its immunological property. Enzyme-linked immunosorbent assay (ELISA) inhibition studies on erythrosine revealed that the inhibitory activity of erythrosine was stronger than that of DIT. Furthermore, erythrosine provoked a PCA reaction in animals sensitized with anti-iodine antisera. In conclusion, hexaiodotrityrosine is thought to be useful for skin testing of iodine allergy without any fear of sensitization to the allergen. Erythrosine was shown to provoke an experimental iodine allergy and, also, the relationships between the new concept of iodine allergy and features of clinical findings of adverse effects by iodocontrast media are discussed." http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Retrieve & dopt=AbstractPlus & list_uids=15206583 & query_hl=2 & itool=pubmed_docsum

Fw: Iodine allergy

can someone help me here?

gracia

Gracia wrote:> > > > the thing to realize is that this reaction is to the kind of iodine used > in the dyes (which is organic) as opposed to the kind of iodine our > bodies use (which is inorganic). No it is not. The inorganic iodine (or iodide) react with proteins in the victim, making an allergen out of the person's own chemistry. Inorganic iodine (I2) or iodide ion, thus _become_ organic as soon as they are taken internally. The distinction is rather moot except to indicate that the iodine is not already compounded with some other molecule, which might be even more problematic. People that react to iodide contrast agents will typically be even more sensitive to high molality dyes, but that is simply because the concentration of elemental iodine in them is higher. The source form is largely immaterial.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=15206582 & dopt=AbstractChuck

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[Guest guest]

I haven't plowed thru the links yet, but I found I'm allergic to the

contrast dye containing iodine that's used for CAT scan. But, I have

no trouble with the " normal " stuff.

The tissue around my eyes blew up like softballs when I had a CAT

scan for a head injury after a fall. But topical & vitamin iodine

has never bothered me. I've been taking Lugol's for 4 days & no

problems at all.

> Iodine Allergy and Contrast Administration

> " Our purpose is to show that iodine does not confer a specific

cross-reactivity between iodine-rich substances, that the cross-

reactivity that does exist is nonspecific, and that the concept of

iodine allergy is fallacious and may result in the inappropriate

nonuse of IV contrast material in patients intolerant of antiseptics

or seafood that contain iodine. "

>

> http://www.radiology.ucsf.edu/instruction/abdominal/ab_handbook/04-

IodineAllergy.html

>

>

> I don't know where Chuck got the following idea: " Inorganic

iodine (I2) or iodide ion, thus _become_ organic as soon as

> they are taken internally. " I have been trying to find good

information on what happens to iodine/iodide once they are taken

internally. The best information I have been able to find has been

by Thrall, et al, and their work is very preliminary. I would be

interested in Chuck's sources on this.

>

> Thanks for posting this, Gracia.

>

> Zoe

>

>

> *******************************************************

>

> Studies on experimental iodine allergy: 1. Antigen recognition of

guinea pig anti-iodine antibody.

> Shionoya H, Sugihara Y, Okano K, Sagami F, Mikami T, Katayama K..

Japan. 2004. Article.

>

> " It has generally been thought that iodine allergy is cross-

sensitive to various iodine-containing chemicals. However, this

concept seems to deviate from the immunological principle that

immune recognition is specific. To solve this contradiction, we

hypothesize that iodine allergy is an immunological reaction to

iodinated autologous proteins produced in vivo by iodination

reaction from various iodine-containing chemicals. Antisera to

iodine were obtained from guinea pigs immunized subcutaneously with

iodine-potassium iodide solution emulsified in complete Freund's

adjuvant (CFA). The specificity of guinea pig anti-iodine antiserum

was determined by enzyme-linked immunosorbent assay (ELISA)

inhibition experiments using microplates coated with iodinated

guinea pig serum albumin (I-GSA). Antibody activities were inhibited

by I-GSA, diiodo-L-tyrosine, and thyroxine, but not by potassium

iodide, monoiodo-L-tyrosine, 3,5,3'-triiodothyronine, monoiodo-L-

histidine, or diiodo-L-histidine, or by ionic or non-ionic iodinated

contrast media. The results that antigen recognition of anti-iodine

antibody is specific to iodinated protein support our hypothesis.

While protein iodination usually takes place both at histidine

residues as well as at tyrosine residues, only iodinated tyrosine

acted as an antigenic determinant and no antibody activities to

iodinated histidine were detected in our experimental iodine allergy

model. "

>

> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?

db=pubmed & cmd=Retrieve & dopt=AbstractPlus & list_uids=15206581 & query_hl=

2 & itool=pubmed_docsum

>

>

> Studies on experimental iodine allergy: 2. Iodinated protein

antigens and their generation from inorganic and organic iodine-co

> [iodine-containing chemicals.] Shionoya H, Sugihara Y, Okano K,

Sagami F, Mikami T, Katayama K., Japan. 2004. Article.

>

> " We hypothesize that iodine allergy is an immune response to

iodinated autologous proteins generated in vivo from iodine-

containing organic and inorganic chemicals. In this report, effects

of protein iodination on elicitogenic activity in guinea pig iodine

allergy model and iodinated protein antigen generation in vitro from

iodine-containing chemicals were investigated. Active cutaneous

anaphylaxis (ACA) and delayed-type hypersensitivity (DTH) tests were

performed in guinea pigs immunized with iodine. The amount of iodine

(I2) reacted to proteins for giving them an eliciting activity of

ACA was > or = 0.15 micromol for 1 mg of albumin. DTH reactions were

provoked by intradermal injection of 10(6) PECs reacted with > or =

0.075 micromol of I2. I2 was generated from a potassium iodide (KI)

solution or iodinated contrast media by UV light irradiation. X-ray

irradiation of KI and iodinated contrast media in the presence of

protein resulted in the generation of iodinated protein antigens.

The generation of iodinated protein antigens was inhibited in the

presence of reducing agents. Therefore, it is noteworthy that iodine

allergy of the present hypothesis is dependent on reactive oxygens.

By presenting these ex vivo and in vitro data, we discuss the

possibilities for the generation of iodinated protein antigens in

vivo. "

>

> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?

cmd=Retrieve & db=PubMed & list_uids=15206582 & dopt=Abstract

>

>

> Studies on experimental iodine allergy: 3. Low molecular weight

elicitogenic antigens of iodine allergy.

> Sugihara Y, Shionoya H, Okano K, Sagami F, Mikami T, Katayama K..

Japan. 2004. Article.

>

> " We hypothesize that iodine allergy is an immune response to

iodinated self proteins produced in vivo from various iodine-

containing chemicals. Since an antigenic determinant of experimental

iodine allergy is diiodotyrosine (DIT), we designed low molecular

weight DIT derivatives having provocative antigenicity without

sensitizing immunogenicity. Tetraiododityrosine and

hexaiodotrityrosine provoked dose-dependent skin reactions in guinea

pigs previously immunized with iodine. No guinea pigs immunized with

hexaiodotrityrosine showed anaphylactic reaction by i.v. challenge

with hexaiodotrityrosine and none of their antisera showed positive

passive cutaneous anaphylaxis (PCA) reaction in guinea pigs,

indicating the non-immunogenic nature of the compound. Erythrosine,

one of the color additives having a structure common with DIT, was

assessed for its immunological property. Enzyme-linked immunosorbent

assay (ELISA) inhibition studies on erythrosine revealed that the

inhibitory activity of erythrosine was stronger than that of DIT.

Furthermore, erythrosine provoked a PCA reaction in animals

sensitized with anti-iodine antisera. In conclusion,

hexaiodotrityrosine is thought to be useful for skin testing of

iodine allergy without any fear of sensitization to the allergen.

Erythrosine was shown to provoke an experimental iodine allergy and,

also, the relationships between the new concept of iodine allergy

and features of clinical findings of adverse effects by iodocontrast

media are discussed. "

> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?

db=pubmed & cmd=Retrieve & dopt=AbstractPlus & list_uids=15206583 & query_hl=

2 & itool=pubmed_docsum

>

>

> Fw: Iodine allergy

>

>

>

> can someone help me here?

> gracia

>

> Gracia wrote:

> >

> >

> >

> > the thing to realize is that this reaction is to the kind of

iodine used

> > in the dyes (which is organic) as opposed to the kind of

iodine our

> > bodies use (which is inorganic).

>

> No it is not. The inorganic iodine (or iodide) react with

proteins in

> the victim, making an allergen out of the person's own

chemistry.

> Inorganic iodine (I2) or iodide ion, thus _become_ organic as

soon as

> they are taken internally. The distinction is rather moot except

to

> indicate that the iodine is not already compounded with some

other

> molecule, which might be even more problematic. People that

react to

> iodide contrast agents will typically be even more sensitive to

high

> molality dyes, but that is simply because the concentration of

elemental

> iodine in them is higher. The source form is largely immaterial.

>

> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?

cmd=Retrieve & db=PubMed & list_uids=15206582 & dopt=Abstract

>

> Chuck

>

>

>

>

> -------------------------------------------------------------------

-----------

>

>

> No virus found in this incoming message.

> Checked by AVG Free Edition.

> Version: 7.1.408 / Virus Database: 268.13.6/486 - Release Date:

10/19/2006

>

>

>

> -------------------------------------------------------------------

-----------

>

>

> No virus found in this outgoing message.

> Checked by AVG Free Edition.

> Version: 7.1.408 / Virus Database: 268.13.6/486 - Release Date:

10/19/2006

>

[Guest guest]

I remember Alober opposed tooth & nail,

How on earth ............

one can have allergy to iodine ...........

===========================

Zoe & wrote:

I'd like to thank Chuck for making me aware of this series of

Japanese articles on iodine allergy. I've included abstracts below and

added them to our links here:

Links > 10 Clinical Pearls > Iodine Allergies > Allergy Research

iodine/links/Clinical_Pearls_001138891653/Iodine_Allergies_001138752470/Allergy_Research_001145573253/

I'd be curious how the radiology group from UCSF in the link

below would respond to those articles.

Iodine Allergy and Contrast Administration

"Our purpose is to show that

iodine does not confer a specific cross-reactivity between iodine-rich

substances, that the cross-reactivity that does exist is nonspecific,

and that the concept of iodine allergy is fallacious and may result in

the inappropriate nonuse of IV contrast material in patients intolerant

of antiseptics or seafood that contain iodine."

http://www.radiology.ucsf.edu/instruction/abdominal/ab_handbook/04-IodineAllergy.html

I don't know where Chuck got

the following idea: "Inorganic iodine (I2) or iodide ion, thus

_become_ organic as soon as

they are taken internally." I have been trying to find good

information on what happens to iodine/iodide once they are taken

internally. The best information I have been able to find has been by

Thrall, et al, and their work is very preliminary. I would be

interested in Chuck's sources on this.

Thanks for posting this, Gracia.

Zoe

*******************************************************

Studies on experimental iodine allergy: 1.

Antigen recognition of guinea pig anti-iodine antibody.

Shionoya H, Sugihara Y,

Okano K, Sagami F, Mikami T, Katayama K.. Japan. 2004. Article.

"It has generally been thought that iodine allergy is

cross-sensitive to various iodine-containing chemicals. However, this

concept seems to deviate from the immunological principle that immune

recognition is specific. To solve this contradiction, we hypothesize that iodine allergy is an

immunological reaction to iodinated autologous proteins produced in

vivo by iodination reaction from various iodine-containing chemicals.

Antisera to iodine were obtained from guinea pigs immunized

subcutaneously with iodine-potassium iodide solution emulsified in

complete Freund's adjuvant (CFA). The specificity of guinea pig

anti-iodine antiserum was determined by enzyme-linked immunosorbent

assay (ELISA) inhibition experiments using microplates coated with

iodinated guinea pig serum albumin (I-GSA). Antibody activities were

inhibited by I-GSA, diiodo-L-tyrosine, and thyroxine, but not by

potassium iodide, monoiodo-L-tyrosine, 3,5,3'-triiodothyronine,

monoiodo-L-histidine, or diiodo-L-histidine, or by ionic or

non-ionic iodinated contrast media. The results that antigen

recognition of anti-iodine antibody is specific to iodinated protein

support our hypothesis. While protein iodination usually takes place

both at histidine residues as well as at tyrosine residues, only

iodinated tyrosine acted as an antigenic determinant and no antibody

activities to iodinated histidine were detected in our experimental

iodine allergy model."

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Retrieve & dopt=AbstractPlus & list_uids=15206581 & query_hl=2 & itool=pubmed_docsum

Studies on experimental iodine allergy: 2.

Iodinated protein antigens and their generation from inorganic and

organic iodine-co

[iodine-containing

chemicals.] Shionoya H, Sugihara Y, Okano K, Sagami F, Mikami T,

Katayama K., Japan. 2004. Article.

"We hypothesize that

iodine allergy is an immune response to iodinated autologous proteins

generated in vivo from iodine-containing organic and inorganic

chemicals. In this report, effects of protein

iodination on elicitogenic activity in guinea pig iodine allergy model

and iodinated protein antigen generation in vitro from

iodine-containing chemicals were investigated. Active cutaneous

anaphylaxis (ACA) and delayed-type hypersensitivity (DTH) tests were

performed in guinea pigs immunized with iodine. The amount of iodine

(I2) reacted to proteins for giving them an eliciting activity of ACA

was > or = 0.15 micromol for 1 mg of albumin. DTH reactions were

provoked by intradermal injection of 10(6) PECs reacted with > or =

0.075 micromol of I2. I2 was generated from a potassium iodide (KI)

solution or iodinated contrast media by UV light irradiation. X-ray

irradiation of KI and iodinated contrast media in the presence of

protein resulted in the generation of iodinated protein antigens. The

generation of iodinated protein antigens was inhibited in the presence

of reducing agents. Therefore, it is noteworthy that iodine allergy of

the present hypothesis is dependent on reactive oxygens. By presenting

these ex vivo and in vitro data, we discuss the possibilities for the

generation of iodinated protein antigens in vivo."

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=15206582 & dopt=Abstract

Studies on experimental iodine allergy: 3. Low

molecular weight elicitogenic antigens of iodine allergy.

Sugihara Y, Shionoya H,

Okano K, Sagami F, Mikami T, Katayama K.. Japan. 2004. Article.

"We

hypothesize that iodine allergy is an immune response to iodinated self

proteins produced in vivo from various iodine-containing chemicals.

Since an antigenic determinant of experimental iodine allergy is

diiodotyrosine (DIT), we designed low molecular weight DIT derivatives

having provocative antigenicity without sensitizing immunogenicity.

Tetraiododityrosine and hexaiodotrityrosine provoked dose-dependent

skin reactions in guinea pigs previously immunized with iodine. No

guinea pigs immunized with hexaiodotrityrosine showed anaphylactic

reaction by i.v. challenge with hexaiodotrityrosine and none of their

antisera showed positive passive cutaneous anaphylaxis (PCA) reaction

in guinea pigs, indicating the non-immunogenic nature of the compound.

Erythrosine, one of the color additives having a structure common with

DIT, was assessed for its immunological property. Enzyme-linked

immunosorbent assay (ELISA) inhibition studies on erythrosine revealed

that the inhibitory activity of erythrosine was stronger than that of

DIT. Furthermore, erythrosine provoked a PCA reaction in animals

sensitized with anti-iodine antisera. In conclusion,

hexaiodotrityrosine is thought to be useful for skin testing of iodine

allergy without any fear of sensitization to the allergen. Erythrosine

was shown to provoke an experimental iodine allergy and, also, the

relationships between the new concept of iodine allergy and features of

clinical findings of adverse effects by iodocontrast media are

discussed."

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Retrieve & dopt=AbstractPlus & list_uids=15206583 & query_hl=2 & itool=pubmed_docsum

Fw: Iodine allergy

can someone help me here?

gracia

Gracia wrote:

>

>

>

> the thing to realize is that this reaction is to the kind of

iodine used

> in the dyes (which is organic) as opposed to the kind of iodine

our

> bodies use (which is inorganic).

No it is not. The inorganic iodine (or iodide) react with proteins in

the victim, making an allergen out of the person's own chemistry.

Inorganic iodine (I2) or iodide ion, thus _become_ organic as soon as

they are taken internally. The distinction is rather moot except to

indicate that the iodine is not already compounded with some other

molecule, which might be even more problematic. People that react to

iodide contrast agents will typically be even more sensitive to high

molality dyes, but that is simply because the concentration of

elemental

iodine in them is higher. The source form is largely immaterial.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=15206582 & dopt=Abstract

Chuck

[Guest guest]

It is possible, albeit rare, to have an iodine allergy. An allergy can take any form, including a rash, fatigue, congestion, headache and fever. NAET, an acupressure technique has been useful in some patients to help them overcome an allergy to iodine. See Dr. Brownstein's book "Iodine, Why You Need It, Why You Can't Live Without It" Refer to page 150-152 Michiganmedmidas <medmidas@...> wrote: I remember Alober opposed tooth &

nail,How on earth ............one can have allergy to iodine ...........===========================Zoe & wrote: I'd like to thank Chuck for making me aware of this series of Japanese articles on iodine allergy. I've included abstracts below and added them to our links here: Links > 10 Clinical Pearls > Iodine Allergies > Allergy Research iodine/links/Clinical_Pearls_001138891653/Iodine_Allergies_001138752470/Allergy_Research_001145573253/ I'd be curious how the radiology group from UCSF in the link below would respond to those articles. Iodine Allergy and Contrast Administration "Our purpose is to show that iodine does not confer a specific cross-reactivity between iodine-rich substances, that the cross-reactivity that does exist is

nonspecific, and that the concept of iodine allergy is fallacious and may result in the inappropriate nonuse of IV contrast material in patients intolerant of antiseptics or seafood that contain iodine." http://www.radiology.ucsf.edu/instruction/abdominal/ab_handbook/04-IodineAllergy.html I don't know where Chuck got the following idea: "Inorganic iodine (I2) or iodide ion, thus _become_ organic as soon as they are taken internally." I have been trying to find good information on what happens to

iodine/iodide once they are taken internally. The best information I have been able to find has been by Thrall, et al, and their work is very preliminary. I would be interested in Chuck's sources on this. Thanks for posting this, Gracia. Zoe ******************************************************* Studies on experimental iodine allergy: 1. Antigen recognition of guinea pig anti-iodine antibody. Shionoya H, Sugihara Y, Okano K, Sagami F, Mikami T, Katayama K.. Japan. 2004. Article. "It has generally been thought that iodine allergy is cross-sensitive to various iodine-containing chemicals. However, this concept seems to deviate from the immunological principle that immune recognition is specific. To solve this contradiction, we hypothesize that iodine allergy is an immunological

reaction to iodinated autologous proteins produced in vivo by iodination reaction from various iodine-containing chemicals. Antisera to iodine were obtained from guinea pigs immunized subcutaneously with iodine-potassium iodide solution emulsified in complete Freund's adjuvant (CFA). The specificity of guinea pig anti-iodine antiserum was determined by enzyme-linked immunosorbent assay (ELISA) inhibition experiments using microplates coated with iodinated guinea pig serum albumin (I-GSA). Antibody activities were inhibited by I-GSA, diiodo-L-tyrosine, and thyroxine, but not by potassium iodide, monoiodo-L-tyrosine, 3,5,3'-triiodothyronine, monoiodo-L-histidine, or diiodo-L-histidine, or by ionic or non-ionic iodinated contrast media. The results that antigen recognition of anti-iodine antibody is specific to iodinated protein support our hypothesis. While protein iodination usually takes place both at histidine residues as well as at tyrosine

residues, only iodinated tyrosine acted as an antigenic determinant and no antibody activities to iodinated histidine were detected in our experimental iodine allergy model." http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Retrieve & dopt=AbstractPlus & list_uids=15206581 & query_hl=2 & itool=pubmed_docsum Studies on experimental iodine allergy: 2. Iodinated protein antigens and their generation from inorganic and organic iodine-co [iodine-containing chemicals.] Shionoya H, Sugihara Y, Okano K, Sagami F, Mikami T, Katayama K., Japan. 2004. Article. "We hypothesize that iodine allergy is an immune response to iodinated autologous proteins generated in vivo from iodine-containing organic and inorganic chemicals. In this report, effects of protein iodination on elicitogenic activity in guinea

pig iodine allergy model and iodinated protein antigen generation in vitro from iodine-containing chemicals were investigated. Active cutaneous anaphylaxis (ACA) and delayed-type hypersensitivity (DTH) tests were performed in guinea pigs immunized with iodine. The amount of iodine (I2) reacted to proteins for giving them an eliciting activity of ACA was > or = 0.15 micromol for 1 mg of albumin. DTH reactions were provoked by intradermal injection of 10(6) PECs reacted with > or = 0.075 micromol of I2. I2 was generated from a potassium iodide (KI) solution or iodinated contrast media by UV light irradiation. X-ray irradiation of KI and iodinated contrast media in the presence of protein resulted in the generation of iodinated protein antigens. The generation of iodinated protein antigens was inhibited in the presence of reducing agents. Therefore, it is noteworthy that iodine allergy of the present hypothesis is dependent on reactive oxygens. By presenting these ex

vivo and in vitro data, we discuss the possibilities for the generation of iodinated protein antigens in vivo." http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=15206582 & dopt=Abstract Studies on experimental iodine allergy: 3. Low molecular weight elicitogenic antigens of iodine allergy. Sugihara Y, Shionoya H, Okano K, Sagami F, Mikami T, Katayama K.. Japan. 2004. Article. "We hypothesize that iodine allergy is an immune response to iodinated self proteins produced in vivo from various iodine-containing chemicals. Since an antigenic determinant of experimental iodine allergy

is diiodotyrosine (DIT), we designed low molecular weight DIT derivatives having provocative antigenicity without sensitizing immunogenicity. Tetraiododityrosine and hexaiodotrityrosine provoked dose-dependent skin reactions in guinea pigs previously immunized with iodine. No guinea pigs immunized with hexaiodotrityrosine showed anaphylactic reaction by i.v. challenge with hexaiodotrityrosine and none of their antisera showed positive passive cutaneous anaphylaxis (PCA) reaction in guinea pigs, indicating the non-immunogenic nature of the compound. Erythrosine, one of the color additives having a structure common with DIT, was assessed for its immunological property. Enzyme-linked immunosorbent assay (ELISA) inhibition studies on erythrosine revealed that the inhibitory activity of erythrosine was stronger than that of DIT. Furthermore, erythrosine provoked a PCA reaction in animals sensitized with anti-iodine antisera. In conclusion, hexaiodotrityrosine is thought to be

useful for skin testing of iodine allergy without any fear of sensitization to the allergen. Erythrosine was shown to provoke an experimental iodine allergy and, also, the relationships between the new concept of iodine allergy and features of clinical findings of adverse effects by iodocontrast media are discussed." http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Retrieve & dopt=AbstractPlus & list_uids=15206583 & query_hl=2 & itool=pubmed_docsum Fw: Iodine allergy can someone help me here? gracia Gracia wrote:> > > > the thing to realize is that this reaction is to the kind of iodine used > in the dyes (which is organic) as opposed to the kind of iodine our > bodies use (which is

inorganic). No it is not. The inorganic iodine (or iodide) react with proteins in the victim, making an allergen out of the person's own chemistry. Inorganic iodine (I2) or iodide ion, thus _become_ organic as soon as they are taken internally. The distinction is rather moot except to indicate that the iodine is not already compounded with some other molecule, which might be even more problematic. People that react to iodide contrast agents will typically be even more sensitive to high molality dyes, but that is simply because the concentration of elemental iodine in them is higher. The source form is largely immaterial.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=15206582 & dopt=AbstractChuck

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[Guest guest]

Does anyone know what NAET is? What do they do for the technique. I have the training books but haven't gotten into it yet. Dr. Brownstein suggested that I have some NAET treatments for my mercury sensitivity. I am HORRIBLE since removing my amalgams. I cannot go to my mercury free dentist office and the other day my DH broke a fluorescent light and I had a reaction to the vapor from that. It's getting harder to deal with. I have looked at the NAET website but there doesn't seem to be much info on what they do. Just wondering if anyone had done it.

It is possible, albeit rare, to have an iodine allergy. An allergy can take any form, including a rash, fatigue, congestion, headache and fever. NAET, an acupressure technique has been useful in some patients to help them overcome an allergy to iodine.

See Dr. Brownstein's book "Iodine, Why You Need It, Why You Can't Live Without It"

Refer to page 150-152

Michigan

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..

[Guest guest]

,How do mean, horrible since your amalgam removal?LinnOn Oct 21, 2006, at 6:42 PM, ladybugsandbees wrote:Does anyone know what NAET is?  What do they do for the technique.  I have the training books but haven't gotten into it yet.  Dr. Brownstein suggested that I have some NAET treatments for my mercury sensitivity.  I am HORRIBLE since removing my amalgams.  I cannot go to my mercury free dentist office and the other day my DH broke a fluorescent light and I had a reaction to the vapor from that.  It's getting harder to deal with.  I have looked at the NAET website but there doesn't seem to be much info on what they do.  Just wondering if anyone had done it.  

[Guest guest]

I had no symptoms of a sensitivity to mercury prior to my removal. I had 12 amalgams in my mouth and other than getting a burning tongue when the last one was placed, I could come and go in a dental office with no issues.

Now, I spend any amount of time in a dental office (even my dentist which is mercury free) and I get a swollen tongue, headache and feel dizzy / wiggy. The first time it happened was my cleaning and I was there for 2 hours because my daughter had an appt too. I had a swollen tongue for 2 weeks and Dr. B thought it was bacterial. When the things he prescribed didn't work I decided to try chelation again as I had stopped for 14 days. I started and 1 day later the tongue was down to normal size again. I have been at the dentist 2 more times since then and each time end up with a swollen tongue and chelation brings it down.

Steph

,

How do mean, horrible since your amalgam removal?

Linn

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..

[Guest guest]

I am curious ...why do you think going to your mercury free dentist causes flare ups? Wondering what at the dentists office causes your tongue to swell every time you go?? Any ideas ? Michiganladybugsandbees <ladybugsandbees@...> wrote: Does anyone know what NAET is? What do they do for the technique. I have the training books but haven't gotten into it yet. Dr. Brownstein suggested that I have some

NAET treatments for my mercury sensitivity. I am HORRIBLE since removing my amalgams. I cannot go to my mercury free dentist office and the other day my DH broke a fluorescent light and I had a reaction to the vapor from that. It's getting harder to deal with. I have looked at the NAET website but there doesn't seem to be much info on what they do. Just wondering if anyone had done it. It is possible, albeit rare, to have an iodine allergy. An allergy can take any form, including a rash, fatigue, congestion, headache and fever. NAET, an acupressure technique has been useful in some patients to help them overcome

an allergy to iodine. See Dr. Brownstein's book "Iodine, Why You Need It, Why You Can't Live Without It" Refer to page 150-152 Michigan Messages in this topic (13) Reply (via web post) | Start a new topic .

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[Guest guest]

Mercury - it is in the air from the cleanings and some removals. The majority of his patients still have amalgams and when cleaned vapor is released. It is trapped in carpets and air ducts. Dr. B believes it is mercury as well. We will be doing some testing in the office to see what is happening. My dentist is looking into getting a vapor detector - another person on my chelation group was in his office and experienced a reaction as well. There are just some of us that are highly sensitive/ reactive.

Steph

I am curious ...why do you think going to your mercury free dentist causes flare ups?

Wondering what at the dentists office causes your tongue to swell every time you go?? Any ideas ?

Michigan

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[Guest guest]

Mark Leventer, MD, Grass Lake Medical Center, does NAET with good results. He is also trained in acupuncture and a few other modalities.

517 522-8403

www.grasslakemedicalcenter.com

mjh"The Basil Book"http://foxhillfarm.us/FireBasil/

Posted by: "ladybugsandbees" ladybugsandbees@... stephanie_a_buist

Sat Oct 21, 2006 4:45 pm (PST)

Does anyone know what NAET is? What do they do for the technique. I have the training books but haven't gotten into it yet. Dr. Brownstein suggested that I have some NAET treatments for my mercury sensitivity. I am HORRIBLE since removing my amalgams. I cannot go to my mercury free dentist office and the other day my DH broke a fluorescent light and I had a reaction to the vapor from that. It's getting harder to deal with. I have looked at the NAET website but there doesn't seem to be much info on what they do. Just wondering if anyone had done it.It is possible, albeit rare, to have an iodine allergy. An allergy can take any form, including a rash, fatigue, congestion, headache and fever. NAET, an acupressure technique has been useful in some patients to help them overcome an allergy to iodine. See Dr. Brownstein's book "Iodine, Why You Need It, Why You Can't Live Without It"Refer to page 150-152 Michigan

[Guest guest]

Dr. Brownstein's office does NAET but it is 2 1/2 hours from my house and that is why I want to know what is involved. I have an office near my house that does it as well.

Mark Leventer, MD, Grass Lake Medical Center, does NAET with good results. He is also trained in acupuncture and a few other modalities.

517 522-8403

www.grasslakemedicalcenter.com

mjh"The Basil Book"http://foxhillfarm.us/FireBasil/

It is possible, albeit rare, to have an iodine allergy. An allergy can take any form, including a rash, fatigue, congestion, headache and fever. NAET, an acupressure technique has been useful in some patients to help them overcome an allergy to iodine. See Dr. Brownstein's book "Iodine, Why You Need It, Why You Can't Live Without It"Refer to page 150-152 Michigan

[Guest guest]

I hope it is not your dentist then that is characterizing his

office and practice as " mercury-free. " He may be treating you

w/o mercury, and he may be capable of filling removals, but it

hardly sounds as though he should be calling himself " mercury-

free. " You wouldn't have a chocolate manufacturer calling

their plant nut-allergen-free if they have runs with almonds

included, for example.

-

www.zenpawn.com/vegblog

>

> Mercury - it is in the air from the cleanings and some removals.

The majority of his patients still have amalgams and when cleaned

vapor is released. It is trapped in carpets and air ducts. Dr. B

believes it is mercury as well. We will be doing some testing in the

office to see what is happening. My dentist is looking into getting

a vapor detector - another person on my chelation group was in his

office and experienced a reaction as well. There are just some of us

that are highly sensitive/ reactive.

>

> Steph

>

>

>

>

> I am curious ...why do you think going to your mercury free

dentist causes flare ups?

> Wondering what at the dentists office causes your tongue to swell

every time you go?? Any ideas ?

>

> Michigan

>

>

>

>

>

>

> --------------------------------------------------------------------

----------

> All-new - Fire up a more powerful email and get

things done faster.

>

[Guest guest]

He is "mercury free" because he does not place them. That is the terminology used for dentists that refuse to use amalgams. It is in no way an indication of the level of mercury in his office.

Re: Fw: Iodine allergy

I hope it is not your dentist then that is characterizing hisoffice and practice as "mercury-free." He may be treating youw/o mercury, and he may be capable of filling removals, but ithardly sounds as though he should be calling himself "mercury-free." You wouldn't have a chocolate manufacturer callingtheir plant nut-allergen-free if they have runs with almondsincluded, for example.-www.zenpawn.com/vegblog>> Mercury - it is in the air from the cleanings and some removals. The majority of his patients still have amalgams and when cleaned vapor is released. It is trapped in carpets and air ducts. Dr. B believes it is mercury as well. We will be doing some testing in the office to see what is happening. My dentist is looking into getting a vapor detector - another person on my chelation group was in his office and experienced a reaction as well. There are just some of us that are highly sensitive/ reactive.> > Steph> > > > > I am curious ...why do you think going to your mercury free dentist causes flare ups?> Wondering what at the dentists office causes your tongue to swell every time you go?? Any ideas ?> > Michigan> > > > > > > --------------------------------------------------------------------> All-new - Fire up a more powerful email and get things done faster.>

[Guest guest]

Hi ,

Sorry to read you are having a difficult time *right

now*.

I am a bit confused, though. Are you telling us that

having had the mercury amalgams removed your

sensitivty to mercury in the environment has increased

to a point where you are uncomfortable? Or, are you

saying iodine is causing it in some way?

Thanks,

Abbe

--- ladybugsandbees <ladybugsandbees@...>

wrote:

> Does anyone know what NAET is? What do they do for

> the technique. I have the training books but

> haven't gotten into it yet. Dr. Brownstein

> suggested that I have some NAET treatments for my

> mercury sensitivity. I am HORRIBLE since removing

> my amalgams. I cannot go to my mercury free dentist

> office and the other day my DH broke a fluorescent

> light and I had a reaction to the vapor from that.

> It's getting harder to deal with. I have looked at

> the NAET website but there doesn't seem to be much

> info on what they do. Just wondering if anyone had

> done it.

>

>

>

>

>

> It is possible, albeit rare, to have an iodine

> allergy. An allergy can take any form, including a

> rash, fatigue, congestion, headache and fever.

> NAET, an acupressure technique has been useful in

> some patients to help them overcome an allergy to

> iodine.

> See Dr. Brownstein's book " Iodine, Why You Need

> It, Why You Can't Live Without It "

> Refer to page 150-152

>

> Michigan

>

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> Start a new topic

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> Iodine

[Guest guest]

Steph

What do you use for your chelation?

Joe

Re: Fw: Iodine allergy

I had no symptoms of a sensitivity to mercury prior to my removal. I had 12

amalgams in my mouth and other than getting a burning tongue when the last

one was placed, I could come and go in a dental office with no issues.

Now, I spend any amount of time in a dental office (even my dentist which is

mercury free) and I get a swollen tongue, headache and feel dizzy / wiggy.

The first time it happened was my cleaning and I was there for 2 hours

because my daughter had an appt too. I had a swollen tongue for 2 weeks and

Dr. B thought it was bacterial. When the things he prescribed didn't work I

decided to try chelation again as I had stopped for 14 days. I started and

1 day later the tongue was down to normal size again. I have been at the

dentist 2 more times since then and each time end up with a swollen tongue

and chelation brings it down.

Steph

,

How do mean, horrible since your amalgam removal?

Linn

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Iodine

[Guest guest]

Our previous pediatric dentist explained the mercury-free business to

me...

He said that even if he no longer uses mercury - which he didn't -

that as long as mercury was ever used, there can be contamination,

until it is decontaminated (I don't know how that process occurs).

He was remodeling the office at the time & was doing whatever it took

to decontaminate the mercury.

Don't know if that's entirely the case or what...just a friendly anecdote.

>

> He is " mercury free " because he does not place them. That is the

terminology used for dentists that refuse to use amalgams. It is in

no way an indication of the level of mercury in his office.

>

[Guest guest]

My dentist has NEVER used mercury so it isn't in the office from that. I have done lots of studying on this because I am interested in it. There are many ways that the office is contaminated if they used it and then stopped and other ways if they never used it. Mercury is just wicked stuff and should not be used but our stupid government won't take a stand on it in our mouths.

Our previous pediatric dentist explained the mercury-free business tome...He said that even if he no longer uses mercury - which he didn't -that as long as mercury was ever used, there can be contamination,until it is decontaminated (I don't know how that process occurs).He was remodeling the office at the time & was doing whatever it tookto decontaminate the mercury.Don't know if that's entirely the case or what...just a friendly anecdote.Messages in this topic (31) Reply (via web post) | Start a new topic

..

[Guest guest]

Have you already considered & discounted the cleaning ingredients used

during the polish? Or perhaps allergic reaction to the metal tools? (I don't

know what the metal is? nickel? stainless steel?) YOu could ask your dentist

for a dab of the polish, take home to try? I don't mean to suggest that

this may be the case because I have no idea.......but am just wondering if

you've also considered this.

Amy

ladybugsandbees wrote:

My dentist has NEVER used mercury so it isn't in the office from that.

I have done lots of studying on this because I am interested in it. There

are many ways that the office is contaminated if they used it and then stopped

and other ways if they never used it. Mercury is just wicked stuff and

should not be used but our stupid government won't take a stand on it in

our mouths.

#hd1{ font-family: Arial; font-weight: bold; color: #628c2a; font-size: 100%; line-height: 122%; } #ygrp-sponsor .ad a{ text-decoration: none; } #ygrp-sponsor

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[Guest guest]

Yes I have tried/tested everything. The difference is that this reaction happens whether I have work done or not. I just have to be at the office. Plus I had the same reaction when we broke the fluorescent bulb containing mercury in my home.

I am POSITIVE it is mercury and not something else. Dr. Brownstein is sure it is too. The fact that the chelation takes the symptoms away is enough evidence that it is mercury as well.

Steph

Re: Re: Fw: Iodine allergy

Have you already considered & discounted the cleaning ingredients used during the polish? Or perhaps allergic reaction to the metal tools? (I don't know what the metal is? nickel? stainless steel?) YOu could ask your dentist for a dab of the polish, take home to try? I don't mean to suggest that this may be the case because I have no idea.......but am just wondering if you've also considered this.Amy_._,_.___

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[Guest guest]

Oh, yes. Sorry. I recall you've already said this. I see why you come

to this conclusion. Also, in addition to mercury, I've read that chelation

will remove many (all?) minerals & metals. I hope your reactions subside.

It must be scary too.

Amy

ladybugsandbees wrote:

Yes I have tried/tested everything. The difference

is that this reaction happens whether I have work done or not. I just have

to be at the office. Plus I had the same reaction when we broke the fluorescent

bulb containing mercury in my home.

I am POSITIVE it is mercury and not something

else. Dr. Brownstein is sure it is too. The fact that the chelation takes

the symptoms away is enough evidence that it is mercury as well.

Steph

[Guest guest]

My dentist has NEVER used mercury so it isn't in the office from that. I have done lots of studying on this because I am interested in it. There are many ways that the office is contaminated if they used it and then stopped and other ways if they never used it. Mercury is just wicked stuff and should not be used but our stupid government won't take a stand on it in our mouths.

Has your dentist removed or replaced amalgam fillings? If amalgam is drilled into, a lot of mercury vapor will be released into the ambient air and then settle all over and especially into carpeting and upholstery.

Lynn

[Guest guest]

The only chelation that strips minerals is IV chelation. DMSA does not do that. I take many many supplements and am monitored by an ND & MD that specializes in chelation therapy for heavy metals.

Steph

Oh, yes. Sorry. I recall you've already said this. I see why you come to this conclusion. Also, in addition to mercury, I've read that chelation will remove many (all?) minerals & metals. I hope your reactions subside. It must be scary too.Amy

[Guest guest]

Oh Steph, I'm so sorry you're having such reactions. Why do you think that is? I think I'll keep my teeth as is, or just have the entire sucker yanked out, rather than removing fillings.

I'm sorry I've never had NAET done, but I do hear that it is effective.

Best,http://www.ChestnutHillDesigns.comhttp://www.CurlyRescue.com

Does anyone know what NAET is? What do they do for the technique. I have the training books but haven't gotten into it yet. Dr. Brownstein suggested that I have some NAET treatments for my mercury sensitivity. I am HORRIBLE since removing my amalgams. I cannot go to my mercury free dentist office and the other day my DH broke a fluorescent light and I had a reaction to the vapor from that. It's getting harder to deal with. I have looked at the NAET website but there doesn't seem to be much info on what they do. Just wondering if anyone had done it.