Virgin Coconut and Cancer ( my research short list)

[Guest guest]

Virgin Coconut and Cancer

Research by: LD Wedewer PhD

Cancer research, studies, and reviews (short list)

There are some things in this world that we all dread to hear. Something no

one hopes to experience. And a physician confirming that you are afflicted

with fatal cancer is definitely one of it! But thanks to virgin coconut

oil, there is after all a way out of this seemingly hopeless situation.

It is a sad truth that so many people are afflicted with this fatal

disease. Cancer ranks second in the leading cause of death statistics of the

United States. It is said that approximately one million people acquire cancer

each year.

There are various types of cancer but one characteristic that all cancer

diseases share is the rapid growth of abnormal cells in the body. Normal

cells follow a regular cycle of growth, division and death. In the early stage

of life, there is rapid cellular activity. But cells of a healthy adult

person only divide to replace dying cells and to heal damage caused by

injuries.

Cancer cells keep on growing and dividing and create abnormal cells. Cancer

cells may spread and cause problems to other parts of the body. This is

triggered by a damage to DNA. Unlike normal cells, cancer cells cannot

repair damaged DNA. Damaged DNA can be acquired through hereditary means or

environmental exposure. Most cancers (but not all) are manifested by a tumor.

The chance of a cancer patient to survive depends largely on how soon the

disease was diagnosed and given necessary treatments. Radical change in one’

s diet and lifestyle is also prescribed.

The Miracle Cure

Virgin coconut oil can be used as a weapon to fight cancer and save

precious lives. This statement is proven not only by numerous testimonies of

cancer survivors but with the results of medical studies.

Regular consumption of virgin coconut oil will strengthen the immune

system. Only a strong immune system can defeat the formation of cancer cells

before they can create major damage. Developing a strong immune system is the

first step in prevention and treatment of cancer and other diseases.

Virgin coconut oil can also cure skin cancer as proven in a study where

coconut oil is applied on the skin of mice which were applied with cancer

causing chemicals. Several applications of virgin coconut oil stopped tumor

development. Therefore, virgin coconut oil can alter the composition of tumor

tissue and thus inhibit tumor growth.

_http://www.thevirgincoconutoil.com/articleitem.php?articleid=168_

(http://www.thevirgincoconutoil.com/articleitem.php?articleid=168)

In the physiology department some recall how saturated _fats_

(http://www.bodybuilding.com/fun/bbinfo.php?page=Fat) were always deemed as

being very

bad. The rationale is based on saturated fat being associated with increased

_cholesterol_ (http://www.bodybuilding.com/fun/bbinfo.php?page=Cholesterol)

and consequently, heart disease (Margen et al., 1991; Marieb, 1998).

The mechanism of insult is based on a long-term progression of fatty

plaques occluding the lumen (Squires, 1998). This process is thought to occur

throughout daily life when there are abrupt increases in _blood pressure_

(http://www.bodybuilding.com/store/bloodmon.htm) from various causes and with

excess cholesterol floating around in the blood, the ruptures in the

endothelium are patched up by fatty acids (Sime et al., 1998). Over time, this

accumulation in the inner lining of the endothelium eventually leads to a

smaller vessel diameter and all it takes is one bolus of material to clog the

small lumen to trigger what is known as a myocardial infarction (heart

attack).

Personally, I believe that this physiological model on atherosclerosis is

true for the most part. However, I firmly believe that there are certain

vested interests and biased views from powers that be towards natural cures

and preventative methods (Fife, 2004; Trudeau, 2004; Trudeau, 2007).

Well, to my and in a few minutes, your amazement, it is (Dayrit, 2003). Let

me just impress the heck out of everyone by supporting this last statement

with some concrete and solid research studies, expert opinions and

scientific rationale.

Medium-Chain Triglycerides (MCT)

Coconut oil contains ~ 64% MCT (Dayrit, 2003; Fife, 2004). This is more

than any other food in existence. Research has clearly shown that MCT's are

thermogenic (Scalfi et al., 1991) and that less is stored away as body fat

(Papamandjaris et al., 2000; St-Onge & , 2002; St-Onge & , 2003).

The reason for this phenomenon is that the _MCT's_

(http://www.bodybuilding.com/store/mct.html) are rapidly absorbed from the

intestines directly

into the portal system and sent to the liver instead of through the lymphatic

system like all other fats; they also do not require carnitine for

transport and they are quickly oxidized and used for energy much like

_carbohydrates_ (http://www.bodybuilding.com/fun/bbinfo.php?page=Carbohydrates)

(Amarasiri & Dissanayake, 2006; Aoyama et al., 2007; Bach & Babayan, 1982;

Hashim,

1967; Manore et al., 1993; Pehowich et al., 2000).

View MCT's Sorted By Top Seller _Here_

(http://www.bodybuilding.com/store/mcttop.html) .

Research has shown coconut oil does not increase risk of _heart disease_

(http://www.bodybuilding.com/fun/bbinfo.php?page=HeartHealth) ( et al.,

1998; Elson, 1992; Kumar, 1997; Lindeberg, 1997; Lipoeto et al., 2004), and

in some research it actually lowers risk of heart disease (Kaunitz, 1986;

Prior et al., 1981). Other research has shown virgin coconut oil to lower

lipid levels by way of the biologically active polyphenol components present

in the oil (Nevin & Rajamohan, 2004).

On the contrary, coconut oil is mainly saturated fat. What is more

impressive is that if there was ever a healthy saturated fat, this is it!

Again,

with ~64% being MCT, it could be logically deducted that less than half of

the fat consumed will be stored as fat, provided the body is in the ideal

condition for such an occurrence. However, during a low-_calorie_

(http://www.bodybuilding.com/fun/bbinfo.php?page=Calories) cycle of which

either

_carbs_ (http://www.bodybuilding.com/fun/bbinfo.php?page=Carbohydrates) or

_fats_

(http://www.bodybuilding.com/fun/bbinfo.php?page=Fat) are reduced, with

_protein_ (http://www.bodybuilding.com/fun/bbinfo.php?page=Protein) being

kept normal to high normal, less fat will be stored away from coconut oil

since the body will be in a caloric deficit. Since the body will be in a

negative caloric balance, it will not want to store MCT as body fat, but

rather,

it will be scavenging for energy to try and provide energy! Thus, the MCT

from the coconut oil will be immediately oxidized for fuel, hence less

stored as body fat.

It is clear that saturated fat, but more in particular, _cholesterol_

(http://www.bodybuilding.com/fun/bbinfo.php?page=Cholesterol) , is needed for

_testosterone_ (http://www.bodybuilding.com/fun/bbinfo.php?page=Testosterone)

production (Marieb, 1998). Some cancers are treated with testosterone which

makes this another good reason for use with cancer patients. (LD

Wedewer,PhD) When trying to hold on to muscle while dieting, keeping protein

normal

to high-normal is essential in partitioning substrate oxidation towards

carbs and fats. However, several studies have shown that low saturated fat

diets lead to decreased testosterone production (Berrino et al., 2001;

Hamalainen et al., 1983; Hamalainen et al., 1984).

In essence, if one limits saturated fat content to prudent levels and

consumes cholesterol in prudent levels, one can see optimal testosterone

levels. It is typically when one eats excess of saturated fat and cholesterol

does the increase testosterone come along with the increased risk of prostate

cancer.

Testosterone does not cause prostate cancer, it is excess amounts of

saturated fat and cholesterol along with an unhealthy lifestyle that increases

risk. In addition to parasites, fungus and mold type bacterias, and cancer

causing viruses, this is a medical and scientific proof and why so many

people today are self treating their own cancers and curing it when modern

medicine can only place the cancer into remission awaiting 3 years to grow and

5-10 years to re-detect it's location (LD Wedewer, PhD) Having normal to

high testosterone levels actually reduce the risk of prostate cancer and can

be cardioprotective (Bain, 2007; Mearini et al., 2008).

Bruce Fife, N.D., says, " Every single one of us has cancerous cells in our

bodies. As long as As long as the immune system is functioning in the

manner for which it was designed, we need not worry about cancer. "

" In other words, cancer can only develop in those individuals whose immune

systems are so stressed or weakened that they are incapable of mounting an

effective defense. Thus, a healthy immune system is a key element in the

prevention of all forms of cancer, " he adds.

The anti-viral effects of MCFA's (medium-chain fatty acids) in Extra

virgin coconut oil has been studied, documented and proven by various research

groups here and in the US.

Cancer can be caused by a number of factors such as free radicals and

carcinogenic chemicals, the effects of which appear to be tempered by coconut

oil.

Other known causes are viruses. Human papillomavirus (HPV), for instance,

is found in virtually every case of cervical cancer.

Other viruses that may be linked to cancer include the Epstein-Barr virus,

ytomegalovirus and adenovirus.

Virgin coconut oil may be helpful in preventing these cancers because of

MCFA's anti-viral effects.

Researchers concluded that MCFA's enhance the immune system. A group of

researchers tested these hypotheses and found that monolaurin, a

monoglyceride of lauric acid, stimulates the production of white blood cells,

specifically T cells which attack and kill anything that is foreign to the

body,

including cancerous cells.

Another study shows that MCFA's can influence the fatty acid composition

of tumor tissue and tumor protein kinetics inhibiting tumor growth.

Virgin Coconut oil can also cure skin cancer as proven in a study where

Virgin Coconut oil is applied on the skin of mice which were applied with

cancer causing chemicals. Several applications of Virgin Coconut oil stopped

tumor development. Therefore, Virgin Coconut oil can alter the composition

of tumor tissue and thus inhibit tumor growth.

These pieces of evidence show that virgin coconut oil acts as a protective

anti-oxidant that stops the destructive action and cancer-promoting effect

of free radicals. It enhances the immune system, which actively fights

renegade cells and blocks the uncontrolled growth of cancer cells against the

mutagenic effects of carcinogens.

Lauric acid-rich Extra Virgin Coconut oil takes over the task of

destroying many of the invading microbes. And with less harmful organisms

around to

cause trouble, the white blood cells of your immune system are free to

search and destroy cancerous cells.

Only other natural source for Lauric acid is Human breast milk, which

provides a immune system to babies.

Virgin Coconut oil can be used as a weapon to fight cancer and save

precious lives. This statement is proven not only by numerous testimonies of

cancer survivors but with the results of medical studies.

Regular consumption of Virgin Coconut oil will strengthen the immune

system. Only a strong immune system can defeat the formation of cancer cells

before they can create major damage. Developing a strong immune system is the

first step in prevention and treatment of cancer and other diseases.

Pls visit Video on Virgin Coconut oil as treatment for Cancer : Researches

on Animals

_http://www.youtube.com/watch?v=hqNoPvESoc8_

(http://www.youtube.com/watch?v=hqNoPvESoc8)

_http://www.thevirgincoconutoil.com/articleitem.php?_

(http://www.thevirgincoconutoil.com/articleitem.php?)

_http://www.matrixvirgincoconutoil.com/page6.htm_

(http://www.matrixvirgincoconutoil.com/page6.htm)

Hawaiians call coconut water noelani (no-way lah-nee), which means “dew

from the heavens.†Coconut water has a long history of use as both a food and

as a medicine.

Coconut water contains a variety of nutrients including vitamins,

minerals, antioxidants, amino acids, enzymes, growth factors, and other

phytonutrients. Since coconuts are grown near the sea, the roots have access to

a

continual supply of mineral rich salt water. These minerals are absorbed by the

roots and find their way into the fruit of the coconut. For this reason,

coconut water is a good source of the major minerals like magnesium,

calcium, and potassium. It is particularly rich in potassium, an essential

nutrient; one 8-ounce cup of coconut water has more potassium than a banana. It

also contains a variety of trace elements such as zinc, selenium, iodine,

sulfur, manganese, boron, molybdenum, and others. All derived from volcanic

soils and seawater from which the coconut palms are grown. All of these

minerals are in the form of electrolytes so they are easily absorbable by the

human body. Many of the health benefits attributed to coconut water can be

traced to its mineral content.

The fat content of coconut water is so low it is essentially fat-free.

Coconut water is relatively low in sugar compared to other fruit juices. It

contains only a fifth of the sugar that you get from an equal amount of fresh

grape or apple juice. Even though it is low in sugar, it has a mildly

sweet, delightful taste, making it an excellent alternative to fruit juice and

sodas.

In regulating cell growth, cytokinins also prevent mistakes that may lead

to the development of cancer. Normal cells are kept healthy while cancerous

cells are programmed to die, preventing them from growing and spreading.

Much of the early research on cytokinins was funded by The American Cancer

Society. Soon after the discovery of cytokinins in the 1950s researchers

quickly recognized their potential in fighting cancer. Subsequently, the

anti-cancer effects of cytokinins have been well documented.5-6 References

1. Macalalag, E.V. and Macalalag, A.L. Bukolysis: young coconut water

renoclysis for urinary stone dissolution. Int Surg 1987;72:247.

2. Alleyne, T., et al. The control of hypertension by use of coconut water

and mauby: two tropical food drinks. West Indian Med J 2005;54:3-8.

3. Shah, N.J., et al. Use of coco-nut water in treatment of congestive

cardiac failure. Ind Jour Med Res 1956;44:341-351.

4. Rattan, S.I.S. and , B.F.C. Kinetin delays the onset of ageing

characteristics in human fibroblasts. Biochem Biophys Res 1994;201:665-672.

5. Adair, W.L. and Brennan, S.L. The role of N-6-isopentenyl adenine in

tumor cell growth. Biochem Biophys Res Commun 1986;137:208-214.

6. Dolezal, K, et al. Preparation and biological activity of

6-benzylaminopurine derivatives in plants and human cancer cells. Bioorg Med

Chem

2006;14:875-874.

Coconut oil provides a quick and easy source of nutrition because of it is

easily digested and aids assimilation of other nutrients. For this reason

it has been recommended in the treatment of malnutrition (which can be a

problem in a person suffering from pancreatic cancer). Coconut oil can help

with fatigue and a whole range of conditions because its antimicrobial

effects defeat organisms in the body, which may be draining the body's strength

and causative to the condition.

COCO SAP AND CANCER. Administrator Garin likewise highlighted the

potential of fresh coco sap or toddy which contains inositol in the medication

of

cancer patients. “We have to develop a way of prolonging the shelf life of

coco sap while maintaining its fresh and pure form, and the validation as

well as of the health benefits through a clinical study,†he said.

_http://www.mb.com.ph/node/233503/pca-urge_

(http://www.mb.com.ph/node/233503/pca-urge)

When Albert Schweitzer operated his clinic in tropical Africa, he said it

was many years before he saw any cases of cancer, and he believed that the

appearance of cancer was caused by the change to the European type of diet.

In the l920s, German researchers showed that mice on a fat-free diet were

practically free of cancer. Since then, many studies have demonstrated a

very close association between consumption of unsaturated oils and the

incidence of cancer. Heart damage is easily produced in animals by feeding them

linoleic acid; this " essential " fatty acid turned out to be the heart toxin

in rape-seed oil.

The addition of saturated fat to the experimental heart-toxic oil-rich

diet protects against the damage to heart cells. Immunosuppression was

observed in patients who were being " nourished " by intravenous emulsions of

" essential fatty acids, " and as a result coconut oil is used as the basis for

intravenous fat feeding, except in organ-transplant patients. For those

patients, emulsions of unsaturated oils are used specifically for their

immunosuppressive effects.

General aging, and especially aging of the brain, is increasingly seen as

being closely associated with lipid peroxidation. Several years ago I met

an old couple, who were only a few years apart in age, but the wife looked

many years younger than her doddering old husband. She was from the

Philippines, and she remarked that she always had to cook two meals at the same

time, because her husband couldn't adapt to her traditional food. Three times

every day, she still prepared her food in coconut oil. Her apparent youth

increased my interest in the effects of coconut oil.

But other researchers who were studying vitamin B6 recognized the

condition as a deficiency of that vitamin. They were able to cause the

condition by

feeding a fat-free diet, and to cure the condition by feeding a single B

vitamin. The hypermetabolic animals simply needed a better diet than the

" normal, " fat-fed, cancer-prone animals did. G. W. Crile and his wife found

that the metabolic rate of people in Yucatan, where coconut is a staple food,

averaged 25% higher than that of people in the United States. In a hot

climate, the adaptive tendency is to have a lower metabolic rate, so it is

clear that some factor is more than offsetting this expected effect of high

environmental temperatures. The people there are lean, and recently it has

been observed that the women there have none of the symptoms we commonly

associate with the menopause

However, in 1980, experimenters demonstrated that young rats fed milk

containing soy oil incorporated the oil directly into their brain cells, and

had structurally abnormal brain cells as a result. Lipid peroxidation occurs

during seizures, and antioxidants such as vitamin E have some anti-seizure

activity. Currently, lipid peroxidation is being found to be involved in

the nerve cell degeneration of Alzheimer's disease. Various fractions of

coconut oil are coming into use as " drugs, " meaning that they are advertised as

treatments for diseases. Butyric acid is used to treat cancer, lauric and

myristic acids to treat virus infections, and mixtures of medium-chain fats

are sold for weight loss. Purification undoubtedly increases certain

effects, and results in profitable products, but in the absence of more precise

knowledge, I think the whole natural product, used as a regular food, is

the best way to protect health.

When people become interested in coconut oil as a " health food, " the huge

seed-oil industry--operating through their shills--are going to attack it

as an " unproved drug. " While components of coconut oil have been found to

have remarkable physiological effects (as antihistamines,

antiinfectives/antiseptics, promoters of immunity, glucocorticoid antagonist,

nontoxic

anticancer agents, for example), I think it is important to avoid making any

such

claims for the natural coconut oil, because it very easily could be banned

from the import market as a " new drug " which isn't " approved by the FDA. "

Now, it seems that the effect is just one more toxic action, in which the

liver defensively retains its cholesterol, rather than releasing it into

the blood. Large scale human studies have provided overwhelming evidence that

whenever drugs, including the unsaturated oils, were used to lower serum

cholesterol, mortality increased, from a variety of causes including

accidents, but mainly from cancer. Since the l930s, it has been clearly

established that suppression of the thyroid raises serum cholesterol (while

increasing mortality from infections, cancer, and heart disease), while

restoring

the thyroid hormone brings cholesterol down to normal. In this situation,

however, thyroid isn't suppressing the synthesis of cholesterol, but rather is

promoting its use to form hormones and bile salts. When the thyroid is

functioning properly, the amount of cholesterol in the blood entering the

ovary governs the amount of progesterone being produced by the ovary, and the

same situation exists in all steroid-forming tissues, such as the adrenal

glands and the brain. Progesterone and its precursor, pregnenolone, have a

generalized protective function: antioxidant, anti-seizure, antitoxin,

anti-spasm, anti-clot, anti-cancer, pro-memory, pro-myelination, pro-attention,

etc.

Any interference with the formation of cholesterol will interfere with all

of these exceedingly important protective functions. As far as the

evidence goes, it suggests that coconut oil, added regularly to a balanced

diet,

lowers cholesterol to normal by promoting its conversion into pregnenolone.

(The coconut family contains steroids that resemble pregnenolone, but these

are probably mostly removed when the fresh oil is washed with water to

remove the enzymes which would digest the oil.)

Studies in Sri Lanka

In 1989, a Sri Lankan study conducted by Prof. Shanti Mendis, using male

participants showed that when coconut oil is replaced by corn oil, the total

blood cholesterol, good (HDL) cholesterol and bad (LDL) cholesterol were

similarly decreased. The study found however that consumption of coconut

oil, raised both LDL and HDL, and also had the undesirable effect of raising

the LDL to HDL ratio. Adding further to the complexity of the subject, Prof.

Mendis also found in a subsequent study, that when coconut oil consumption

is reduced and that amount is replaced with polyunsaturated oils such as

sunflower or sesame oil, total cholesterol and bad cholesterol (LDL) can be

reduced without reducing good cholesterol (HDL). It seems therefore, that

coconut oil (saturated fat) raised both HDL and LDL, though not

proportionally (the LDL: HDL is increased), while polyunsaturated oils decrease

both.

The “buzz on the street†about coconut oil’s benefits is firmly grounded

in science. Saturated fats in general enhance the immune system,3 and

coconut oil in particular increases body temperature and is preferentially used

by the body for energy rather than storage.4 The claim about benefits to

blood pressure is not one that I have ever made, and as far as I know, there

are no human studies that have looked at the effect of coconut oil on blood

pressure.

The story is a report by Dr. Newport, a neonatologist and medical

director of the newborn intensive care unit at Spring Hill Regional Hospital

in Florida. About six years ago, her husband, an accountant who worked at

home, began struggling with daily tasks. His deterioration progressed and he

was eventually diagnosed with early onset Alzheimer’s. Dr. Newport searched

the Internet for clinical drug trials that would accept her husband and

discovered that a drug containing medium-chain triglycerides, the kind of fat

in coconut oil, had achieved remarkable results—not just slowing the

progression of the disease but providing real improvement.

She decided to give her husband coconut oil, two tablespoons per day, and

her husband immediately improved, scoring 18 on a cognitive assessment, four

points higher than he had scored the previous day. Within a week he showed

tremendous improvement and five months later her husband was leading a

relatively normal life, although still unable to resume his work as an

accountant, apparently due to permanent brain damage.

Coconut oil holds potential in the treatment of cancer as well, as several

studies have indicated coconut oil’s anticarcinogenic effects.15

Lim-Sylianco CY. Anticarcinogenic effect of coconut oil. The Philippine

Journal of Coconut Studies 12:89-102;1987; Reddy BS, Maeura Y. Tumor

promotion of dietary fat in azoxymethane-induced colon carcinogenesis in female

F

344 rats. Journal of the National Cancer Institute 72:745- 750;1984; Cohen

LA and others. Dietary fat and mammary cancer. I. Promoting effects of

different dietary fats on N-nitrosomethylurea-induced rat mammary

tumorigenesis.

Journal of the National Cancer Institute 77:33;1986; Cohen LA and others.

Dietary fat and mammary cancer. II. Modulation of serum and tumor lipid

composition and tumor prostaglandins by different dietary fats: Association

with tumor incidence patterns. Journal of the National Cancer Institute

77:43;1986.

G. Enig, PhD is an expert of international renown in the field of

lipid biochemistry. She has headed a number of studies on the content and

effects of trans fatty acids in America and Israel, and has successfully

challenged government assertions that dietary animal fat causes cancer and

heart

disease. Recent scientific and media attention on the possible adverse

health effects of trans fatty acids has brought increased attention to her

work. She is a licensed nutritionist, certified by the Certification Board for

Nutrition Specialists, a qualified expert witness, nutrition consultant to

individuals, industry and state and federal governments, contributing

editor to a number of scientific publications, Fellow of the American College

of

Nutrition and President of the land Nutritionists Association. She is

the author of over 60 technical papers and presentations, as well as a

popular lecturer. Dr. Enig is currently working on the exploratory development

of an adjunct therapy for AIDS using complete medium chain saturated fatty

acids from whole foods. She is Vice-President of the Weston A Price

Foundation and Scientific Editor of Wise Traditions as well as the author of

Know

Your Fats: The Complete Primer for Understanding the Nutrition of Fats,

Oils, and Cholesterol, Bethesda Press, May 2000. She is the mother of three

healthy children brought up on whole foods including butter, cream, eggs and

meat.

Tocotrienols and stroke-induced Injuries

In the peer-reviewed Stroke journal (Oct 2005), oral supplementation of a

natural full spectrum palm tocotrienol complex to spontaneously

hypertensive rats led to increased tocotrienols level in the brain. The rats,

supplemented with tocotrienols, showed more protection against stroke-induced

injury compared to controls (non-supplemented group). This study demonstrated

that oral supplementation of the palm tocotrienol complex acts on key

molecular checkpoints (c-Src and 12-Lipoxygenase) to protect against glutamate-

and stroke-induced neurodegeneration and ultimately protect against stroke in

vivo._[37]_ (http://en.wikipedia.org/wiki/Tocotrienol#cite_note-36) The

protective effects of tocotrienols are independent of their antioxidant

activity because tocopherols were effective only at higher concentrates._[38]_

(http://en.wikipedia.org/wiki/Tocotrienol#cite_note-37)

In 2005, a study jointly undertaken at Wayne State University and Ohio

State University Medical Center show that tocotrienol can be efficiently

delivered to organs and could therefore offer the health benefits suggested by

in vitro and in vivo studies._[39]_

(http://en.wikipedia.org/wiki/Tocotrienol#cite_note-38) " Our results

demonstrate that tocotrienols is efficiently

delivered to the bloodstream despite the fact that the transfer protein has

a lower affinity for tocotrienols than it has for tocopherols, " said

Chandan Sen of Ohio State University and senior author of the study.[_cite this

quote_

(http://en.wikipedia.org/wiki/Wikipedia:Quotations#How_to_use_quotations) ]

The researchers recruited women with normal cholesterol levels (average age

of 23.5 years old) and gave them a fat-rich strawberry smoothie containing

400 mg of vitamin E containing 77 mg alpha-tocotrienol, 96 mg

delta-tocotrienol, and 3 mg gamma-tocotrienol, plus tocopherols. Since vitamin

E is a

fat-soluble vitamin, the researchers chose to deliver the micronutrient in

a fat-loaded meal in order to improve absorption. Blood measurements in the

post-prandial period showed that maximal alpha-tocotrienol levels averaged

almost 3 micromoles in blood plasma, 1.7 micromoles in low density

lipoproteins, and 0.5 micromoles in high density lipoproteins. " This work

present

first evidence demonstrating the post-absorptive fate of tocotrienol

isomers and their association with lipoprotein subfractions in humans, " wrote

lead author Pramod Khosla of Wayne State University.[_cite this quote_

(http://en.wikipedia.org/wiki/Wikipedia:Quotations#How_to_use_quotations) ]

These concentrations, say the researchers, are sufficient to support the

proposed neuro-protective functions of tocotrienol. " We have determined that

when administered orally, tocotrienol can reach concentrations needed to

serve these… protective functions, " said Sen. " It is a regular dietary

ingredient in Asia, so it can safely be a part of a daily diet within prepared

foods or as a supplement in the United States. " Can it be therapeutically

used to prevent stroke? " Results from animal studies are encouraging, but it

is still too soon to tell for humans, " he added.[_cite this quote_

(http://en.wikipedia.org/wiki/Wikipedia:Quotations#How_to_use_quotations) ]

[_edit_

(http://en.wikipedia.org/w/index.php?title=Tocotrienol & action=edit & section=7) ]

Tocotrienols and pancreatic cancer

Pancreatic cancer represents the fourth-leading cause of cancer death in

the United States, with a dismal 5-year survival rate of less than 5%. Early

detection and screening for pancreatic cancer in the current state should

be limited to high-risk patients, although hereditary/familial factors

account for only 10% of patients with pancreatic cancer._[40]_

(http://en.wikipedia.org/wiki/Tocotrienol#cite_note-39) _[41]_

(http://en.wikipedia.org/wiki/Tocotrienol#cite_note-40)

Tocotrienols are more effective antioxidants than tocopherols because its

unsaturated _side chain_ (http://en.wikipedia.org/wiki/Side_chain)

facilitate better penetration into saturated fatty layers of the _brain_

(http://en.wikipedia.org/wiki/Brain) _[42]_

(http://en.wikipedia.org/wiki/Tocotrienol#cite_note-41) and _liver_

(http://en.wikipedia.org/wiki/Liver) ._[43]_

(http://en.wikipedia.org/wiki/Tocotrienol#cite_note-42) Tocotrienols can

lower _tumor_ (http://en.wikipedia.org/wiki/Tumor) formation,_[44]_

(http://en.wikipedia.org/wiki/Tocotrienol#cite_note-43) _DNA_

(http://en.wikipedia.org/wiki/DNA) damage and _cell_

(http://en.wikipedia.org/wiki/Cell_(biology))

damage._[45]_ (http://en.wikipedia.org/wiki/Tocotrienol#cite_note-44) In

a 1993 study where rats were induced with potent liver cancer agent,

scientists found less liver cell damage in the group fed with palm

tocotrienols._[24]_

(http://en.wikipedia.org/wiki/Tocotrienol#cite_note-pmid19367124-23)

_[46]_ (http://en.wikipedia.org/wiki/Tocotrienol#cite_note-45)

In 2009, scientists at Department of Nutrition and Food Sciences, Texas

Woman's University evaluated the impact of d-delta-tocotrienol, a potent

vitamin E isomer, on human MIA PaCa-2 and PANC-1 pancreatic carcinoma cells and

BxPC-3 pancreatic ductal adenocarcinoma cells. They concluded suppression

of mevalonate pathway activities, be it by modulators of HMG CoA reductase

(statins, tocotrienols, and farnesol), farnesyl transferase (farnesyl

transferase inhibitors), and/or mevalonate pyrophosphate decarboxylase

(phenylacetate) activity, have a potential in pancreatic cancer

chemotherapy._[47]_

(http://en.wikipedia.org/wiki/Tocotrienol#cite_note-46) Moreover, a Phase

I dose-escalating study evaluating the effect of a pure Tocotrienol delta

isomer extracted from palm oil towards individuals with Pancreatic cancer is

currently underway at the Moffitt Cancer Centre, and is the first time

tocotrienol has been clinically evaluated in humans towards cancer._[48]_

(http://en.wikipedia.org/wiki/Tocotrienol#cite_note-47)

[_edit_

(http://en.wikipedia.org/w/index.php?title=Tocotrienol & action=edit & section=8) ]

Tocotrienols and breast cancer

In the 1990s, studies showed tocotrienols are the components of vitamin E

responsible for growth inhibition in human _breast cancer_

(http://en.wikipedia.org/wiki/Breast_cancer) cells _in vitro_

(http://en.wikipedia.org/wiki/In_vitro) ,_[49]_

(http://en.wikipedia.org/wiki/Tocotrienol#cite_note-48)

through estrogen-independent mechanisms._[50]_

(http://en.wikipedia.org/wiki/Tocotrienol#cite_note-49) Tocotrienols work

synergistically with

tamoxifen, a commonly used breast cancer medicine, in killing cancer

cells._[51]_

(http://en.wikipedia.org/wiki/Tocotrienol#cite_note-50)

Tocotrienols can also affect cell _homeostasis_

(http://en.wikipedia.org/wiki/Homeostasis) , possibly independently of their

antioxidant

activity._[52]_ (http://en.wikipedia.org/wiki/Tocotrienol#cite_note-51)

Anti-cancer

effects of α- and γ-tocotrienol have been reported, although δ-tocotrienol

was

verified to be the most effective tocotrienol in inducing _apoptosis_

(http://en.wikipedia.org/wiki/Apoptosis) _[53]_

(http://en.wikipedia.org/wiki/Tocotrienol#cite_note-52) (cell death) in

estrogen-responsive and

estrogen-nonresponsive human breast cancer cells. Based on these results on

cells in

culture, investigators have hypothesised that a mixture of α- and γ

-tocotrienols might reduce breast cancer risk._[54]_

(http://en.wikipedia.org/wiki/Tocotrienol#cite_note-53)

Further studies on tocotrienol and breast cancer indicated that

gamma-tocotrienol targets cancer cells by inhibiting Id1, a key

cancer-promoting

protein. Gamma-tocotrienol was shown to trigger cell apoptosis and well as

anti-proliferation of cancer cells. This mechanism was also observed in

separate prostate cancer and melanoma cell line studies_[55]_

(http://en.wikipedia.org/wiki/Tocotrienol#cite_note-54) .

In 2009, a study by scientists at the College of Pharmacy, University of

Louisiana at Monroe showed statins and tocotrienols provide significant

health benefits in the treatment of breast cancer in women, while avoiding

myotoxicity associated with high dose statin monotherapy._[56]_

(http://en.wikipedia.org/wiki/Tocotrienol#cite_note-55)

[_edit_

(http://en.wikipedia.org/w/index.php?title=Tocotrienol & action=edit & section=9) ]

Tocotrienols and prostate cancer

Investigation of the _antiproliferative_

(http://en.wikipedia.org/wiki/Antiproliferative) effect of tocotrienols in PC3

and LNCaP _prostate cancer_

(http://en.wikipedia.org/wiki/Prostate_cancer) cells suggests that the

transformation of vitamin E to CEHC is mostly a _detoxification_

(http://en.wikipedia.org/wiki/Detoxification) mechanism, useful to maintain the

malignant

properties of prostate cancer cells._[57]_

(http://en.wikipedia.org/wiki/Tocotrienol#cite_note-56) However, recent

research suggested that γ

-tocotrienol was most potent in suppressing prostate cancer cell proliferation,

and

that the antiproliferative effect of γ-tocotrienol act through

multiple-signalling pathways (NF-B, EGF-R and Id family proteins). In addition,

the

same study demonstrated the anti-invasion and chemosensitisation effect of γ

-tocotrienol against PCa cells._[58]_

(http://en.wikipedia.org/wiki/Tocotrienol#cite_note-57)

[_edit_

(http://en.wikipedia.org/w/index.php?title=Tocotrienol & action=edit & section=10) ]

Tocotrienols and skin cancer

In a 2009 study at the Li Ka Shing Faculty of Medicine, The University of

Hong Kong, scientists found reduction in skin cancer cells when treated with

gamma-tocotrienol with chemotherapy drugs. For the first time,

researchers recorded the anti-invasion and chemonsensitization effect of

gamma-tocotrienol against human malignant melanoma cells._[59]_

(http://en.wikipedia.org/wiki/Tocotrienol#cite_note-58)

[_edit_

(http://en.wikipedia.org/w/index.php?title=Tocotrienol & action=edit & section=11) ]

Tocotrienols and cholesterol reduction

The human body makes cholesterol from the liver, producing about 1g of

_cholesterol_ (http://en.wikipedia.org/wiki/Cholesterol) each day or 80% of the

needed total body cholesterol. The remaining 20% comes from what we eat.

Excessive cholesterol is a health risk because gradual fatty deposit clog up

the arteries. This will cause blood flow to the brain, heart, kidneys and

other parts of the body become less efficient.

_Cholesterol_ (http://en.wikipedia.org/wiki/Cholesterol) , though needed

metabolically, is not essential in diet. Tocotrienols can decrease the

liver's capacity to manufacture cholesterol. It does so by suppressing the

HMG-CoA reductase, the enzyme in the liver responsible for cholesterol

synthesis._[20]_

(http://en.wikipedia.org/wiki/Tocotrienol#cite_note-pmid8388388-19)

In 1993, American scientists conducted a double-blind placebo controlled

study of 50 volunteers at the Jordan Heart Foundation and Elmhurst

Medical Center. Their results suggested that palm tocotrienols could ease

clogged arteries. Seven high cholesterol patients with narrowing arteries

experienced reverse arterial blockage of the carotid artery after consuming

palm tocotrienols, while in two the conditioned worsened._[16]_

(http://en.wikipedia.org/wiki/Tocotrienol#cite_note-Tomeo_AC.2C_Geller_M.2C_Watk\

ins_TR.2C_G

apor_A.2C_Bierenbaum_ML_1995_1179.E2.80.9383-15) This compared to the

control group, where none improved and ten worsened.

Tocotrienols, especially δ- and γ-tocotrienols, were shown to be effective

nutritional agents in treating high cholesterol. In particular, γ

-tocotrienol appears to act on a specific _enzyme_

(http://en.wikipedia.org/wiki/Enzyme) called

3-hydroxy-3-methylglutaryl-coenzyme and suppresses the

production of this enzyme, resulting in less cholesterol being manufactured by

liver cells._[60]_ (http://en.wikipedia.org/wiki/Tocotrienol#cite_note-59)

While a 1995 study in chickens indicated that the presence of dietary

alpha-tocopherol may interfere with tocotrienol's ability to lower cholesterol

_[61]_ (http://en.wikipedia.org/wiki/Tocotrienol#cite_note-60) although a

later study found the interference was seen towards alpha-tocotrienol

only._[62]_ (http://en.wikipedia.org/wiki/Tocotrienol#cite_note-61)

[_edit_

(http://en.wikipedia.org/w/index.php?title=Tocotrienol & action=edit & section=12) ]

Tocotrienols and diabetes

According to the World Health Organization (WHO), 170 million people were

affected by diabetes in the year 2002, and this number is likely to increase

to 366 million by the year 2030._[63]_

(http://en.wikipedia.org/wiki/Tocotrienol#cite_note-62) Diabetes mellitus (DM)

has been recognized as the

sole independent risk factor for the development of any cardiovascular

disease._[64]_ (http://en.wikipedia.org/wiki/Tocotrienol#cite_note-63)

Cardiovascular complications include stroke and heart attack, are increasingly

causing

death in diabetic patients. Alarmingly, literature statistics indicate

that atherosclerosis accounts for about 8 to 10% of all diabetic deaths._[65]_

(http://en.wikipedia.org/wiki/Tocotrienol#cite_note-64)

Recent studies are showing that vitamin E intake significantly reduce risk

of type 2 diabetes. The relative risk (RR) of type 2 diabetes between the

extreme quartiles of the intake was 0.69 (95% CI 0.51-0.94, P for

trend=0.003). Intakes of alpha-tocopherol, gamma-tocopherol, delta-tocopherol,

and

beta-tocotrienol were inversely related to a risk of type 2 _diabetes_

(http://en.wikipedia.org/wiki/Diabetes) . While _correlation does not imply

causation_ (http://en.wikipedia.org/wiki/Correlation_does_not_imply_causation) ,

these data suggest the possibility that the development of type 2 diabetes

might be modified by the intake of antioxidants in the diet._[66]_

(http://en.wikipedia.org/wiki/Tocotrienol#cite_note-65)

In 2009, animal trials carried out in India and Malaysia revealed palm

tocotrienols improved blood glucose, dyslipidemia and oxidative stress in

diabetic rats. It is able to prevent the progression of vascular wall changes

occurring in DM._[67]_

(http://en.wikipedia.org/wiki/Tocotrienol#cite_note-66) _[68]_

(http://en.wikipedia.org/wiki/Tocotrienol#cite_note-67)

[_edit_

(http://en.wikipedia.org/w/index.php?title=Tocotrienol & action=edit & section=13) ]

No-observed-adverse-effect level

A 13-week study by H. Nakamura and colleagues at the _National Institute of

Health Sciences (Japan)_

(http://en.wikipedia.org/w/index.php?title=National_Institute_of_Health_Sciences\

_(Japan) & action=edit & redlink=1) of

tocotrienols' toxicity in rats found significant changes in several blood

components, increases in liver weights and (in females) reductions in ovary and

uterus weights, depending on the dosages. The authors estimated the

no-observed-adverse-effect level (NOAEL) to be 120 mg per kg of body weight per

day for

males and 130 mg per kg of body weight per day for females. Since effects

on the blood components were observed in all cases with non-placebos, a

no-observed-effect level (NOEL) could not be determined._[35]_

(http://en.wikipedia.org/wiki/Tocotrienol#cite_note-rats_lose_red_cells-34)

[_edit_

(http://en.wikipedia.org/w/index.php?title=Tocotrienol & action=edit & section=14) ]

See also

* _Lycopene_ (http://en.wikipedia.org/wiki/Lycopene)

[_edit_

(http://en.wikipedia.org/w/index.php?title=Tocotrienol & action=edit & section=15) ]

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65. _^_ (http://en.wikipedia.org/wiki/Tocotrienol#cite_ref-64) Gu K,

Cowie CC, MI (July 1998). " Mortality in adults with and without

diabetes in a national cohort of the U.S. population, 1971-1993 " . Diabetes Care

21 (7): 1138–45. _doi_

(http://en.wikipedia.org/wiki/Digital_object_identifier)

:_10.2337/diacare.21.7.1138_

(http://dx.doi.org/10.2337/diacare.21.7.1138) . _PMID_

(http://en.wikipedia.org/wiki/PubMed_Identifier) _9653609_

(http://www.ncbi.nlm.nih.gov/pubmed/9653609) .

66. _^_ (http://en.wikipedia.org/wiki/Tocotrienol#cite_ref-65)

Montonen J, Knekt P, Järvinen R, Reunanen A (February 2004). " Dietary

antioxidant

intake and risk of type 2 diabetes " . Diabetes Care 27 (2): 362–6. _doi_

(http://en.wikipedia.org/wiki/Digital_object_identifier)

:_10.2337/diacare.27.2.362_ (http://dx.doi.org/10.2337/diacare.27.2.362) .

_PMID_

(http://en.wikipedia.org/wiki/PubMed_Identifier) _14747214_

(http://www.ncbi.nlm.nih.gov/pubmed/14747214) .

67. _^_ (http://en.wikipedia.org/wiki/Tocotrienol#cite_ref-66) Kuhad

A, Bishnoi M, Tiwari V, Chopra K (April 2009). " Suppression of NF-kappabeta

signaling pathway by tocotrienol can prevent diabetes associated cognitive

deficits " . Pharmacology, Biochemistry, and Behavior 92 (2): 251–9. _doi_

(http://en.wikipedia.org/wiki/Digital_object_identifier)

:_10.1016/j.pbb.2008.12.012_ (http://dx.doi.org/10.1016/j.pbb.2008.12.012) .

_PMID_

(http://en.wikipedia.org/wiki/PubMed_Identifier) _19138703_

(http://www.ncbi.nlm.nih.gov/pubmed/19138703) .

68. _^_ (http://en.wikipedia.org/wiki/Tocotrienol#cite_ref-67) Budin

SB, Othman F, Louis SR, Bakar MA, Das S, Mohamed J (June 2009). _ " The

effects of palm oil tocotrienol-rich fraction supplementation on biochemical

parameters, oxidative stress and the vascular wall of streptozotocin-induced

diabetic rats " _

(http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez & artid=266644\

7) . Clinics 64 (3): 235–44. _doi_

(http://en.wikipedia.org/wiki/Digital_object_identifier)

:_10.1590/S1807-59322009000300015_

(http://dx.doi.org/10.1590/S1807-59322009000300015) . _PMID_

(http://en.wikipedia.org/wiki/PubMed_Identifier) _19330251_

(http://www.ncbi.nlm.nih.gov/pubmed/19330251) .

[Guest guest]

Wow. Awesome Deal. Ill look into this and see what helps me out.

Thank you so much, I really appreciate it!

Have the best day ever!

Tyron.

>

> Virgin Coconut and Cancer

> Research by: LD Wedewer PhD

> Cancer research, studies, and reviews (short list)

> There are some things in this world that we all dread to hear. Something no

> one hopes to experience. And a physician confirming that you are afflicted

> with fatal cancer is definitely one of it! But thanks to virgin coconut

> oil, there is after all a way out of this seemingly hopeless situation.

> It is a sad truth that so many people are afflicted with this fatal

> disease. Cancer ranks second in the leading cause of death statistics of the

> United States. It is said that approximately one million people acquire

cancer

> each year.

> There are various types of cancer but one characteristic that all cancer

> diseases share is the rapid growth of abnormal cells in the body. Normal

> cells follow a regular cycle of growth, division and death. In the early

stage

> of life, there is rapid cellular activity. But cells of a healthy adult

> person only divide to replace dying cells and to heal damage caused by

> injuries.

> Cancer cells keep on growing and dividing and create abnormal cells. Cancer

> cells may spread and cause problems to other parts of the body. This is

> triggered by a damage to DNA. Unlike normal cells, cancer cells cannot

> repair damaged DNA. Damaged DNA can be acquired through hereditary means or

> environmental exposure. Most cancers (but not all) are manifested by a tumor.

> The chance of a cancer patient to survive depends largely on how soon the

> disease was diagnosed and given necessary treatments. Radical change in one’

> s diet and lifestyle is also prescribed.

> The Miracle Cure

> Virgin coconut oil can be used as a weapon to fight cancer and save

> precious lives. This statement is proven not only by numerous testimonies of

> cancer survivors but with the results of medical studies.

> Regular consumption of virgin coconut oil will strengthen the immune

> system. Only a strong immune system can defeat the formation of cancer cells

> before they can create major damage. Developing a strong immune system is the

> first step in prevention and treatment of cancer and other diseases.

> Virgin coconut oil can also cure skin cancer as proven in a study where

> coconut oil is applied on the skin of mice which were applied with cancer

> causing chemicals. Several applications of virgin coconut oil stopped tumor

> development. Therefore, virgin coconut oil can alter the composition of tumor

> tissue and thus inhibit tumor growth.

> _http://www.thevirgincoconutoil.com/articleitem.php?articleid=168_

> (http://www.thevirgincoconutoil.com/articleitem.php?articleid=168)

> In the physiology department some recall how saturated _fats_

> (http://www.bodybuilding.com/fun/bbinfo.php?page=Fat) were always deemed as

being very

> bad. The rationale is based on saturated fat being associated with increased

> _cholesterol_ (http://www.bodybuilding.com/fun/bbinfo.php?page=Cholesterol)

> and consequently, heart disease (Margen et al., 1991; Marieb, 1998).

> The mechanism of insult is based on a long-term progression of fatty

> plaques occluding the lumen (Squires, 1998). This process is thought to occur

> throughout daily life when there are abrupt increases in _blood pressure_

> (http://www.bodybuilding.com/store/bloodmon.htm) from various causes and with

> excess cholesterol floating around in the blood, the ruptures in the

> endothelium are patched up by fatty acids (Sime et al., 1998). Over time,

this

> accumulation in the inner lining of the endothelium eventually leads to a

> smaller vessel diameter and all it takes is one bolus of material to clog the

> small lumen to trigger what is known as a myocardial infarction (heart

> attack).

> Personally, I believe that this physiological model on atherosclerosis is

> true for the most part. However, I firmly believe that there are certain

> vested interests and biased views from powers that be towards natural cures

> and preventative methods (Fife, 2004; Trudeau, 2004; Trudeau, 2007).

> Well, to my and in a few minutes, your amazement, it is (Dayrit, 2003). Let

> me just impress the heck out of everyone by supporting this last statement

> with some concrete and solid research studies, expert opinions and

> scientific rationale.

>

> Medium-Chain Triglycerides (MCT)

> Coconut oil contains ~ 64% MCT (Dayrit, 2003; Fife, 2004). This is more

> than any other food in existence. Research has clearly shown that MCT's are

> thermogenic (Scalfi et al., 1991) and that less is stored away as body fat

> (Papamandjaris et al., 2000; St-Onge & , 2002; St-Onge & , 2003).

> The reason for this phenomenon is that the _MCT's_

> (http://www.bodybuilding.com/store/mct.html) are rapidly absorbed from the

intestines directly

> into the portal system and sent to the liver instead of through the lymphatic

> system like all other fats; they also do not require carnitine for

> transport and they are quickly oxidized and used for energy much like

> _carbohydrates_

(http://www.bodybuilding.com/fun/bbinfo.php?page=Carbohydrates)

> (Amarasiri & Dissanayake, 2006; Aoyama et al., 2007; Bach & Babayan, 1982;

Hashim,

> 1967; Manore et al., 1993; Pehowich et al., 2000).

> View MCT's Sorted By Top Seller _Here_

> (http://www.bodybuilding.com/store/mcttop.html) .

>

> Research has shown coconut oil does not increase risk of _heart disease_

> (http://www.bodybuilding.com/fun/bbinfo.php?page=HeartHealth) ( et al.,

> 1998; Elson, 1992; Kumar, 1997; Lindeberg, 1997; Lipoeto et al., 2004), and

> in some research it actually lowers risk of heart disease (Kaunitz, 1986;

> Prior et al., 1981). Other research has shown virgin coconut oil to lower

> lipid levels by way of the biologically active polyphenol components present

> in the oil (Nevin & Rajamohan, 2004).

>

>

> On the contrary, coconut oil is mainly saturated fat. What is more

> impressive is that if there was ever a healthy saturated fat, this is it!

Again,

> with ~64% being MCT, it could be logically deducted that less than half of

> the fat consumed will be stored as fat, provided the body is in the ideal

> condition for such an occurrence. However, during a low-_calorie_

> (http://www.bodybuilding.com/fun/bbinfo.php?page=Calories) cycle of which

either

> _carbs_ (http://www.bodybuilding.com/fun/bbinfo.php?page=Carbohydrates) or

_fats_

> (http://www.bodybuilding.com/fun/bbinfo.php?page=Fat) are reduced, with

> _protein_ (http://www.bodybuilding.com/fun/bbinfo.php?page=Protein) being

> kept normal to high normal, less fat will be stored away from coconut oil

> since the body will be in a caloric deficit. Since the body will be in a

> negative caloric balance, it will not want to store MCT as body fat, but

rather,

> it will be scavenging for energy to try and provide energy! Thus, the MCT

> from the coconut oil will be immediately oxidized for fuel, hence less

> stored as body fat.

> It is clear that saturated fat, but more in particular, _cholesterol_

> (http://www.bodybuilding.com/fun/bbinfo.php?page=Cholesterol) , is needed for

> _testosterone_ (http://www.bodybuilding.com/fun/bbinfo.php?page=Testosterone)

> production (Marieb, 1998). Some cancers are treated with testosterone which

> makes this another good reason for use with cancer patients. (LD

> Wedewer,PhD) When trying to hold on to muscle while dieting, keeping protein

normal

> to high-normal is essential in partitioning substrate oxidation towards

> carbs and fats. However, several studies have shown that low saturated fat

> diets lead to decreased testosterone production (Berrino et al., 2001;

> Hamalainen et al., 1983; Hamalainen et al., 1984).

> In essence, if one limits saturated fat content to prudent levels and

> consumes cholesterol in prudent levels, one can see optimal testosterone

> levels. It is typically when one eats excess of saturated fat and cholesterol

> does the increase testosterone come along with the increased risk of prostate

> cancer.

> Testosterone does not cause prostate cancer, it is excess amounts of

> saturated fat and cholesterol along with an unhealthy lifestyle that

increases

> risk. In addition to parasites, fungus and mold type bacterias, and cancer

> causing viruses, this is a medical and scientific proof and why so many

> people today are self treating their own cancers and curing it when modern

> medicine can only place the cancer into remission awaiting 3 years to grow

and

> 5-10 years to re-detect it's location (LD Wedewer, PhD) Having normal to

> high testosterone levels actually reduce the risk of prostate cancer and can

> be cardioprotective (Bain, 2007; Mearini et al., 2008).

> Bruce Fife, N.D., says, " Every single one of us has cancerous cells in our

> bodies. As long as As long as the immune system is functioning in the

> manner for which it was designed, we need not worry about cancer. "

> " In other words, cancer can only develop in those individuals whose immune

> systems are so stressed or weakened that they are incapable of mounting an

> effective defense. Thus, a healthy immune system is a key element in the

> prevention of all forms of cancer, " he adds.

> The anti-viral effects of MCFA's (medium-chain fatty acids) in Extra

> virgin coconut oil has been studied, documented and proven by various

research

> groups here and in the US.

> Cancer can be caused by a number of factors such as free radicals and

> carcinogenic chemicals, the effects of which appear to be tempered by coconut

> oil.

> Other known causes are viruses. Human papillomavirus (HPV), for instance,

> is found in virtually every case of cervical cancer.

> Other viruses that may be linked to cancer include the Epstein-Barr virus,

> ytomegalovirus and adenovirus.

> Virgin coconut oil may be helpful in preventing these cancers because of

> MCFA's anti-viral effects.

> Researchers concluded that MCFA's enhance the immune system. A group of

> researchers tested these hypotheses and found that monolaurin, a

> monoglyceride of lauric acid, stimulates the production of white blood cells,

> specifically T cells which attack and kill anything that is foreign to the

body,

> including cancerous cells.

>

> Another study shows that MCFA's can influence the fatty acid composition

> of tumor tissue and tumor protein kinetics inhibiting tumor growth.

> Virgin Coconut oil can also cure skin cancer as proven in a study where

> Virgin Coconut oil is applied on the skin of mice which were applied with

> cancer causing chemicals. Several applications of Virgin Coconut oil stopped

> tumor development. Therefore, Virgin Coconut oil can alter the composition

> of tumor tissue and thus inhibit tumor growth.

> These pieces of evidence show that virgin coconut oil acts as a protective

> anti-oxidant that stops the destructive action and cancer-promoting effect

> of free radicals. It enhances the immune system, which actively fights

> renegade cells and blocks the uncontrolled growth of cancer cells against the

> mutagenic effects of carcinogens.

> Lauric acid-rich Extra Virgin Coconut oil takes over the task of

> destroying many of the invading microbes. And with less harmful organisms

around to

> cause trouble, the white blood cells of your immune system are free to

> search and destroy cancerous cells.

> Only other natural source for Lauric acid is Human breast milk, which

> provides a immune system to babies.

> Virgin Coconut oil can be used as a weapon to fight cancer and save

> precious lives. This statement is proven not only by numerous testimonies of

> cancer survivors but with the results of medical studies.

> Regular consumption of Virgin Coconut oil will strengthen the immune

> system. Only a strong immune system can defeat the formation of cancer cells

> before they can create major damage. Developing a strong immune system is the

> first step in prevention and treatment of cancer and other diseases.

> Pls visit Video on Virgin Coconut oil as treatment for Cancer : Researches

> on Animals

> _http://www.youtube.com/watch?v=hqNoPvESoc8_

> (http://www.youtube.com/watch?v=hqNoPvESoc8)

> _http://www.thevirgincoconutoil.com/articleitem.php?_

> (http://www.thevirgincoconutoil.com/articleitem.php?)

> _http://www.matrixvirgincoconutoil.com/page6.htm_

> (http://www.matrixvirgincoconutoil.com/page6.htm)

> Hawaiians call coconut water noelani (no-way lah-nee), which means “dew

> from the heavens.†Coconut water has a long history of use as both a food

and

> as a medicine.

> Coconut water contains a variety of nutrients including vitamins,

> minerals, antioxidants, amino acids, enzymes, growth factors, and other

> phytonutrients. Since coconuts are grown near the sea, the roots have access

to a

> continual supply of mineral rich salt water. These minerals are absorbed by

the

> roots and find their way into the fruit of the coconut. For this reason,

> coconut water is a good source of the major minerals like magnesium,

> calcium, and potassium. It is particularly rich in potassium, an essential

> nutrient; one 8-ounce cup of coconut water has more potassium than a banana.

It

> also contains a variety of trace elements such as zinc, selenium, iodine,

> sulfur, manganese, boron, molybdenum, and others. All derived from volcanic

> soils and seawater from which the coconut palms are grown. All of these

> minerals are in the form of electrolytes so they are easily absorbable by the

> human body. Many of the health benefits attributed to coconut water can be

> traced to its mineral content.

> The fat content of coconut water is so low it is essentially fat-free.

> Coconut water is relatively low in sugar compared to other fruit juices. It

> contains only a fifth of the sugar that you get from an equal amount of fresh

> grape or apple juice. Even though it is low in sugar, it has a mildly

> sweet, delightful taste, making it an excellent alternative to fruit juice

and

> sodas.

> In regulating cell growth, cytokinins also prevent mistakes that may lead

> to the development of cancer. Normal cells are kept healthy while cancerous

> cells are programmed to die, preventing them from growing and spreading.

> Much of the early research on cytokinins was funded by The American Cancer

> Society. Soon after the discovery of cytokinins in the 1950s researchers

> quickly recognized their potential in fighting cancer. Subsequently, the

> anti-cancer effects of cytokinins have been well documented.5-6 References

> 1. Macalalag, E.V. and Macalalag, A.L. Bukolysis: young coconut water

> renoclysis for urinary stone dissolution. Int Surg 1987;72:247.

> 2. Alleyne, T., et al. The control of hypertension by use of coconut water

> and mauby: two tropical food drinks. West Indian Med J 2005;54:3-8.

> 3. Shah, N.J., et al. Use of coco-nut water in treatment of congestive

> cardiac failure. Ind Jour Med Res 1956;44:341-351.

> 4. Rattan, S.I.S. and , B.F.C. Kinetin delays the onset of ageing

> characteristics in human fibroblasts. Biochem Biophys Res 1994;201:665-672.

> 5. Adair, W.L. and Brennan, S.L. The role of N-6-isopentenyl adenine in

> tumor cell growth. Biochem Biophys Res Commun 1986;137:208-214.

> 6. Dolezal, K, et al. Preparation and biological activity of

> 6-benzylaminopurine derivatives in plants and human cancer cells. Bioorg Med

Chem

> 2006;14:875-874.

> Coconut oil provides a quick and easy source of nutrition because of it is

> easily digested and aids assimilation of other nutrients. For this reason

> it has been recommended in the treatment of malnutrition (which can be a

> problem in a person suffering from pancreatic cancer). Coconut oil can help

> with fatigue and a whole range of conditions because its antimicrobial

> effects defeat organisms in the body, which may be draining the body's

strength

> and causative to the condition.

> COCO SAP AND CANCER. Administrator Garin likewise highlighted the

> potential of fresh coco sap or toddy which contains inositol in the

medication of

> cancer patients. “We have to develop a way of prolonging the shelf life of

> coco sap while maintaining its fresh and pure form, and the validation as

> well as of the health benefits through a clinical study,†he said.

> _http://www.mb.com.ph/node/233503/pca-urge_

> (http://www.mb.com.ph/node/233503/pca-urge)

> When Albert Schweitzer operated his clinic in tropical Africa, he said it

> was many years before he saw any cases of cancer, and he believed that the

> appearance of cancer was caused by the change to the European type of diet.

> In the l920s, German researchers showed that mice on a fat-free diet were

> practically free of cancer. Since then, many studies have demonstrated a

> very close association between consumption of unsaturated oils and the

> incidence of cancer. Heart damage is easily produced in animals by feeding

them

> linoleic acid; this " essential " fatty acid turned out to be the heart toxin

> in rape-seed oil.

> The addition of saturated fat to the experimental heart-toxic oil-rich

> diet protects against the damage to heart cells. Immunosuppression was

> observed in patients who were being " nourished " by intravenous emulsions of

> " essential fatty acids, " and as a result coconut oil is used as the basis for

> intravenous fat feeding, except in organ-transplant patients. For those

> patients, emulsions of unsaturated oils are used specifically for their

> immunosuppressive effects.

> General aging, and especially aging of the brain, is increasingly seen as

> being closely associated with lipid peroxidation. Several years ago I met

> an old couple, who were only a few years apart in age, but the wife looked

> many years younger than her doddering old husband. She was from the

> Philippines, and she remarked that she always had to cook two meals at the

same

> time, because her husband couldn't adapt to her traditional food. Three times

> every day, she still prepared her food in coconut oil. Her apparent youth

> increased my interest in the effects of coconut oil.

> But other researchers who were studying vitamin B6 recognized the

> condition as a deficiency of that vitamin. They were able to cause the

condition by

> feeding a fat-free diet, and to cure the condition by feeding a single B

> vitamin. The hypermetabolic animals simply needed a better diet than the

> " normal, " fat-fed, cancer-prone animals did. G. W. Crile and his wife found

> that the metabolic rate of people in Yucatan, where coconut is a staple food,

> averaged 25% higher than that of people in the United States. In a hot

> climate, the adaptive tendency is to have a lower metabolic rate, so it is

> clear that some factor is more than offsetting this expected effect of high

> environmental temperatures. The people there are lean, and recently it has

> been observed that the women there have none of the symptoms we commonly

> associate with the menopause

> However, in 1980, experimenters demonstrated that young rats fed milk

> containing soy oil incorporated the oil directly into their brain cells, and

> had structurally abnormal brain cells as a result. Lipid peroxidation occurs

> during seizures, and antioxidants such as vitamin E have some anti-seizure

> activity. Currently, lipid peroxidation is being found to be involved in

> the nerve cell degeneration of Alzheimer's disease. Various fractions of

> coconut oil are coming into use as " drugs, " meaning that they are advertised

as

> treatments for diseases. Butyric acid is used to treat cancer, lauric and

> myristic acids to treat virus infections, and mixtures of medium-chain fats

> are sold for weight loss. Purification undoubtedly increases certain

> effects, and results in profitable products, but in the absence of more

precise

> knowledge, I think the whole natural product, used as a regular food, is

> the best way to protect health.

> When people become interested in coconut oil as a " health food, " the huge

> seed-oil industry--operating through their shills--are going to attack it

> as an " unproved drug. " While components of coconut oil have been found to

> have remarkable physiological effects (as antihistamines,

> antiinfectives/antiseptics, promoters of immunity, glucocorticoid antagonist,

nontoxic

> anticancer agents, for example), I think it is important to avoid making any

such

> claims for the natural coconut oil, because it very easily could be banned

> from the import market as a " new drug " which isn't " approved by the FDA. "

> Now, it seems that the effect is just one more toxic action, in which the

> liver defensively retains its cholesterol, rather than releasing it into

> the blood. Large scale human studies have provided overwhelming evidence that

> whenever drugs, including the unsaturated oils, were used to lower serum

> cholesterol, mortality increased, from a variety of causes including

> accidents, but mainly from cancer. Since the l930s, it has been clearly

> established that suppression of the thyroid raises serum cholesterol (while

> increasing mortality from infections, cancer, and heart disease), while

restoring

> the thyroid hormone brings cholesterol down to normal. In this situation,

> however, thyroid isn't suppressing the synthesis of cholesterol, but rather

is

> promoting its use to form hormones and bile salts. When the thyroid is

> functioning properly, the amount of cholesterol in the blood entering the

> ovary governs the amount of progesterone being produced by the ovary, and the

> same situation exists in all steroid-forming tissues, such as the adrenal

> glands and the brain. Progesterone and its precursor, pregnenolone, have a

> generalized protective function: antioxidant, anti-seizure, antitoxin,

> anti-spasm, anti-clot, anti-cancer, pro-memory, pro-myelination,

pro-attention,

> etc.

> Any interference with the formation of cholesterol will interfere with all

> of these exceedingly important protective functions. As far as the

> evidence goes, it suggests that coconut oil, added regularly to a balanced

diet,

> lowers cholesterol to normal by promoting its conversion into pregnenolone.

> (The coconut family contains steroids that resemble pregnenolone, but these

> are probably mostly removed when the fresh oil is washed with water to

> remove the enzymes which would digest the oil.)

> Studies in Sri Lanka

>

> In 1989, a Sri Lankan study conducted by Prof. Shanti Mendis, using male

> participants showed that when coconut oil is replaced by corn oil, the total

> blood cholesterol, good (HDL) cholesterol and bad (LDL) cholesterol were

> similarly decreased. The study found however that consumption of coconut

> oil, raised both LDL and HDL, and also had the undesirable effect of raising

> the LDL to HDL ratio. Adding further to the complexity of the subject, Prof.

> Mendis also found in a subsequent study, that when coconut oil consumption

> is reduced and that amount is replaced with polyunsaturated oils such as

> sunflower or sesame oil, total cholesterol and bad cholesterol (LDL) can be

> reduced without reducing good cholesterol (HDL). It seems therefore, that

> coconut oil (saturated fat) raised both HDL and LDL, though not

> proportionally (the LDL: HDL is increased), while polyunsaturated oils

decrease both.

>

>

> The “buzz on the street†about coconut oil’s benefits is firmly grounded

> in science. Saturated fats in general enhance the immune system,3 and

> coconut oil in particular increases body temperature and is preferentially

used

> by the body for energy rather than storage.4 The claim about benefits to

> blood pressure is not one that I have ever made, and as far as I know, there

> are no human studies that have looked at the effect of coconut oil on blood

> pressure.

> The story is a report by Dr. Newport, a neonatologist and medical

> director of the newborn intensive care unit at Spring Hill Regional Hospital

> in Florida. About six years ago, her husband, an accountant who worked at

> home, began struggling with daily tasks. His deterioration progressed and he

> was eventually diagnosed with early onset Alzheimer’s. Dr. Newport searched

> the Internet for clinical drug trials that would accept her husband and

> discovered that a drug containing medium-chain triglycerides, the kind of fat

> in coconut oil, had achieved remarkable results†" not just slowing the

> progression of the disease but providing real improvement.

> She decided to give her husband coconut oil, two tablespoons per day, and

> her husband immediately improved, scoring 18 on a cognitive assessment, four

> points higher than he had scored the previous day. Within a week he showed

> tremendous improvement and five months later her husband was leading a

> relatively normal life, although still unable to resume his work as an

> accountant, apparently due to permanent brain damage.

> Coconut oil holds potential in the treatment of cancer as well, as several

> studies have indicated coconut oil’s anticarcinogenic effects.15

> Lim-Sylianco CY. Anticarcinogenic effect of coconut oil. The Philippine

> Journal of Coconut Studies 12:89-102;1987; Reddy BS, Maeura Y. Tumor

> promotion of dietary fat in azoxymethane-induced colon carcinogenesis in

female F

> 344 rats. Journal of the National Cancer Institute 72:745- 750;1984; Cohen

> LA and others. Dietary fat and mammary cancer. I. Promoting effects of

> different dietary fats on N-nitrosomethylurea-induced rat mammary

tumorigenesis.

> Journal of the National Cancer Institute 77:33;1986; Cohen LA and others.

> Dietary fat and mammary cancer. II. Modulation of serum and tumor lipid

> composition and tumor prostaglandins by different dietary fats: Association

> with tumor incidence patterns. Journal of the National Cancer Institute

> 77:43;1986.

> G. Enig, PhD is an expert of international renown in the field of

> lipid biochemistry. She has headed a number of studies on the content and

> effects of trans fatty acids in America and Israel, and has successfully

> challenged government assertions that dietary animal fat causes cancer and

heart

> disease. Recent scientific and media attention on the possible adverse

> health effects of trans fatty acids has brought increased attention to her

> work. She is a licensed nutritionist, certified by the Certification Board

for

> Nutrition Specialists, a qualified expert witness, nutrition consultant to

> individuals, industry and state and federal governments, contributing

> editor to a number of scientific publications, Fellow of the American College

of

> Nutrition and President of the land Nutritionists Association. She is

> the author of over 60 technical papers and presentations, as well as a

> popular lecturer. Dr. Enig is currently working on the exploratory

development

> of an adjunct therapy for AIDS using complete medium chain saturated fatty

> acids from whole foods. She is Vice-President of the Weston A Price

> Foundation and Scientific Editor of Wise Traditions as well as the author of

Know

> Your Fats: The Complete Primer for Understanding the Nutrition of Fats,

> Oils, and Cholesterol, Bethesda Press, May 2000. She is the mother of three

> healthy children brought up on whole foods including butter, cream, eggs and

> meat.

> Tocotrienols and stroke-induced Injuries

> In the peer-reviewed Stroke journal (Oct 2005), oral supplementation of a

> natural full spectrum palm tocotrienol complex to spontaneously

> hypertensive rats led to increased tocotrienols level in the brain. The rats,

> supplemented with tocotrienols, showed more protection against stroke-induced

> injury compared to controls (non-supplemented group). This study demonstrated

> that oral supplementation of the palm tocotrienol complex acts on key

> molecular checkpoints (c-Src and 12-Lipoxygenase) to protect against

glutamate-

> and stroke-induced neurodegeneration and ultimately protect against stroke in

> vivo._[37]_ (http://en.wikipedia.org/wiki/Tocotrienol#cite_note-36) The

> protective effects of tocotrienols are independent of their antioxidant

> activity because tocopherols were effective only at higher

concentrates._[38]_

> (http://en.wikipedia.org/wiki/Tocotrienol#cite_note-37)

> In 2005, a study jointly undertaken at Wayne State University and Ohio

> State University Medical Center show that tocotrienol can be efficiently

> delivered to organs and could therefore offer the health benefits suggested by

> in vitro and in vivo studies._[39]_

> (http://en.wikipedia.org/wiki/Tocotrienol#cite_note-38) " Our results

demonstrate that tocotrienols is efficiently

> delivered to the bloodstream despite the fact that the transfer protein has

> a lower affinity for tocotrienols than it has for tocopherols, " said

> Chandan Sen of Ohio State University and senior author of the study.[_cite

this

> quote_

> (http://en.wikipedia.org/wiki/Wikipedia:Quotations#How_to_use_quotations) ]

> The researchers recruited women with normal cholesterol levels (average age

> of 23.5 years old) and gave them a fat-rich strawberry smoothie containing

> 400 mg of vitamin E containing 77 mg alpha-tocotrienol, 96 mg

> delta-tocotrienol, and 3 mg gamma-tocotrienol, plus tocopherols. Since

vitamin E is a

> fat-soluble vitamin, the researchers chose to deliver the micronutrient in

> a fat-loaded meal in order to improve absorption. Blood measurements in the

> post-prandial period showed that maximal alpha-tocotrienol levels averaged

> almost 3 micromoles in blood plasma, 1.7 micromoles in low density

> lipoproteins, and 0.5 micromoles in high density lipoproteins. " This work

present

> first evidence demonstrating the post-absorptive fate of tocotrienol

> isomers and their association with lipoprotein subfractions in humans, " wrote

> lead author Pramod Khosla of Wayne State University.[_cite this quote_

> (http://en.wikipedia.org/wiki/Wikipedia:Quotations#How_to_use_quotations) ]

> These concentrations, say the researchers, are sufficient to support the

> proposed neuro-protective functions of tocotrienol. " We have determined that

> when administered orally, tocotrienol can reach concentrations needed to

> serve these… protective functions, " said Sen. " It is a regular dietary

> ingredient in Asia, so it can safely be a part of a daily diet within

prepared

> foods or as a supplement in the United States. " Can it be therapeutically

> used to prevent stroke? " Results from animal studies are encouraging, but it

> is still too soon to tell for humans, " he added.[_cite this quote_

> (http://en.wikipedia.org/wiki/Wikipedia:Quotations#How_to_use_quotations) ]

> [_edit_

> (http://en.wikipedia.org/w/index.php?title=Tocotrienol & action=edit & section=7)

] Tocotrienols and pancreatic cancer

> Pancreatic cancer represents the fourth-leading cause of cancer death in

> the United States, with a dismal 5-year survival rate of less than 5%. Early

> detection and screening for pancreatic cancer in the current state should

> be limited to high-risk patients, although hereditary/familial factors

> account for only 10% of patients with pancreatic cancer._[40]_

> (http://en.wikipedia.org/wiki/Tocotrienol#cite_note-39) _[41]_

> (http://en.wikipedia.org/wiki/Tocotrienol#cite_note-40)

> Tocotrienols are more effective antioxidants than tocopherols because its

> unsaturated _side chain_ (http://en.wikipedia.org/wiki/Side_chain)

> facilitate better penetration into saturated fatty layers of the _brain_

> (http://en.wikipedia.org/wiki/Brain) _[42]_

> (http://en.wikipedia.org/wiki/Tocotrienol#cite_note-41) and _liver_

(http://en.wikipedia.org/wiki/Liver) ._[43]_

> (http://en.wikipedia.org/wiki/Tocotrienol#cite_note-42) Tocotrienols can

> lower _tumor_ (http://en.wikipedia.org/wiki/Tumor) formation,_[44]_

> (http://en.wikipedia.org/wiki/Tocotrienol#cite_note-43) _DNA_

> (http://en.wikipedia.org/wiki/DNA) damage and _cell_

(http://en.wikipedia.org/wiki/Cell_(biology))

> damage._[45]_ (http://en.wikipedia.org/wiki/Tocotrienol#cite_note-44) In

> a 1993 study where rats were induced with potent liver cancer agent,

> scientists found less liver cell damage in the group fed with palm

> tocotrienols._[24]_

(http://en.wikipedia.org/wiki/Tocotrienol#cite_note-pmid19367124-23)

> _[46]_ (http://en.wikipedia.org/wiki/Tocotrienol#cite_note-45)

> In 2009, scientists at Department of Nutrition and Food Sciences, Texas

> Woman's University evaluated the impact of d-delta-tocotrienol, a potent

> vitamin E isomer, on human MIA PaCa-2 and PANC-1 pancreatic carcinoma cells

and

> BxPC-3 pancreatic ductal adenocarcinoma cells. They concluded suppression

> of mevalonate pathway activities, be it by modulators of HMG CoA reductase

> (statins, tocotrienols, and farnesol), farnesyl transferase (farnesyl

> transferase inhibitors), and/or mevalonate pyrophosphate decarboxylase

> (phenylacetate) activity, have a potential in pancreatic cancer

chemotherapy._[47]_

> (http://en.wikipedia.org/wiki/Tocotrienol#cite_note-46) Moreover, a Phase

> I dose-escalating study evaluating the effect of a pure Tocotrienol delta

> isomer extracted from palm oil towards individuals with Pancreatic cancer is

> currently underway at the Moffitt Cancer Centre, and is the first time

> tocotrienol has been clinically evaluated in humans towards cancer._[48]_

> (http://en.wikipedia.org/wiki/Tocotrienol#cite_note-47)

> [_edit_

> (http://en.wikipedia.org/w/index.php?title=Tocotrienol & action=edit & section=8)

] Tocotrienols and breast cancer

> In the 1990s, studies showed tocotrienols are the components of vitamin E

> responsible for growth inhibition in human _breast cancer_

> (http://en.wikipedia.org/wiki/Breast_cancer) cells _in vitro_

> (http://en.wikipedia.org/wiki/In_vitro) ,_[49]_

(http://en.wikipedia.org/wiki/Tocotrienol#cite_note-48)

> through estrogen-independent mechanisms._[50]_

> (http://en.wikipedia.org/wiki/Tocotrienol#cite_note-49) Tocotrienols work

synergistically with

> tamoxifen, a commonly used breast cancer medicine, in killing cancer

cells._[51]_

> (http://en.wikipedia.org/wiki/Tocotrienol#cite_note-50)

> Tocotrienols can also affect cell _homeostasis_

> (http://en.wikipedia.org/wiki/Homeostasis) , possibly independently of their

antioxidant

> activity._[52]_ (http://en.wikipedia.org/wiki/Tocotrienol#cite_note-51)

Anti-cancer

> effects of α- and γ-tocotrienol have been reported, although δ-tocotrienol

was

> verified to be the most effective tocotrienol in inducing _apoptosis_

> (http://en.wikipedia.org/wiki/Apoptosis) _[53]_

> (http://en.wikipedia.org/wiki/Tocotrienol#cite_note-52) (cell death) in

estrogen-responsive and

> estrogen-nonresponsive human breast cancer cells. Based on these results on

cells in

> culture, investigators have hypothesised that a mixture of α- and γ

> -tocotrienols might reduce breast cancer risk._[54]_

> (http://en.wikipedia.org/wiki/Tocotrienol#cite_note-53)

> Further studies on tocotrienol and breast cancer indicated that

> gamma-tocotrienol targets cancer cells by inhibiting Id1, a key

cancer-promoting

> protein. Gamma-tocotrienol was shown to trigger cell apoptosis and well as

> anti-proliferation of cancer cells. This mechanism was also observed in

> separate prostate cancer and melanoma cell line studies_[55]_

> (http://en.wikipedia.org/wiki/Tocotrienol#cite_note-54) .

> In 2009, a study by scientists at the College of Pharmacy, University of

> Louisiana at Monroe showed statins and tocotrienols provide significant

> health benefits in the treatment of breast cancer in women, while avoiding

> myotoxicity associated with high dose statin monotherapy._[56]_

> (http://en.wikipedia.org/wiki/Tocotrienol#cite_note-55)

> [_edit_

> (http://en.wikipedia.org/w/index.php?title=Tocotrienol & action=edit & section=9)

] Tocotrienols and prostate cancer

> Investigation of the _antiproliferative_

> (http://en.wikipedia.org/wiki/Antiproliferative) effect of tocotrienols in

PC3 and LNCaP _prostate cancer_

> (http://en.wikipedia.org/wiki/Prostate_cancer) cells suggests that the

> transformation of vitamin E to CEHC is mostly a _detoxification_

> (http://en.wikipedia.org/wiki/Detoxification) mechanism, useful to maintain

the malignant

> properties of prostate cancer cells._[57]_

> (http://en.wikipedia.org/wiki/Tocotrienol#cite_note-56) However, recent

research suggested that γ

> -tocotrienol was most potent in suppressing prostate cancer cell

proliferation, and

> that the antiproliferative effect of γ-tocotrienol act through

> multiple-signalling pathways (NF-B, EGF-R and Id family proteins). In

addition, the

> same study demonstrated the anti-invasion and chemosensitisation effect of γ

> -tocotrienol against PCa cells._[58]_

> (http://en.wikipedia.org/wiki/Tocotrienol#cite_note-57)

> [_edit_

> (http://en.wikipedia.org/w/index.php?title=Tocotrienol & action=edit & section=10)

] Tocotrienols and skin cancer

> In a 2009 study at the Li Ka Shing Faculty of Medicine, The University of

> Hong Kong, scientists found reduction in skin cancer cells when treated with

> gamma-tocotrienol with chemotherapy drugs. For the first time,

> researchers recorded the anti-invasion and chemonsensitization effect of

> gamma-tocotrienol against human malignant melanoma cells._[59]_

> (http://en.wikipedia.org/wiki/Tocotrienol#cite_note-58)

> [_edit_

> (http://en.wikipedia.org/w/index.php?title=Tocotrienol & action=edit & section=11)

] Tocotrienols and cholesterol reduction

> The human body makes cholesterol from the liver, producing about 1g of

> _cholesterol_ (http://en.wikipedia.org/wiki/Cholesterol) each day or 80% of

the

> needed total body cholesterol. The remaining 20% comes from what we eat.

> Excessive cholesterol is a health risk because gradual fatty deposit clog up

> the arteries. This will cause blood flow to the brain, heart, kidneys and

> other parts of the body become less efficient.

> _Cholesterol_ (http://en.wikipedia.org/wiki/Cholesterol) , though needed

> metabolically, is not essential in diet. Tocotrienols can decrease the

> liver's capacity to manufacture cholesterol. It does so by suppressing the

> HMG-CoA reductase, the enzyme in the liver responsible for cholesterol

> synthesis._[20]_

(http://en.wikipedia.org/wiki/Tocotrienol#cite_note-pmid8388388-19)

> In 1993, American scientists conducted a double-blind placebo controlled

> study of 50 volunteers at the Jordan Heart Foundation and Elmhurst

> Medical Center. Their results suggested that palm tocotrienols could ease

> clogged arteries. Seven high cholesterol patients with narrowing arteries

> experienced reverse arterial blockage of the carotid artery after consuming

> palm tocotrienols, while in two the conditioned worsened._[16]_

>

(http://en.wikipedia.org/wiki/Tocotrienol#cite_note-Tomeo_AC.2C_Geller_M.2C_Watk\

ins_TR.2C_G

> apor_A.2C_Bierenbaum_ML_1995_1179.E2.80.9383-15) This compared to the

> control group, where none improved and ten worsened.

> Tocotrienols, especially δ- and γ-tocotrienols, were shown to be effective

> nutritional agents in treating high cholesterol. In particular, γ

> -tocotrienol appears to act on a specific _enzyme_

> (http://en.wikipedia.org/wiki/Enzyme) called

3-hydroxy-3-methylglutaryl-coenzyme and suppresses the

> production of this enzyme, resulting in less cholesterol being manufactured

by

> liver cells._[60]_ (http://en.wikipedia.org/wiki/Tocotrienol#cite_note-59)

> While a 1995 study in chickens indicated that the presence of dietary

> alpha-tocopherol may interfere with tocotrienol's ability to lower

cholesterol

> _[61]_ (http://en.wikipedia.org/wiki/Tocotrienol#cite_note-60) although a

> later study found the interference was seen towards alpha-tocotrienol

> only._[62]_ (http://en.wikipedia.org/wiki/Tocotrienol#cite_note-61)

> [_edit_

> (http://en.wikipedia.org/w/index.php?title=Tocotrienol & action=edit & section=12)

] Tocotrienols and diabetes

> According to the World Health Organization (WHO), 170 million people were

> affected by diabetes in the year 2002, and this number is likely to increase

> to 366 million by the year 2030._[63]_

> (http://en.wikipedia.org/wiki/Tocotrienol#cite_note-62) Diabetes mellitus

(DM) has been recognized as the

> sole independent risk factor for the development of any cardiovascular

> disease._[64]_ (http://en.wikipedia.org/wiki/Tocotrienol#cite_note-63)

> Cardiovascular complications include stroke and heart attack, are

increasingly causing

> death in diabetic patients. Alarmingly, literature statistics indicate

> that atherosclerosis accounts for about 8 to 10% of all diabetic

deaths._[65]_

> (http://en.wikipedia.org/wiki/Tocotrienol#cite_note-64)

> Recent studies are showing that vitamin E intake significantly reduce risk

> of type 2 diabetes. The relative risk (RR) of type 2 diabetes between the

> extreme quartiles of the intake was 0.69 (95% CI 0.51-0.94, P for

> trend=0.003). Intakes of alpha-tocopherol, gamma-tocopherol,

delta-tocopherol, and

> beta-tocotrienol were inversely related to a risk of type 2 _diabetes_

> (http://en.wikipedia.org/wiki/Diabetes) . While _correlation does not imply

> causation_ (http://en.wikipedia.org/wiki/Correlation_does_not_imply_causation)

,

> these data suggest the possibility that the development of type 2 diabetes

> might be modified by the intake of antioxidants in the diet._[66]_

> (http://en.wikipedia.org/wiki/Tocotrienol#cite_note-65)

> In 2009, animal trials carried out in India and Malaysia revealed palm

> tocotrienols improved blood glucose, dyslipidemia and oxidative stress in

> diabetic rats. It is able to prevent the progression of vascular wall changes

> occurring in DM._[67]_

> (http://en.wikipedia.org/wiki/Tocotrienol#cite_note-66) _[68]_

(http://en.wikipedia.org/wiki/Tocotrienol#cite_note-67)

> [_edit_

> (http://en.wikipedia.org/w/index.php?title=Tocotrienol & action=edit & section=13)

] No-observed-adverse-effect level

> A 13-week study by H. Nakamura and colleagues at the _National Institute of

> Health Sciences (Japan)_

>

(http://en.wikipedia.org/w/index.php?title=National_Institute_of_Health_Sciences\

_(Japan) & action=edit & redlink=1) of

> tocotrienols' toxicity in rats found significant changes in several blood

> components, increases in liver weights and (in females) reductions in ovary

and

> uterus weights, depending on the dosages. The authors estimated the

> no-observed-adverse-effect level (NOAEL) to be 120 mg per kg of body weight

per day for

> males and 130 mg per kg of body weight per day for females. Since effects

> on the blood components were observed in all cases with non-placebos, a

> no-observed-effect level (NOEL) could not be determined._[35]_

> (http://en.wikipedia.org/wiki/Tocotrienol#cite_note-rats_lose_red_cells-34)

> [_edit_

> (http://en.wikipedia.org/w/index.php?title=Tocotrienol & action=edit & section=14)

] See also

> * _Lycopene_ (http://en.wikipedia.org/wiki/Lycopene)

> [_edit_

> (http://en.wikipedia.org/w/index.php?title=Tocotrienol & action=edit & section=15)

] References

>

> 1. _^_ (http://en.wikipedia.org/wiki/Tocotrienol#cite_ref-0) Whittle

> KJ, Dunphy PJ, Pennock JF (July 1966). _ " The isolation and properties of

> delta-tocotrienol from Hevea latex " _

>

(http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez & artid=126510\

4) . The Biochemical Journal 100

> (1): 138†" 45. _PMID_ (http://en.wikipedia.org/wiki/PubMed_Identifier)

> _5965249_ (http://www.ncbi.nlm.nih.gov/pubmed/5965249) .

> 2. _^_ (http://en.wikipedia.org/wiki/Tocotrienol#cite_ref-1)

> Brigelius-Flohé R, Traber MG (July 1999). _ " Vitamin E: function and

metabolism " _

> (http://www.fasebj.org/cgi/pmidlookup?view=long & pmid=10385606) . The FASEB

> Journal 13 (10): 1145†" 55. _PMID_

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(http://www.ncbi.nlm.nih.gov/pubmed/10385606) .

> _http://www.fasebj.org/cgi/pmidlookup?view=long & pmid=10385606_

> (http://www.fasebj.org/cgi/pmidlookup?view=long & pmid=10385606) .

> 3. _^_ (http://en.wikipedia.org/wiki/Tocotrienol#cite_ref-2)

> Cerecetto H, López GV (March 2007). " Antioxidants derived from vitamin E: an

> overview " . Mini Reviews in Medicinal Chemistry 7 (3): 315†" 38. _doi_

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:_10.2174/138955707780059871_

> (http://dx.doi.org/10.2174/138955707780059871) . _PMID_

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> 4. _^_ (http://en.wikipedia.org/wiki/Tocotrienol#cite_ref-3) _Vitamin

> E in health and disease._

>

(http://books.google.com.my/books?id=s5LmBwSwwGsC & pg=PA3 & lpg=PA3 & dq=richest+sour\

ce+of+tocotrienols+palm+oil & source=bl & ots=47Nn

> ylIw7B & sig=BF4B3tnPSkNKCdCFz7PKn1TSYoo & hl=en & ei=EnKrSvDXBZHU

>

tgPa6_3_BA & sa=X & oi=book_result & ct=result & resnum=4#v=onepage & q=richest%20source%2\

0of%20tocotr

> ienols%20palm%20oil & f=false) By Lester Packer, Jürgen Fuchs, 1993

> 5. _^_ (http://en.wikipedia.org/wiki/Tocotrienol#cite_ref-4) Sen CK,

> Khanna S, Roy S (2007). _ " Tocotrienols in health and disease: the other

> half of the natural vitamin E family " _ (http://www.pubmedcentral

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of Medicine

> 28 (5-6): 692†" 728. _doi_

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> 7. _^_ (http://en.wikipedia.org/wiki/Tocotrienol#cite_ref-6) e

> MW, Burnett JR, Croft KD (2008). " Vitamin E in human health and disease " .

> Critical Reviews in Clinical Laboratory Sciences 45 (5): 417†" 50. _doi_

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> :_10.1080/10408360802118625_ (http://dx.doi.org/10.1080/10408360802118625) .

_PMID_

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> 8. _^_ (http://en.wikipedia.org/wiki/Tocotrienol#cite_ref-7) Dunphy,

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> " Identification and Estimation of Tocotrienols in Hevea Latex " . Nature 207:

521. _doi_

> (http://en.wikipedia.org/wiki/Digital_object_identifier) :_10.1038/207521a0_

> (http://dx.doi.org/10.1038/207521a0) .

> 9. _^_ (http://en.wikipedia.org/wiki/Tocotrienol#cite_ref-8)

> _Tocotrienols: Vitamin E Beyond Tocopherols_

>

(http://books.google.com.my/books?id=iKhwauCsj_kC & pg=PA6 & lpg=PA6 & dq=discover+toc\

otrienols & source=bl & ots=JkfyQUsMgk &

> sig=Prhdcok8I_o7OImHML3tC1ZJtpY & hl=en & ei=Dl2rSuvsNoKsswP6-5iEBQ & sa=X & oi=book

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> 10. _^_ (http://en.wikipedia.org/wiki/Tocotrienol#cite_ref-9) Tan, B.

> and M.H. Saleh, Integrated process for recovery of carotenoids and

> tocotrienols from oil in USPTO 5,157,132. 1992

> 11. _^_ (http://en.wikipedia.org/wiki/Tocotrienol#cite_ref-10)

> _tto_ (http://en.wikipedia.org/wiki/tto)

> 12. _^_ (http://en.wikipedia.org/wiki/Tocotrienol#cite_ref-11)

> Qureshi, A.A., Tocopherol attenuates the impact of gamma-tocotrienol on

HMG-CoA

> reductase activity in chickens. J Nutr, 1996. 126: p. 389-394

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> L, Weber SU, Rimbach G (February 2001). _ " Molecular aspects of

> alpha-tocotrienol antioxidant action and cell signalling " _

> (http://jn.nutrition.org/cgi/pmidlookup?view=long & pmid=11160563) . The Journal

of Nutrition 131 (2):

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content

> of the average Finnish diet " . International Journal for Vitamin and

> Nutrition Research 61 (1): 27†" 32. _PMID_

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> Khor HT, Low WH, Ali A, Gapor A (April 1991). _ " Effect of a

> palm-oil-vitamin E concentrate on the serum and lipoprotein lipids in

humans " _

> (http://www.ajcn.org/cgi/pmidlookup?view=long & pmid=2012011) . The American

Journal of

> Clinical Nutrition 53 (4 Suppl): 1027S†" 1030S. _PMID_

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> 16. ^ _a_

>

(http://en.wikipedia.org/wiki/Tocotrienol#cite_ref-Tomeo_AC.2C_Geller_M.2C_Watki\

ns_TR.2C_Gapor_A.2C_Bierenbaum_ML_1995_1179.E2.80.9383_15

> -0) _b_

>

(http://en.wikipedia.org/wiki/Tocotrienol#cite_ref-Tomeo_AC.2C_Geller_M.2C_Watki\

ns_TR.2C_Gapor_A.2C_Bierenbaum_ML_1995_1179.E2.80.9383_15-1)

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> " Antioxidant effects of tocotrienols in patients with hyperlipidemia and

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> (http://dx.doi.org/10.1007/BF02536621) . _PMID_

(http://en.wikipedia.org/wiki/PubMed_Identifier)

> _8614310_ (http://www.ncbi.nlm.nih.gov/pubmed/8614310) .

> 17. _^_ (http://en.wikipedia.org/wiki/Tocotrienol#cite_ref-16) Liu,

> Donghong; Shi, ; Posada, Luidy ; Kakuda, Yukio; Xue, Sophia Jun

> (2008). " Separating Tocotrienols from Palm Oil by Molecular Distillation " .

> Food Reviews International 24: 376. _doi_

> (http://en.wikipedia.org/wiki/Digital_object_identifier)

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> 18. _^_ (http://en.wikipedia.org/wiki/Tocotrienol#cite_ref-17) Sen CK,

> Khanna S, Roy S (March 2006). _ " Tocotrienols: Vitamin E beyond

> tocopherols " _

>

(http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez & artid=179086\

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