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Re: Re: Phone consult with Flechas about Iodine loss- Gene silencing

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Could you tell me what your hashi symtoms are. What type of thyroid meds to you take. Are you on amour? Do you have any depression and anxiety. If so what do you do for it.

What ways are you controlling your's at this time or are you. Do you still deal with the hyper and hypo symtoms.

Sorry for all the questions. Maybe you are doing something I have no clue about. I work and sometimes trying to do all the research and have the symtoms is difficult. Are you able to work?

Sometimes I get scared and think that I won't be able to. Sometimes is takes me days to recover from working. I also have adrenal problems. Do you? I don't know which one really takes me down but it is scary when it happens.

My daughter who is in college carries a lot of stuff that I just can't do.

Thanks

Ellen

Re: Phone consult with Flechas about Iodine loss- Gene silencing

I am trying to understand it also. Genes can be silenced by DNA methylation. A cancer cansilence the tumor surpressor gene in a cell through methylation... so the cell `forgets' how tofight... the search is on in gene therapy to find the way to re-allow gene expression in thesetypes of cancer cells... to wake it up. There seems to be different ways to approach this...byadministering drugs or unblocking agents, by adding genetically altered genes and nutrition,supplements. Gene therapy beats skin cancer in two men: study"the white blood cells had been armed with genes to spark production of proteins called T-cellreceptors. Those receptors recognized molecules on the melanoma cells and directed the white bloodcells to destroy the cancer"http://news./s/nm/20060831/hl_nm/cancer_genes_dcHere is a patent for an unblocking agent."administering an unblocking agent to the cancerous cell harboring a gene encoding the responseelement, thereby resulting in the expression of the response element."http://www.pharmcast.com/Patents100/Yr2006/April2006/041806/7029879_Iodine041806.htmNutrigenomic is the avenue that Dr. Flechas suggested. Research started in 2000 and is heatingup. Nutrigenomic is the avenue that uses specialized use of nutrition and natural supplements totry to manipulate the genes. He suggested phosphatylcholine (PC) and Betaine to silence theautoimmune gene that causes Hashimoto's. http://nutrigenomics.ucdavis.edu/nutrigenomics/index.cfm?objectid=972E8D2E-65B3-C1E7-0B3AE16C9F563594http://www.scienceblog.com/community/older/2003/D/20031874.htmlPhosphatylcholine (PC)PC is an essential fatty acid with a CHOLINE molecule that has a high concentration in thethyroid. It is chemically the same as lecithin. Nervous and circulatory lecithin is produced bythe liver if the diet is adequate. It is needed by every cell in the body and is a key buildingblock of cell membranes; without it, they would harden. Lecithin protects cells from oxidation andlargely comprises the protective sheaths surrounding the brain. BETAINE aka Trimethylglycine (TMG)functions very closely with CHOLINE, folic acid, vitamin B12 and S-adenosyl methionine SAMe. Allof these compounds function as "methyl donors." They carry and donate methyl functional groups tofacilitate necessary chemical processes. The donation of methyl groups is important to properliver function, cellular replication, and detoxification reactions. TMG also plays a role in themanufacture of carnitine and serves to protect the kidneys from damage.I have not found a reference yet that links these two supplements as to targeting the gene that isresponsible for Hashimoto's. I will if it exists. It is absolutely involving the use of fattyacids it seems to me...at this stage in my research anyway. I plan on calling Flechas as soon asI can learn enough as to not sound like a complete idiot on the subject. I plan on trying it assoon as the supplements get here. I'll keep you all posted as to whether or not the TPOanti-bodies fall."Nutrigenomic approach to understanding the mechanisms by which dietary long-chain fatty acidsinduce gene signals and control mechanisms involved in carcinogenesis."http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=14698023 & dopt=AbstractNutrigenomic explanation for the beneficial effects of fish oil on cognitive function http://www.ajcn.org/cgi/reprint/81/6/1453-a--- mem_mem_me <maryellenmubellsouth (DOT) net> wrote:> I have hashi's...can you explain how to lower the anitbodies with DNA> Methylation. What is that....--> > > > - In iodine , <kennio@...> wrote:> >> > Dr. Flechas called and seemed to be familiar with situation I am in.> After months of> > supplementing 50mg of Iodine I have actually lost about 20% of my> bodies iodine saturation.> > > > He said that I have a diminished iodine transport due to an> sodium/iodide symporter defect and> > bromide overload. He said he has seen the symporter defect cause> purging of existing Iodine> > stores in individuals with this problem while mega-dosing.> > > > "Although congenital hypothyroidism due to sodium/iodide symporter> defect is extremely rare,> > milder forms of iodine/iodide transport defect/damage throughout the> whole body may be more common> > and undetected"> > > > http://optimox.com/pics/Iodine/IOD-13/IOD_13.htm> > > > "If a patient has not taken iodine in significant amounts prior to> this test and the test shows> > greater than 90 percent excretion, one then needs to consider that> this individual has a> > sodium/iodide symporter defect. We now have done over 7,000 tests. A> major symporter defect is> > detected in about every 2,000 tests. If this defect is present,> special considerations must be> > given to try and get the defect repaired. A complete nutritional> program is recommended. We have> > previously reported improvement of a cellular transport defect for> iodine following Vitamin C> > supplementation."> > > >> http://www.vrp.com/art/1797.asp?c=1155970867437 & k=/det/9140.asp & m=/ & p=no & s=0> > > > He recommended I restart Iodine a few days after I start 1 teaspoon> of Keltic Sea Salt a day,> > taken along with 1500MG of Ester-C twice a day. The combination of> the sodium with the Iodine is> > an attempt to dislodge the Bromide from the defective receptors.> > > > He also mentioned I look into DNA Methylation to silence the gene> for autoimmunity (hashimoto's in> > my case). He recommended I take Phosphatidylcholine 385 mg,> softgels- 2 twice daily AND Betaine> > Free Base 1/2 teaspoon daily and monitor my TPO anti-bodies> frequently as it should be coming down> > while on the regimen for gene silencing. Both the Iodine and the> gene silencing supplements can be> > taken at the same time. I've ordered the supplements, so I will> keep you all posted. > > > > __________________________________________________> >

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I HAD the worst depression of my life and panic attacks/anxiety primarily BEFORE

I was taking

thyroid hormone before I knew what was wrong. The symptoms and severity you

experience sound

like undertreated hypothyroidism; although I would also suspect a severe

magnesium deficiency.

II take Levoxyl 125mcg. have tried Armour many times; I was on it again for the

last 2 weeks and

even had a compounding pharmacy make me a custom blend. Others suggest that it

would help the

only real symptom I have left and that is, exercise induced fatigue. The truth

is, I just don't

feel good when I take Armour. In the last two weeks of taking it I have lost so

much hair that I

just had to stop. I have never been this bald before, I just hope it all grows

back....it usually

does.

However, while on Levoxyl I went on vacation recently and ended up walking 10-15

miles a day and

started to go hypothyroid with hair loss (including on legs). My blood work on

levoxyl seems fine

TSH 1.77 Free T3 304 (230-420) Free T4 1.4 (0.8-1.8). Maybe I don't need the

extra T3 that Armour

provides?? I just started taking an adrenal support supplement to see if things

improve

exercise-wise. I also take a pituitary glandular supplement. I take Cod liver

oil and EPA/DHA

(fish oil) supplements and they have totally solved the dry hair (what I have

left) and the dry

skin problem.

Hypothyroidism can cause magnesium deficiency and apparently an essential fatty

acid deficiency

and the symptoms to BOTH are anxiety and/or depression. When I started

supplementing magnesium

glycinate these symptoms lessened drastically in severity especially when my

thyroid was

untreated. It is absolutely a necessary mineral for those with thyroid disease.

Try this test to

see how you score.

http://www.thewayup.com/newsletters/081501.htm

I would get a RBC analysis (red blood cell)

http://doctorsdata.com/repository.asp?id=1273 to

determine your mineral status. I think everyone should get some kind of

indication of their

status with a test like this. If your body won't tolerate a mineral that this

test shows you

lack...you need to find out why and find ways to tolerate it. Usually it is a

series of minerals

that need to be replaced at the same time so imbalances don't inadvertently

cause or expose other

mineral deficiencies.

I have never been officially hyperthyroid... I have taken too much hormone and

gotten jittery but

backed off on the dosage and felt better the next day. If I didn't work out so

much I would feel

almost totally normal at this point. My heart palpitations are a thing of the

past as are my

chest pains. I am here because I want to reverse my hashimoto's before my

thyroid is too damaged

for that to be possible. I thought I had tried Iodine mega-loading but the

latest test shows I

absorbed nothing during the three months... same problem I had with magnesium

initially! This

just means I will try harder.

I don't work now, I am taking time to solve my hashimoto's and to travel a bit.

I got my

supplements today and have begun the gene silencing therapy and I also am

mega-dosing 100mg of

iodine at this time! Boy am I going to have blood work and liver/kidney enzymes

done every 10

days or so. I am adventurous but try to be very cautious about it at the same

time...it's worked

for me so far.

--- Ellen <maryellenmu@...> wrote:

> Could you tell me what your hashi symtoms are. What type of thyroid meds to

you take. Are you

> on amour? Do you have any depression and anxiety. If so what do you do for

it.

>

> What ways are you controlling your's at this time or are you. Do you still

deal with the hyper

> and hypo symtoms.

>

> Sorry for all the questions. Maybe you are doing something I have no clue

about. I work and

> sometimes trying to do all the research and have the symtoms is difficult. Are

you able to work?

>

>

> Sometimes I get scared and think that I won't be able to. Sometimes is takes

me days to recover

> from working. I also have adrenal problems. Do you? I don't know which one

really takes me

> down but it is scary when it happens.

>

> My daughter who is in college carries a lot of stuff that I just can't do.

>

> Thanks

> Ellen

> Re: Phone consult with Flechas about Iodine loss- Gene

silencing

>

>

> I am trying to understand it also. Genes can be silenced by DNA methylation.

A cancer can

> silence the tumor surpressor gene in a cell through methylation... so the

cell `forgets' how

> to

> fight... the search is on in gene therapy to find the way to re-allow gene

expression in these

> types of cancer cells... to wake it up. There seems to be different ways to

approach this...by

> administering drugs or unblocking agents, by adding genetically altered

genes and nutrition,

> supplements.

>

> Gene therapy beats skin cancer in two men: study

>

> " the white blood cells had been armed with genes to spark production of

proteins called T-cell

> receptors. Those receptors recognized molecules on the melanoma cells and

directed the white

> blood

> cells to destroy the cancer "

>

> http://news./s/nm/20060831/hl_nm/cancer_genes_dc

>

> Here is a patent for an unblocking agent.

>

> " administering an unblocking agent to the cancerous cell harboring a gene

encoding the

> response

> element, thereby resulting in the expression of the response element. "

>

>

http://www.pharmcast.com/Patents100/Yr2006/April2006/041806/7029879_Iodine041806\

..htm

>

> Nutrigenomic is the avenue that Dr. Flechas suggested. Research started in

2000 and is heating

> up. Nutrigenomic is the avenue that uses specialized use of nutrition and

natural supplements

> to

> try to manipulate the genes. He suggested phosphatylcholine (PC) and Betaine

to silence the

> autoimmune gene that causes Hashimoto's.

>

>

>

http://nutrigenomics.ucdavis.edu/nutrigenomics/index.cfm?objectid=972E8D2E-65B3-\

C1E7-0B3AE16C9F563594

> http://www.scienceblog.com/community/older/2003/D/20031874.html

>

> Phosphatylcholine (PC)

> PC is an essential fatty acid with a CHOLINE molecule that has a high

concentration in the

> thyroid. It is chemically the same as lecithin. Nervous and circulatory

lecithin is produced

> by

> the liver if the diet is adequate. It is needed by every cell in the body

and is a key

> building

> block of cell membranes; without it, they would harden. Lecithin protects

cells from oxidation

> and

> largely comprises the protective sheaths surrounding the brain.

>

> BETAINE aka Trimethylglycine (TMG)

> functions very closely with CHOLINE, folic acid, vitamin B12 and S-adenosyl

methionine SAMe.

> All

> of these compounds function as " methyl donors. " They carry and donate methyl

functional groups

> to

> facilitate necessary chemical processes. The donation of methyl groups is

important to proper

> liver function, cellular replication, and detoxification reactions. TMG also

plays a role in

> the

> manufacture of carnitine and serves to protect the kidneys from damage.

>

> I have not found a reference yet that links these two supplements as to

targeting the gene

> that is

> responsible for Hashimoto's. I will if it exists. It is absolutely involving

the use of fatty

> acids it seems to me...at this stage in my research anyway. I plan on

calling Flechas as soon

> as

> I can learn enough as to not sound like a complete idiot on the subject. I

plan on trying it

> as

> soon as the supplements get here. I'll keep you all posted as to whether or

not the TPO

> anti-bodies fall.

>

> " Nutrigenomic approach to understanding the mechanisms by which dietary

long-chain fatty acids

> induce gene signals and control mechanisms involved in carcinogenesis. "

>

>

>

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=1\

4698023 & dopt=Abstract

>

> Nutrigenomic explanation for the beneficial effects of fish oil on cognitive

function

>

> http://www.ajcn.org/cgi/reprint/81/6/1453-a

>

>

> --- mem_mem_me <maryellenmu@...> wrote:

>

> > I have hashi's...can you explain how to lower the anitbodies with DNA

> > Methylation. What is that....--

> >

> >

> >

> > - In iodine , <kennio@...> wrote:

> > >

> > > Dr. Flechas called and seemed to be familiar with situation I am in.

> > After months of

> > > supplementing 50mg of Iodine I have actually lost about 20% of my

> > bodies iodine saturation.

> > >

> > > He said that I have a diminished iodine transport due to an

> > sodium/iodide symporter defect and

> > > bromide overload. He said he has seen the symporter defect cause

> > purging of existing Iodine

> > > stores in individuals with this problem while mega-dosing.

> > >

> > > " Although congenital hypothyroidism due to sodium/iodide symporter

> > defect is extremely rare,

> > > milder forms of iodine/iodide transport defect/damage throughout the

> > whole body may be more common

> > > and undetected "

> > >

> > > http://optimox.com/pics/Iodine/IOD-13/IOD_13.htm

> > >

> > > " If a patient has not taken iodine in significant amounts prior to

> > this test and the test shows

> > > greater than 90 percent excretion, one then needs to consider that

> > this individual has a

> > > sodium/iodide symporter defect. We now have done over 7,000 tests. A

> > major symporter defect is

> > > detected in about every 2,000 tests. If this defect is present,

> > special considerations must be

> > > given to try and get the defect repaired. A complete nutritional

> > program is recommended. We have

> > > previously reported improvement of a cellular transport defect for

> > iodine following Vitamin C

> > > supplementation. "

> > >

> > >

> >

http://www.vrp.com/art/1797.asp?c=1155970867437 & k=/det/9140.asp & m=/ & p=no & s=0

> > >

> > > He recommended I restart Iodine a few days after I start 1 teaspoon

> > of Keltic Sea Salt a day,

> > > taken along with 1500MG of Ester-C twice a day. The combination of

> > the sodium with the Iodine is

> > > an attempt to dislodge the Bromide from the defective receptors.

> > >

> > > He also mentioned I look into DNA Methylation to silence the gene

> > for autoimmunity (hashimoto's in

> > > my case). He recommended I take Phosphatidylcholine 385 mg,

> > softgels- 2 twice daily AND Betaine

> > > Free Base 1/2 teaspoon daily and monitor my TPO anti-bodies

> > frequently as it should be coming down

> > > while on the regimen for gene silencing. Both the Iodine and the

> > gene silencing supplements can be

> > > taken at the same time. I've ordered the supplements, so I will

> > keep you all posted.

> > >

> > > __________________________________________________

> > >

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I think the missing ingredients for you are cortisol (cortef) and DHEA. Your TSH is quite high.

Gracia

I HAD the worst depression of my life and panic attacks/anxiety primarily BEFORE I was takingthyroid hormone before I knew what was wrong. The symptoms and severity you experience soundlike undertreated hypothyroidism; although I would also suspect a severe magnesium deficiency.II take Levoxyl 125mcg. have tried Armour many times; I was on it again for the last 2 weeks andeven had a compounding pharmacy make me a custom blend. Others suggest that it would help theonly real symptom I have left and that is, exercise induced fatigue. The truth is, I just don'tfeel good when I take Armour. In the last two weeks of taking it I have lost so much hair that Ijust had to stop. I have never been this bald before, I just hope it all grows back....it usuallydoes.

..

No virus found in this outgoing message.

Checked by AVG Free Edition.

Version: 7.1.405 / Virus Database: 268.11.7/436 - Release Date: 9/1/2006

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I am on adrenal support (medorl) cortef was not strong enough. am on also on 2 1/2 gr....amour.. I started to take the magnesium the last couple of days and I have had diarrhia all day. I am having terrible stomach problems. Would you know why.

Ellen

I Re: Re: Phone consult with Flechas about Iodine loss- Gene silencing

I think the missing ingredients for you are cortisol (cortef) and DHEA. Your TSH is quite high.

Gracia

I HAD the worst depression of my life and panic attacks/anxiety primarily BEFORE I was takingthyroid hormone before I knew what was wrong. The symptoms and severity you experience soundlike undertreated hypothyroidism; although I would also suspect a severe magnesium deficiency.II take Levoxyl 125mcg. have tried Armour many times; I was on it again for the last 2 weeks andeven had a compounding pharmacy make me a custom blend. Others suggest that it would help theonly real symptom I have left and that is, exercise induced fatigue. The truth is, I just don'tfeel good when I take Armour. In the last two weeks of taking it I have lost so much hair that Ijust had to stop. I have never been this bald before, I just hope it all grows back....it usuallydoes.

..

No virus found in this outgoing message.Checked by AVG Free Edition.Version: 7.1.405 / Virus Database: 268.11.7/436 - Release Date: 9/1/2006

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Magnesium will do that. Can you cut back on it?

B.

I am on adrenal support (medorl) cortef was not strong enough. am on also on 2 1/2 gr....amour.. I started to take the magnesium the last couple of days and I have had diarrhia all day. I am having terrible stomach problems. Would you know why.

Ellen

Messages in this topic (19) Reply (via web post) | Start a new topic

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Thank you... that is what I am doing.

Ellen

Re: Re: Phone consult with Flechas about Iodine loss- Gene silencing

Magnesium will do that. Can you cut back on it?

B.

I am on adrenal support (medorl) cortef was not strong enough. am on also on 2 1/2 gr....amour.. I started to take the magnesium the last couple of days and I have had diarrhia all day. I am having terrible stomach problems. Would you know why.

Ellen

Messages in this topic (19) Reply (via web post) | Start a new topic

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>From: " Ellen " <maryellenmu@...>

>I am on adrenal support (medorl) cortef was not strong enough.

Strong enough for what?

You're on the equivalent of 30 mg of Cortef, were you on that much Cortef

before you switched to Medrol?

Cortef has a minerlocorticoid content to it which Medrol does not have.

This can be bad for the sodium / potassium balance and is the reason that

Cortef should be used before Medrol.

Do you take a good Vitamin C supplement, something the adrenals really need?

As for the magnesium questions, and others know a lot about that. You

should listen to their answers.

I have read that high cortisol levels deplete magnesium. That's common

knowldege. However, I've also read a few times that those with low cortisol

tend to retain a lot of magnesium. This makes sense to me, and my labs show

my blood levels of magnesium as being almost at the top of the normal range.

I don't feel well when I take magnesium, and I blame it on my low

adrenals. Yet, those doctors who treat adrenal fatigue, tend to suggest

magnesium, so maybe it is good for us.

Skipper

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Windows Live Spaces is here! It’s easy to create your own personal Web site.

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Milk of Magnesia is Magnesium and that is what is used for constipation. You probably need to ease into it.

B.

Re: Re: Phone consult with Flechas about Iodine loss- Gene silencing

Magnesium will do that. Can you cut back on it?

B.

I am on adrenal support (medorl) cortef was not strong enough. am on also on 2 1/2 gr....amour.. I started to take the magnesium the last couple of days and I have had diarrhia all day. I am having terrible stomach problems. Would you know why.

Ellen

Messages in this topic (19) Reply (via web post) | Start a new topic

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When I said adrenal support supplement I was talking about vitamins not

cortisol. The magnesium

sounds like too much too soon. Magnesium Glycinate capsules are very

absorbable. What type are

you taking and how much?

--- Ellen <maryellenmu@...> wrote:

> I am on adrenal support (medorl) cortef was not strong enough. am on also on

2 1/2

> gr....amour.. I started to take the magnesium the last couple of days and I

have had diarrhia

> all day. I am having terrible stomach problems. Would you know why.

> Ellen

> I Re: Re: Phone consult with Flechas about Iodine loss- Gene

silencing

>

>

>

>

> I think the missing ingredients for you are cortisol (cortef) and DHEA.

Your TSH is quite

> high.

> Gracia

>

> I HAD the worst depression of my life and panic attacks/anxiety primarily

BEFORE I was

> taking

> thyroid hormone before I knew what was wrong. The symptoms and severity

you experience sound

> like undertreated hypothyroidism; although I would also suspect a severe

magnesium

> deficiency.

>

> II take Levoxyl 125mcg. have tried Armour many times; I was on it again

for the last 2 weeks

> and

> even had a compounding pharmacy make me a custom blend. Others suggest

that it would help

> the

> only real symptom I have left and that is, exercise induced fatigue. The

truth is, I just

> don't

> feel good when I take Armour. In the last two weeks of taking it I have

lost so much hair

> that I

> just had to stop. I have never been this bald before, I just hope it all

grows back....it

> usually

> does.

>

>

>

> .

>

>

>

>

>

>

> ------------------------------------------------------------------------------

>

>

> No virus found in this outgoing message.

> Checked by AVG Free Edition.

> Version: 7.1.405 / Virus Database: 268.11.7/436 - Release Date: 9/1/2006

>

__________________________________________________

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Kal 400mg...I started cutting them in 1/2 today..

Re: Re: Phone consult with Flechas about Iodine loss- Gene silencing> > > > > I think the missing ingredients for you are cortisol (cortef) and DHEA. Your TSH is quite> high.> Gracia> > I HAD the worst depression of my life and panic attacks/anxiety primarily BEFORE I was> taking> thyroid hormone before I knew what was wrong. The symptoms and severity you experience sound> like undertreated hypothyroidism; although I would also suspect a severe magnesium> deficiency.> > II take Levoxyl 125mcg. have tried Armour many times; I was on it again for the last 2 weeks> and> even had a compounding pharmacy make me a custom blend. Others suggest that it would help> the> only real symptom I have left and that is, exercise induced fatigue. The truth is, I just> don't> feel good when I take Armour. In the last two weeks of taking it I have lost so much hair> that I> just had to stop. I have never been this bald before, I just hope it all grows back....it> usually> does. > > > > .> > > > > > > ----------------------------------------------------------> > > No virus found in this outgoing message.> Checked by AVG Free Edition.> Version: 7.1.405 / Virus Database: 268.11.7/436 - Release Date: 9/1/2006> __________________________________________________

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Kal is the brand name. What type of magnesium is it... mag cabonate, mag

citrate...etc?

--- Ellen <maryellenmu@...> wrote:

> Kal 400mg...I started cutting them in 1/2 today..

> Re: Re: Phone consult with Flechas about Iodine loss-

Gene silencing

> >

> >

> >

> >

> > I think the missing ingredients for you are cortisol (cortef) and DHEA.

Your TSH is quite

> > high.

> > Gracia

> >

> > I HAD the worst depression of my life and panic attacks/anxiety primarily

BEFORE I was

> > taking

> > thyroid hormone before I knew what was wrong. The symptoms and severity

you experience sound

> > like undertreated hypothyroidism; although I would also suspect a severe

magnesium

> > deficiency.

> >

> > II take Levoxyl 125mcg. have tried Armour many times; I was on it again

for the last 2 weeks

> > and

> > even had a compounding pharmacy make me a custom blend. Others suggest

that it would help

> > the

> > only real symptom I have left and that is, exercise induced fatigue. The

truth is, I just

> > don't

> > feel good when I take Armour. In the last two weeks of taking it I have

lost so much hair

> > that I

> > just had to stop. I have never been this bald before, I just hope it all

grows back....it

> > usually

> > does.

> >

> >

> >

> > .

> >

> >

> >

> >

> >

> >

> > ----------------------------------------------------------

> >

> >

> > No virus found in this outgoing message.

> > Checked by AVG Free Edition.

> > Version: 7.1.405 / Virus Database: 268.11.7/436 - Release Date: 9/1/2006

> >

>

> __________________________________________________

>

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