Guest guest Posted January 3, 2000 Report Share Posted January 3, 2000 In a message dated 1/3/00 8:45:57 PM Eastern Standard Time, lsieverl@... writes: << There is a drug called Gabapentin. I don't know anything about it, except that it is an anti-seizure drug. >> Carol, that's Neurontin. Gail Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 3, 2000 Report Share Posted January 3, 2000 is Gabapentin--the same as neurontin Sieverling wrote: > Be careful about assuming that GABA can replace Klonopin. Klonopin > is a benzodiazepine that down-regulates the NMDA receptor. As > discussed earlier, Neurontin is a drug that up-regulates the GABA > receptor. They are aiming for the same goal - balancing GABA and NMDA > - but from opposite directions. It depends on what you mean by > GABA. There is a drug called Gabapentin. I don't know anything about > it, except that it is an anti-seizure drug. There is an amino acid > called Gamma-aminobutyric acid that is known as GABA. In my recent > amino acid analysis from Great Smoky Labs, my GABA is way off, and in > the comments, they say " urinary GABA is considered unrelated to > Central Nervous System levels where GABA is a neurotransmitter " . I'm > not sure, but it sounds to me like one is a neurotransmitter and one > is an amino acid. Even if they are the same thing, I'm not sure that > supplementing the amino acid can affect the neurotransmitter level. I > think Cheney would have mentioned it or tried it, since he places so > much importance on Klonopin, or for some patients Neurontin. Take > care. Carol Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 3, 2000 Report Share Posted January 3, 2000 I take both klonopin and neurontin -- I have been doing ok but it could be better GAILRONDA@... wrote: > From: GAILRONDA@... > > In a message dated 1/3/00 8:45:57 PM Eastern Standard Time, > lsieverl@... writes: > > << There is a drug called Gabapentin. I don't know anything about it, except > that it is an anti-seizure drug. >> > Carol, that's Neurontin. > Gail > > > This list is intended for patients to share personal experiences with each other, not to give medical advice. If you are interested in any treatment discussed here, please consult your doctor. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 4, 2000 Report Share Posted January 4, 2000 Carol et al., I can't comment on the virtues or vices of using GABA as opposed to Klonopin or Neurontin, as I don't know enuf, but in your post you mentioned " Gabapentin " which you said you didn't know anything about. You do! It's the chemical/generic name for " Neurontin. " You're so lovely, so helpful, work so hard, so intelligent that how dare I know something you don't I said. Will it be seen as an effort at competition? Please, not to do such, anyone. Carol has given us so much more info and reasoning about it than I ever could. But I did want to let her and others who might not have been aware, though I'm sure many are, about the fact that gabapentin is nothing more or less than Neurontin. Judith Wisdom On Mon, 3 Jan 2000 19:46:37 -0600 " Sieverling " <lsieverl@...> writes: > Be careful about assuming that GABA can replace Klonopin. Klonopin > is a benzodiazepine that down-regulates the NMDA receptor. As > discussed earlier, Neurontin is a drug that up-regulates the GABA > receptor. They are aiming for the same goal - balancing GABA and > NMDA - but from opposite directions. > > It depends on what you mean by GABA. > > There is a drug called Gabapentin. I don't know anything about it, > except that it is an anti-seizure drug. > > There is an amino acid called Gamma-aminobutyric acid that is known > as GABA. In my recent amino acid analysis from Great Smoky Labs, my > GABA is way off, and in the comments, they say " urinary GABA is > considered unrelated to Central Nervous System levels where GABA is > a neurotransmitter " . > > I'm not sure, but it sounds to me like one is a neurotransmitter and > one is an amino acid. Even if they are the same thing, I'm not sure > that supplementing the amino acid can affect the neurotransmitter > level. I think Cheney would have mentioned it or tried it, since he > places so much importance on Klonopin, or for some patients > Neurontin. > > Take care. Carol Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 4, 2000 Report Share Posted January 4, 2000 I'm not sure, but it sounds to me like one is a neurotransmitter and one is an amino acid. GABA the amino acid is a neurotransmitter. They are one and the same thing. Even if they are the same thing, I'm not sure that supplementing the amino acid can affect the neurotransmitter level. Supplementing with the amino acid GABA will probably not affect brain levels of GABA that much because GABA doesn't cross the blood-brain barrier very well. GABA drugs like Gabapentin/Neurontin does. Patti -- Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 11, 2007 Report Share Posted January 11, 2007 Mandimart stocks GABA. Vicky Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 11, 2007 Report Share Posted January 11, 2007 REF not being avilable in the UK - I used not to keep it at Mandi Mart for that reasion but found other UK sites with it on and loads on Ebay so Mandi Mart keeps it now. Its just plain GABA as used in the Yasko protocol. http://www.mandimart.com/gabapowder.htm Last ages, we like GABA, using 3 grams per day now Mandi x Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 11, 2007 Report Share Posted January 11, 2007 You at present only stock Gaba powder, do you think that you might stock capsules at some point? >>>Doubt it - but I do have some here which I am going to put in the supp swop at the weekend if I can get myself organised. I keep stuff that I can offer for less than other suppliers or that you can;t get easily or on-line Mandi x Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 11, 2007 Report Share Posted January 11, 2007 Hi Emma We have been using Gabba for nearly a year. We use Kirkman Gabba Plus and we give 2 a day (300mg). Yes you are correct about it not being licenced in the UK and so we have to get it from the States. Very soon after using it we saw a calmer boy. He still has some flare ups but less. (Louis is now 7 and weighs about 60lbs.) When we have run out of it, (which is very easy to do as it comes from the USA,) he certainly seems more aggitated. Hope that helps Kay. GABA Hi everyone I just wondered if any of you have had experience withusing GABA and what your experiences have been good or bad of it? Alsoi know that it is not available in this country so wonder if anyonecould point me in the right direction to obtain some. Thankyou for readingemmax Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 11, 2007 Report Share Posted January 11, 2007 Hi Emma, I am an American mom living in Germany. My son is 7 and has Aspergers. You can get GABA from Cenaverde in the netherlands. We have given my son 5-Htp as recommended from DAN doctor in US. My husband and I have tried GABA ourselves to see the effect and it is very calming. Wonderful for oncoming panice attack. I have still not tried it on my son. > > Hi Emma > > We have been using Gabba for nearly a year. We use Kirkman Gabba Plus and we give 2 a day (300mg). Yes you are correct about it not being licenced in the UK and so we have to get it from the States. > Very soon after using it we saw a calmer boy. He still has some flare ups but less. (Louis is now 7 and weighs about 60lbs.) > When we have run out of it, (which is very easy to do as it comes from the USA,) he certainly seems more aggitated. > > Hope that helps > Kay. > GABA > > > Hi everyone I just wondered if any of you have had experience with > using GABA and what your experiences have been good or bad of it? Also > i know that it is not available in this country so wonder if anyone > could point me in the right direction to obtain some. Thankyou for reading > emmax > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 11, 2007 Report Share Posted January 11, 2007 Mandi You at present only stock Gaba powder, do you think that you might stock capsules at some point? Regards Kay. Re: Re: GABA Mandimart stocks GABA. Vicky Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 11, 2007 Report Share Posted January 11, 2007 Hi Kay, Just to say we use GABA with Tom. when we first gave it to him I misunderstood the dose had advised and gave him loads too much. We give him 3 x tspns a day. The result was AMAZING! A big wow for us! Particularly in language but an all round improvement in mood, awareness etc. needless to say we still give the big dose. Sara Re: Re: GABA Mandi You at present only stock Gaba powder, do you think that you might stock capsules at some point? Regards Kay. Re: Re: GABA Mandimart stocks GABA. Vicky -- No virus found in this incoming message. Checked by AVG Free Edition. Version: 7.5.432 / Virus Database: 268.16.9/622 - Release Date: 10/01/2007 14:52 -- No virus found in this outgoing message. Checked by AVG Free Edition. Version: 7.5.432 / Virus Database: 268.16.9/622 - Release Date: 10/01/2007 14:52 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 12, 2007 Report Share Posted January 12, 2007 GABA was also a huge WOW here. We began it about a year ago -- it was the first supplement we used when we switched over to the Yasko protocol. Our daughter became calmer and within a week and a half she began singing parts of songs non-verbally. She now has a whole reperatoire of songs she sings nonverbally and even does variations on them -- everthing entirely in tune. Here is piece of new research on the effect of GABA supplementation on relaxation, brain alpha waves, and the immune system. Hugs, Theresa Biofactors. 2006;26(3):201-8. Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans. Abdou AM, Higashiguchi S, Horie K, Kim M, Hatta H, Yokogoshi H. Department of Research and Development, Pharma Foods International Co. Ltd., Kyoto, Japan. adham@... The effect of orally administrated gamma-aminobutyric acid (GABA) on relaxation and immunity during stress has been investigated in humans. Two studies were conducted. The first evaluated the effect of GABA intake by 13 subjects on their brain waves. Electroencephalograms (EEG) were obtained after 3 tests on each volunteer as follows: intake only water, GABA, or L-theanine. After 60 minutes of administration, GABA significantly increases alpha waves and decreases beta waves compared to water or L-theanine. These findings denote that GABA not only induces relaxation but also reduces anxiety. The second study was conducted to see the role of relaxant and anxiolytic effects of GABA intake on immunity in stressed volunteers. Eight acrophobic subjects were divided into 2 groups (placebo and GABA). All subjects were crossing a suspended bridge as a stressful stimulus. Immunoglobulin A (IgA) levels in their saliva were monitored during bridge crossing. Placebo group showed marked decrease of their IgA levels, while GABA group showed significantly higher levels. In conclusion, GABA could work effectively as a natural relaxant and its effects could be seen within 1 hour of its administration to induce relaxation and diminish anxiety. Moreover, GABA administration could enhance immunity under stress conditions.PMID: 16971751 [PubMed - in process] > > Hi everyone I just wondered if any of you have had experience with > using GABA and what your experiences have been good or bad of it? Also > i know that it is not available in this country so wonder if anyone > could point me in the right direction to obtain some. Thankyou for reading > emmax > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 12, 2007 Report Share Posted January 12, 2007 WOW!! Have just started using GABA this week with Sam as his anxiety is bad and increasing at the moment, I will report back how it goes, I was being really conservative and giving him 1/4 teaspoon as it says, maybe increase dose?? Sam is also majorly active hyperactive is the word I am looking for!!Di x any advice appreciated as always >>You increase it slowly - Per theresa which is what we did, started with 1/4 teasppon at night, then twice per day then upped it by 1/4 teaspoon per day - I use heaped x 2 of the scoop prrovided for each dose now - maybe more than 3 grams, I think its helping tio calm him but he is much calmer anyways now, more so since we started the Zeolites again on Monday Mandi x Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 12, 2007 Report Share Posted January 12, 2007 > > REF not being avilable in the UK - I used not to keep it at Mandi Mart for > that reasion but found other UK sites with it on and loads on Ebay so Mandi > Mart keeps it now. Its just plain GABA as used in the Yasko protocol. > > _http://www.mandimart.com/gabapowder.htm_ > (http://www.mandimart.com/gabapowder.htm) > > Last ages, we like GABA, using 3 grams per day now WOW!! Have just started using GABA this week with Sam as his anxiety is bad and increasing at the moment, I will report back how it goes, I was being really conservative and giving him 1/4 teaspoon as it says, maybe increase dose?? Sam is also majorly active hyperactive is the word I am looking for!! Di x any advice appreciated as always > > Mandi x > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 13, 2007 Report Share Posted January 13, 2007 How high can we go then? I have just been giving quarter spoon once a day. TIA Vicky Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 13, 2007 Report Share Posted January 13, 2007 Thanks Theresa, we had nice and calm and then went to grumpy so I will switch to night time then, wasn't sure what to do. Vicky Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 13, 2007 Report Share Posted January 13, 2007 Hey Vicky, In the Yasko protocol it is recommended that you start very low, and titre up slowly to the point where you get mushy, and then pull back abit. We have never done this, but just started with 1/4 capsule and worked our way up to 1 capsule. Most kids do great right away on ity, some kids get a little grumpy for a few weeks and then it seems to go away. We started with it during the day, Lulu got grumpy, so we switched to doing it at night, which worked perfectly for her, so we continued with that. Hugs, Theresa > > How high can we go then? > I have just been giving quarter spoon once a day. > TIA > Vicky > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 13, 2007 Report Share Posted January 13, 2007 > > > > How high can we go then? > > I have just been giving quarter spoon once a day. > > TIA > > Vicky > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 14, 2007 Report Share Posted January 14, 2007 Hey Di, Too relaxed, spaced out, low energy -- like Sleepy in Snow White and the Seven Dwarves or something. Hugs, Theresa > > > > > > How high can we go then? > > > I have just been giving quarter spoon once a day. > > > TIA > > > Vicky > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 14, 2007 Report Share Posted January 14, 2007 > > > > > > > > How high can we go then? > > > > I have just been giving quarter spoon once a day. > > > > TIA > > > > Vicky > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 14, 2007 Report Share Posted January 14, 2007 I just wanted to add my two penneth worth. I never knew what ‘mushy’ meant either but Tom has always had a tendency to low energy and being spaced out. We concentrate our efforts on exciting him and bringing him to life. the reason I mention this is because when we gave Tom the ridiculously high dose of GABA we saw brilliant results so I’m not sure about the ‘mushy’ theory. If I’d understood what the word meant I might not have given him any. SARA Re: GABA > > > > > > > > How high can we go then? > > > > I have just been giving quarter spoon once a day. > > > > TIA > > > > Vicky > > > > > > > > > > -- No virus found in this incoming message. Checked by AVG Free Edition. Version: 7.5.432 / Virus Database: 268.16.10/625 - Release Date: 13/01/2007 17:40 -- No virus found in this outgoing message. Checked by AVG Free Edition. Version: 7.5.432 / Virus Database: 268.16.10/625 - Release Date: 13/01/2007 17:40 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 15, 2007 Report Share Posted January 15, 2007 Hey Sara, Although it may seem paradoxical, that makes a lot of sense to me. Mushy comes when you have gone too far in the dose, and maybe that's for kids who are hyperactive/hyperexcitable. GABA made Lulu able to focus better on things, it increased her attention andcognitively she began to wake up. In the peripheral system (meaning not in the central nervous system) GABA evidently also works on the endocrine system. There is a recent article out concerning this -- and they evidently are just learning more about it (but they've ony really known about GABA for a while now -- it's pretty new, the science on GABA). What is interesting, is that GABA is evidently active peripherally (meanig it doesn't have to cross the blood-brain barrier) in several areas that are becoming increasingly recognized to be problem areas for autism -- including the pancreas/ blood sugar regulation (Lulu had problems with that), pituitary/sex hormones (looka the Gieir stuff on hormones, and then look at the fact that progesterone is becoming THE big thing used for myelin repair in everything from spinal cord innjury to traumatic brain injury to Multiple Sclerosis -- Lulu has hypomyelination), and adrenal glands/adrenal issues (so many kids have problems with this). So GABA does a lot more than we thinnk it does. See the abstract below. Many hugs, Theresa Auton Neurosci. 2006 Jan 30;124(1-2):1-8. Epub 2005 Dec 7. The peripheral GABAergic system as a target in endocrine disorders. Gladkevich A, Korf J, Hakobyan VP, Melkonyan KV. Department of Psychiatry, University Medical Center Groningen, University Groningen, Hanzeplein 1, PO Box 30.001, 9700 RB Groningen, The Netherlands. a.v.gladkevich@... In addition to its well-recognized function as a cerebral inhibitory transmitter, less well established is the role of GABA in peripheral nervous and endocrine systems. We summarize current evidence that GABA serves as a neurotransmitter or neuromodulator in the autonomic nervous system and as a hormone or trophic factor in non-neuronal peripheral tissue as well. GABA is widely distributed in endocrine tissues including the pituitary, pancreas, adrenal glands, uterus, ovaries, placenta and testis. Moreover, GABA is involved in the pathophysiology of endocrine disorders such as diabetes mellitus, diseases of adrenal glands and reproductive tracts. Current literature indicates that the peripheral GABA system in the autonomic nervous system, endocrine and immune systems is as yet nearly an unexplored target for diagnosis and drug treatment. Publication Types: • Review PMID: 16338174 [PubMed - indexed for MEDLINE] > > > > > > > > > > How high can we go then? > > > > > I have just been giving quarter spoon once a day. > > > > > TIA > > > > > Vicky > > > > > > > > > > > > > > > > > > > -- > No virus found in this incoming message. > Checked by AVG Free Edition. > Version: 7.5.432 / Virus Database: 268.16.10/625 - Release Date: 13/01/2007 > 17:40 > > > > -- > No virus found in this outgoing message. > Checked by AVG Free Edition. > Version: 7.5.432 / Virus Database: 268.16.10/625 - Release Date: 13/01/2007 > 17:40 > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 15, 2007 Report Share Posted January 15, 2007 We also had a noticeable increase in expressive language with GABA, didn't notice that it increased energy. Re: GABA Hey Sara,Although it may seem paradoxical, that makes a lot of sense to me. Mushy comes when you have gone too far in the dose, and maybe that's for kids who are hyperactive/hyperexcitable. GABA made Lulu able to focus better on things, it increased her attention andcognitively she began to wake up. In the peripheral system (meaning not in the central nervous system) GABA evidently also works on the endocrine system. There is a recent article out concerning this -- and they evidently are just learning more about it (but they've ony really known about GABA for a while now -- it's pretty new, the science on GABA). What is interesting, is that GABA is evidently active peripherally (meanig it doesn't have to cross the blood-brain barrier) in several areas that are becoming increasingly recognized to be problem areas for autism -- including the pancreas/ blood sugar regulation (Lulu had problems with that), pituitary/sex hormones (looka the Gieir stuff on hormones, and then look at the fact that progesterone is becoming THE big thing used for myelin repair in everything from spinal cord innjury to traumatic brain injury to Multiple Sclerosis -- Lulu has hypomyelination), and adrenal glands/adrenal issues (so many kids have problems with this). So GABA does a lot more than we thinnk it does. See the abstract below.Many hugs,TheresaAuton Neurosci. 2006 Jan 30;124(1-2):1-8. Epub 2005 Dec 7. The peripheral GABAergic system as a target in endocrine disorders. Gladkevich A, Korf J, Hakobyan VP, Melkonyan KV. Department of Psychiatry, University Medical Center Groningen, University Groningen, Hanzeplein 1, PO Box 30.001, 9700 RB Groningen, The Netherlands. a.v.gladkevichpsy (DOT) umcg.nl In addition to its well-recognized function as a cerebral inhibitory transmitter, less well established is the role of GABA in peripheral nervous and endocrine systems. We summarize current evidence that GABA serves as a neurotransmitter or neuromodulator in the autonomic nervous system and as a hormone or trophic factor in non-neuronal peripheral tissue as well. GABA is widely distributed in endocrine tissues including the pituitary, pancreas, adrenal glands, uterus, ovaries, placenta and testis. Moreover, GABA is involved in the pathophysiology of endocrine disorders such as diabetes mellitus, diseases of adrenal glands and reproductive tracts. Current literature indicates that the peripheral GABA system in the autonomic nervous system, endocrine and immune systems is as yet nearly an unexplored target for diagnosis and drug treatment. Publication Types: • Review PMID: 16338174 [PubMed - indexed for MEDLINE] > > > > >> > > > > How high can we go then?> > > > > I have just been giving quarter spoon once a day.> > > > > TIA> > > > > Vicky> > > > >> > > >> > >> >> > > > > --> No virus found in this incoming message.> Checked by AVG Free Edition.> Version: 7.5.432 / Virus Database: 268.16.10/625 - Release Date: 13/01/2007> 17:40> > > > -- > No virus found in this outgoing message.> Checked by AVG Free Edition.> Version: 7.5.432 / Virus Database: 268.16.10/625 - Release Date: 13/01/2007> 17:40> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 15, 2007 Report Share Posted January 15, 2007 Theresa, You're marvelous! I could hardly fall asleep last night coming up with my own lame-brained theories about why the GABA seemed to be working opposite of what I'd read for Sara's son. I'm going to read these carefully when I have more time. Thank you. Anita > > > > > > > > > > > > How high can we go then? > > > > > > I have just been giving quarter spoon once a day. > > > > > > TIA > > > > > > Vicky > > > > > > > > > > > > > > > > > > > > > > > > > > > > -- > > No virus found in this incoming message. > > Checked by AVG Free Edition. > > Version: 7.5.432 / Virus Database: 268.16.10/625 - Release Date: > 13/01/2007 > > 17:40 > > > > > > > > -- > > No virus found in this outgoing message. > > Checked by AVG Free Edition. > > Version: 7.5.432 / Virus Database: 268.16.10/625 - Release Date: > 13/01/2007 > > 17:40 > > > Quote Link to comment Share on other sites More sharing options...
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