%CDT federally approved blood test best backup biomarker .

[Guest guest]

Article Tools Printer-Friendly Email This Download This View Online Email This Close Your

Name: Your Email: Recipient's Email: Separate multiple email addresses with commas (Limit is 10). Subject: Optional Message: Download This Close MEDLINE Bookends Endnote Papyrus Procite Refman Quickdoc Format. Validity of carbohydrate-deficient transferrin (%CDT), gamma-glutamyltransferase (gamma-GT) and mean corpuscular erythrocyte volume (MCV) as biomarkers for chronic alcohol abuse: a study in patients with alcohol dependence and liver disorders of non-alcoholic and alcoholic origin. Information from Industry TOPAMAX® (topiramate) Tablets Review findings: Important Safety

Information Full Prescribing Information Medscape Newsletters Sign Up To ReceiveMedscape Best Evidence Key journal articles ranked for newsworthiness and clinical relevance in each specialty, linked to Medline abstracts. Addiction. 2005; 100(10):1477-86 (ISSN: 0965-2140) Hock B; Schwarz M; Domke I; Grunert VP; Wuertemberger M; Schiemann U; Horster S; Limmer C; Stecker G; Soyka MPsychiatric Clinic of Ludwig-Maximilian-University, Munich, Germany.

bettina.hock@... AIM: To test the clinical performance of carbohydrate-deficient transferrin (%CDT), gamma-glutamyltransferase (gamma-GT) and mean corpuscular erythrocyte volume (MCV) as biomarkers for alcoholism with a special focus on patients suffering from liver diseases. DESIGN: Well-characterized collectives of alcohol-dependent patients with current consumption (ALC patients, n = 101), and relevant control groups (115 social drinkers, 46 patients with unspecifically increased gamma-GT, 51 hepatitis patients and 20/31 patients with non-alcohol/alcohol-dependent liver cirrhosis) were included into the study. The Positive Alcohol Use Disorders Test (AUDIT) score, International Classification of Diseases version 10 (ICD-10)/Diagnostic and Statistical Manual version IV (DSM-IV) criteria and blood drawn within 4 days of last drinking were inclusion criteria for subjects with regular heavy drinking.

%CDT was determined using an automated assay which recently had been completely modified. FINDINGS: Median AUDIT scores of patients without/with regular heavy drinking were 1-3/27. The following medians/95th percentiles were obtained for %CDT: social drinkers 2.2/3.0, patients with unspecifically increased gamma-GT 2.1/3.0, hepatitis 2.0/4.4, non-alcohol-dependent liver cirrhosis 2.4/4.8, alcohol-dependent liver cirrhosis 3.0/5.9, ALC patients 3.9/14.9. Differences between patients without and with alcohol abuse were highly significant (P < 0.001). No differences in CDT values were found between males and females. There was no correlation between %CDT values, gamma-GT, MCV and the amount of alcohol consumed in ALC patients; 3.0%CDT (95th percentile social drinkers) is proposed as cut-off for the test used (Tina-quant %CDT 2nd-generation). At this cut-off, the sensitivity for ALC patients was 73.3%, whereas gamma-GT/MCV had a sensitivity of 71.3%/64.4%. Multivariate

analysis performed at 95% specificity resulted in an improvement of the sensitivity by combining %CDT with gamma-GT (83.2%). A further enhancement of the sensitivity to 88.1% was obtained by combination of %CDT, gamma-GT and MCV. The diagnostic specificity of %CDT calculated at the cut-off of 3% was 93.5% in patients with unspecifically increased gamma-GT, 88.2% in hepatitis patients and 70.0% in patients with non-alcohol-dependent liver cirrhosis. %CDT was more specific in these patient collectives than MCV, and especially more than gamma-GT (specificity in hepatitis 52.9%, and 35.0% in non-alcohol-dependent liver cirrhosis). CONCLUSION: %CDT is of high diagnostic value to support diagnosis of alcohol-use disorders. The specificity of this marker in patient groups with liver disorders is superior to the biomarkers gamma-GT and MCV.mslizrn@... wrote: Thank you I really needed to hear encouraging words, I don't know about the %CDT can you tell me more?--------- Re: lie detector> Date: Sun, 30 Dec 2007 00:05:03 +0000> > You didn't get the meaning of that at all....the> conection was how everything is done from fear...and> it is not only the boards. There was no connection to> Lorie as a terrorist....how you came up with that is> just beyond me! Lorie never did the lie detector> test....I did...it cost me lots of money and was> meaningless, except to the WSJ reporter.> --- danramo <danramoaol> wrote:> > > Yikes!!Lorie'Now you are a terrorist!! Maybe your> > attorney could > > arrange another lie detector test. It will not be> > validated by your > > monitoring program but would give you moral high> >

ground.Dr. Dan> > > > > > __________________________________________________________> Never miss a thing. Make your home page. > http://www./r/hs> > > From: robin murray <remurraymd@...>Ethylglucuronide Subject: liz do what you can do then relax...Date: Sun, 30 Dec 2007 12:08:57 +0000 honestly liz they do not care if you are lying.the more you give them problems the more you will be deemed "non-compliant" and in "relapse mode". the boards just have these draconian policies they have use on everybody...you are right EtG will fall it is just a matter of time.in the meantime odds are if you are careful and use the info on this site you will not test false positive again.just do what you can do...no

etoh exposure no ingestion probiotics low gi diet no otc or rx upregulators liver metabolizing drugs...pretty simple really. i would consider a %CDT every month and graph them so if you get a positive you can refute with CDT federally approved biomarker.do daily calls and meetings recovery work md appts precisely as directed keep records. then relax..the odds are overwhelmingly in your favor...regards,r mslizrncomcast (DOT) net wrote: I did the lie detector as well, passed of course and it was meaningless to the BRN here as well. The fear is the thing that only we can comprehend. I literally wake up at night with my heart pounding at the thought of starting testing again. I broke down and cried today for over

an hour just at the frustration and fear. I keep telling myself that things could be worse, my family is well, I have a home etc., but the thought of another positive EtG and the fact that nothing I do or don't do matters is so overwhelming at times. I just need to vent and feel sorry for myself now and again!!-------------- Original message ----------------------From: N <nautiques5 >> You didn't get the meaning of that at all....the> conection was how everything is done from fear...and> it is not only the boards. There was no connection to> Lorie as a terrorist....how you came up with that is> just beyond me! Lorie never did the lie detector> test....I did...it cost me lots of money and was> meaningless, except to the WSJ reporter.> --- danramo <danramoaol>

wrote:> > > Yikes!!Lorie'Now you are a terrorist!! Maybe your> > attorney could > > arrange another lie detector test. It will not be> > validated by your > > monitoring program but would give you moral high> > ground.Dr. Dan> > > > > > > > > __________________________________________________________> ____> Never miss a thing. Make your home page. > http://www./r/hsFrom: N <nautiques5 >Ethylglucuronide Subject: Re: lie detectorDate: Sun, 30 Dec 2007 00:05:03 +0000 You didn't get the meaning of that at all....theconection was how everything is done from fear...andit is not

only the boards. There was no connection toLorie as a terrorist....how you came up with that isjust beyond me! Lorie never did the lie detectortest....I did...it cost me lots of money and wasmeaningless, except to the WSJ reporter.--- danramo <danramoaol> wrote:> Yikes!!Lorie'Now you are a terrorist!! Maybe your> attorney could > arrange another lie detector test. It will not be> validated by your > monitoring program but would give you moral high> ground.Dr. Dan> > __________________________________________________________Never miss a thing. Make your home page. http://www./r/hs