Check out Ethyl glucuronide - Wikipedia, the free encyclopedia

[Guest guest]

good pickup lb,looks like somone went in anonymously and changed the cutoffs and the text and eliminated the SAMHSA warning...very unsober...more will be

revealed...regards,r

nbsp; Your continued donations keep Wikipedia running! Ethyl glucuronide From Wikipedia, the free encyclopedia (Difference between revisions) Jump to: navigation, search Revision as of 01:56, 5 December 2006 (edit)66.81.57.137 (Talk)← Older edit Current revision (18:11, 5 December 2006) (edit)131.247.70.1 (Talk) Line 10: Line 10: While <1% of ethanol is converted to EtG, it is known that this metabolic pathway has great inter-individual variability in activity. While there are no studies to provide information specific for EtG production, other metabolites formed by the same liver isoforms as EtG demonstrate up to a 7-fold difference for one metabolite and a 30-fold difference for another. This said, two people with identical exposures to environmental and dietary unknown/unintentional sources of alcohol may produce very different levels. While <1% of ethanol is converted to EtG, it is known that this metabolic pathway has great inter-individual variability in activity. While there are no studies to provide information specific for EtG production, other metabolites formed by the same liver isoforms as EtG demonstrate up to a 7-fold difference for one metabolite and a

30-fold difference for another. This said, two people with identical exposures to environmental and dietary unknown/unintentional sources of alcohol may produce very different levels. - It’s also important to realize that EtG and EtS can be present in urine from non-beverage alcohol exposure. Following introduction of these tests numerous individuals came forward tenaciously claiming they were falsely accused of drinking because of positive EtG tests. Various products were tested on small numbers of individuals and it was found that ethanol containing mouthwash, sips of communion wine, alcohol free wine and beer, and OTC meds containing ethanol caused low positive EtG tests, up to 300-400ng/ml. A study using alcohol-based hand sanitizing gel (62% ethyl alcohol) indicated that inhalation, not skin absorption, is a major

absorption route for ethyl alcohol, producing very significant EtG levels. Lab experiments utilizing these hand gels have yielded EtG results in the 500-800ng/ml range on multiple occasions. + It’s also important to realize that EtG and EtS can be present in urine from non-beverage alcohol exposure. Following introduction of these tests numerous individuals came forward tenaciously claiming they were falsely accused of drinking because of positive EtG tests. Various products were tested on small numbers of individuals and it was found that ethanol containing mouthwash, sips of communion wine, alcohol free wine and beer, and OTC meds containing ethanol caused low positive EtG tests, up to 300-400ng/ml. A study using alcohol-based hand sanitizing gel (62% ethyl alcohol) indicated that inhalation, not skin absorption, is a major absorption route for ethyl alcohol, producing very significant EtG levels. Lab experiments utilizing these

hand gels have yielded EtG results in the 500-800ng/ml range on multiple occasions in one individual. In another study, however, inhallation of hand sanitizer did not cause a positive EtG test in any of the study participants. Certainly when an individual uses mouthwash or cold medication containing alcohol, this is not "incidental" exposure to alchol, rather intentional use of alcohol. The term "incidental" should be reserved for products that are not normally associated with the consumption of alcohol (e.g., hand sanitizer). - The question of where to set the cutoff for EtG to increase specificity regarding alcoholic beverage use and to decrease sensitivity to avoid detection of what has come to be called “incidental exposure” is frequently asked. Laboratories are currently offering cutoffs of

100, 250, 500 and 1000 ng/mL. These cutoffs have no scientific foundation in terms of identifying beverage alcohol consumption. Early European studies used the cutoff of 100ng/ml because that was the lowest level at which their instrumentation was technically reliable. There are no published studies on the effects of non-beverage alcohol (termed "incidental alcohol") on EtG levels. There are no large-scale studies that establish that EtG levels in non-drinkers will consistently fall below 100, 250, or even 500ng/ml. That said, it

is recommended that each agency select a cutoff that is appropriate based upon their flexibility (in dealing with investigations of false positive claims), sophistication in understanding the concepts, and severity of consequences from a positive test. Agencies must weigh the potential danger to the public against the possibility of a false accusation and the resulting consequences. As with any laboratory test, EtG is meant to be used as a tool in determining alcohol consumption. Other clinical factors should always be considered. + The question of where to set the cutoff for EtG to increase specificity regarding alcoholic beverage use and to decrease sensitivity to avoid detection of what has come to be called “incidental exposure” is frequently asked. Laboratories are currently offering cutoffs of 100, 250, 500 and 1000 ng/mL. Although these cutoffs used to have

no scientific foundation in terms of identifying beverage alcohol consumption, current research does support the use of 500 ng/mL. It is highly unlikely that individuals who have incidental consumption or exposure to alcohol (e.g., using mouthwash, cold medication, hand sanitizers, or other household or health products containing alcohol) will produce an EtG level greater than 500 ng/mL because the amount of alcohol in these products would be far less than the amount of alcohol found in one standard drink. Recent studies currently recommend consideration of 250 ng/mL as the cutoff levels for testing and the use of 500 ng/mL as

a guideline for intentional consumption of alcohol. It is recommended that each agency select a cutoff that is appropriate based upon their flexibility (in dealing with investigations of false positive claims), sophistication in understanding the concepts, and severity of consequences from a positive test. Agencies must weigh the potential danger to the public against the possibility of a false accusation and the resulting consequences. As with any laboratory test, EtG is meant to be used as a tool in determining alcohol consumption. Other clinical factors should always be considered. - - SAMHSA, the division of the U.S. Department of Health and Human Services that regulates workplace drug testing, issued an advisory on alcohol biomarkers, which includes the following 'black box warning' regarding

EtG: - - <blockquote> - Currently, the use of an EtG test in determining abstinence - lacks sufficient proven specificity for use as primary or sole - evidence that an individual prohibited from drinking, in a criminal justice or a regulatory compliance context, has truly been drinking. Legal or disciplinary action based solely on a positive EtG, or other test discussed in this Advisory, is inappropriate and scientifically unsupportable at this time. These tests should currently be considered as potential valuable clinical tools, but their use in forensic settings is

premature. - </blockquote> - - Many studies advise that EtG levels be “normalized” to a creatinine level of 100, which is expressed as “EtG100“. Particularly when levels are critically close to a cutoff level, such an adjustment may have crucial consequences. SAMHSA requires that a creatinine level be measured with all specimens tested for drugs. To normalize the level, use the following formula: “EtG100” = (EtG x 100) / Cr. - - ==External links== - {{ChemicalSources}} - - [[Category:Glycosides]] Current revision To meet Wikipedia's quality standards, this article or section may require cleanup.Please discuss this issue on the talk page, or replace this tag with a more specific message. This article has been tagged since August 2006lilibit007@... wrote: Ethyl glucuronide - Wikipedia, the free encyclopedia looks done dec 5 last modified..correct me if I am wrong

Cheap Talk? Check out Messenger's low PC-to-Phone call rates.

[Guest guest]

--- Hot diggity dawg! I now have 3 followers. I think I'll run for

President I could be a write in. I'd fix this shit in about 2 days.

Welcome to the cause!!!!

In Ethylglucuronide , crssemc@... wrote:

>

> Dear God is this going to end do we feel the need control

everything every human being does?? If I chose to ingest Mc's

everyday that would be my problem wouldn't it why so much hype with

the gov't. Are we really allowing them to decide the choices that one

would make. I am sorry but I see this sneaking up on us and we won't

even know it until all is said and done.

>

> Madison you have found a follower!!

>

> Re: Check out Ethyl glucuronide -

Wikipedia, the free encyclopedia

>

>

> --- http://www.stats.org/stories/food_addiction_redux_dec04_06.htm

>

> In Ethylglucuronide , " madisonxyz2000 "

> <madisonxyz2000@> wrote:

> >

> > ---http://www.stats.org/stories/make_addicts_dec18_2006.htm

> >

> >

> > In Ethylglucuronide , " lftbhnd007 " <lilibit007@>

> > wrote:

> > >

> > > why didnt have skippers back up to begin with..

> > > > Ethyl glucuronide - Wikipedia, the free

> encyclopedia

> > > what's up with this needed from a professional on the

subject ,Is

> > > this not from Skipper??just curious

> > > >

> > > >

> > > >

> > > >

> > > > __________________________________________________

> > > >

[Guest guest]

Madison the fist fix I am looking for is the EtG fix. DO you think you can do it?????

By the way who are your other 2 followers??

Re: Check out Ethyl glucuronide -

Wikipedia, the free encyclopedia

>

>

> --- http://www.stats.org/stories/food_addiction_redux_dec04_06.htm

>

> In Ethylglucuronide , "madisonxyz2000"

> <madisonxyz2000@> wrote:

> >

> > ---http://www.stats.org/stories/make_addicts_dec18_2006.htm

> >

> >

> > In Ethylglucuronide , "lftbhnd007" <lilibit007@>

> > wrote:

> > >

> > > why didnt have skippers back up to begin with..

> > > > Ethyl glucuronide - Wikipedia, the free

> encyclopedia

> > > what's up with this needed from a professional on the

subject ,Is

> > > this not from Skipper??just curious

> > > >

> > > >

> > > >

> > > >

> > > > __________________________________________________

> > > >

[Guest guest]

Number 4...you crack me up!

> > > > > Ethyl glucuronide - Wikipedia, the free

> > encyclopedia

> > > > what's up with this needed from a professional on the

> subject ,Is

> > > > this not from Skipper??just curious

> > > > >

> > > > >

> > > > >

> > > > >

> > > > > __________________________________________________

> > > > >

[Guest guest]

--- OH, I would fix this ETG shit PRONTO. I would issue an executive

order suspending all illegal search and seizure of body fluids. And

if any of those pansy asses in Congress tried to stop me, I would

send them off to see ole Ken Krap to learn humility.

I would issue an Executive Order that all drugs were to be made

legal. I would of course tax and regulate them so I could get alot

of tax money and I would be in charge of the drugs, of course.

And the " sobriety enforcers " who have needlessly ruined good peoples'

lives.....well, lets just say that they would have their comeuppance.

I would issue an executive order stating that they would have to

drink beer. Why this you ask? Well, ya'll know as well as I do that

the only people fanatical enough to be " sobriety enforcers " are

steppers. Therefore, the thing they are most scared of is devil

drink.

So for instilling all of this fear on you fine people, I would

instill the same fear into them. Of course, I would assist them in

their beer drinking (I'm not heartless you know)

Then, after I got this country straightened out, I would become ruler

of the world. Just think of the Dynasty I could create! Just as soon

as Robin and Lorie fill my 12-step preschool, there will be no

stopping me! I would bring the little darlins up right!

And who are my other two followers? Oh, a Supreme Ruler can't tell

everyting they know!!!!!!!!!

In Ethylglucuronide , crssemc@... wrote:

>

> Madison the fist fix I am looking for is the EtG fix. DO you think

you can do it?????

>

> By the way who are your other 2 followers??

>

>

> Re: Check out Ethyl glucuronide -

> Wikipedia, the free encyclopedia

> >

> >

> > --- http://www.stats.org/stories/food_addiction_redux_dec04_06.htm

> >

> > In Ethylglucuronide , " madisonxyz2000 "

> > <madisonxyz2000@> wrote:

> > >

> > > ---http://www.stats.org/stories/make_addicts_dec18_2006.htm

> > >

> > >

> > > In Ethylglucuronide , " lftbhnd007 " <lilibit007@>

> > > wrote:

> > > >

> > > > why didnt have skippers back up to begin with..

> > > > > Ethyl glucuronide - Wikipedia, the free

> > encyclopedia

> > > > what's up with this needed from a professional on the

> subject ,Is

> > > > this not from Skipper??just curious

> > > > >

> > > > >

> > > > >

> > > > >

> > > > > __________________________________________________

> > > > >

[Guest guest]

--- Holy Doorknob!!!!! 4 followers!!!! This is a mandate. I know I

will run for President now. Only one problem. Have ya'll noticed

that little media darlin Barak Obama? He could be a challange to

beat in an election. Maybe he will consider being my Vice

President. Did ya'll know that he smokes cigarettes? Honest to God,

I shit you not. I hope he doesn't quit. I love rebels.

In Ethylglucuronide , " nilesclay " <nilesclay@...>

wrote:

>

> Number 4...you crack me up!

>

>

>

> > > > > > Ethyl glucuronide - Wikipedia, the free

> > > encyclopedia

> > > > > what's up with this needed from a professional on the

> > subject ,Is

> > > > > this not from Skipper??just curious

> > > > > >

> > > > > >

> > > > > >

> > > > > >

> > > > > > __________________________________________________

> > > > > >

[Guest guest]

So what role does Smarty play in all of this? Are you just gonna abandon him once you get to be Supreme Being? Let's not forget who got you there! madisonxyz2000 <madisonxyz2000@...> wrote: --- OH, I would fix this ETG shit PRONTO. I would issue an executive order suspending all illegal search and seizure of body fluids. And if any of those pansy asses in Congress tried to stop me, I would send them off to see ole Ken Krap to learn humility.I would

issue an Executive Order that all drugs were to be made legal. I would of course tax and regulate them so I could get alot of tax money and I would be in charge of the drugs, of course.And the "sobriety enforcers" who have needlessly ruined good peoples' lives.....well, lets just say that they would have their comeuppance.I would issue an executive order stating that they would have to drink beer. Why this you ask? Well, ya'll know as well as I do that the only people fanatical enough to be "sobriety enforcers" are steppers. Therefore, the thing they are most scared of is devil drink.So for instilling all of this fear on you fine people, I would instill the same fear into them. Of course, I would assist them in their beer drinking (I'm not heartless you know)Then, after I got this country straightened out, I would become ruler of the world. Just think of the Dynasty I could create! Just as soon as Robin

and Lorie fill my 12-step preschool, there will be no stopping me! I would bring the little darlins up right!And who are my other two followers? Oh, a Supreme Ruler can't tell everyting they know!!!!!!!!!In Ethylglucuronide , crssemc@... wrote:>> Madison the fist fix I am looking for is the EtG fix. DO you think you can do it?????> > By the way who are your other 2 followers?? > > > Re: Check out Ethyl glucuronide - > Wikipedia, the free encyclopedia> > > > > > --- http://www.stats.org/stories/food_addiction_redux_dec04_06.htm> > > > In Ethylglucuronide , "madisonxyz2000" > > <madisonxyz2000@> wrote:> > >> > > ---http://www.stats.org/stories/make_addicts_dec18_2006.htm> > > > > > > > > In Ethylglucuronide , "lftbhnd007" <lilibit007@> > > > wrote:> > > >> > > > why didnt

have skippers back up to begin with..> > > > > Ethyl glucuronide - Wikipedia, the free > > encyclopedia

> > > > what's up with this needed from a professional on the > subject ,Is > > > > this not from Skipper??just curious> > > > > > > > > > > > > > > > > > > > > > > > > __________________________________________________> > > > >

[Guest guest]

Did ya'll know that he smokes cigarettes? THANKS for that tidbit. Didn't he admit to snorting coke back in the day? Big woop-ti-do. But smoking cigs in '06...Geez, if I find out he has a hawg, he's got my vote in the bag! madisonxyz2000 <madisonxyz2000@...> wrote: --- Holy Doorknob!!!!! 4 followers!!!! This is a mandate. I know I will run for President now. Only one

problem. Have ya'll noticed that little media darlin Barak Obama? He could be a challange to beat in an election. Maybe he will consider being my Vice President. Did ya'll know that he smokes cigarettes? Honest to God, I shit you not. I hope he doesn't quit. I love rebels. In Ethylglucuronide , "nilesclay" <nilesclay@...> wrote:>> Number 4...you crack me up!> > > > > > > > > Ethyl glucuronide - Wikipedia, the free > > > encyclopedia > > > > > what's up with this needed from a professional on the > > subject ,Is > > > > > this not from Skipper??just curious> > > > > > > > > > > > > > > > > > > > > > > > > > > > > > __________________________________________________> > > > > >

[Guest guest]

Ethyl glucuronide - Wikipedia, the free encyclopedia DOES EVERYONE WANT TO START A NEW PAGE ON THIS..WE HAVE THE DOCS FROM SAMPSA AND OTHER RESEARCH STUFF. AND I BELEIVE THAT WE CAN POST COMMENTARY ON IT.. I WOULD DO IT BUT I AM STILL REAL BUSEY FIGHTING MY CASE AND I DONT KNOW HOW TO TRANSFER FILES ECTSee what's free at AOL.com.