Guest guest Posted September 10, 2000 Report Share Posted September 10, 2000 Hi, , I don't know that anyone has measured both blood and antracellular glutathione - the only tests on glutathione levels that I know of is functional. Trying to play with ion levels to increase the cellular ion gradient isn't something that is possible. Even attemptingto push too much can lead to really bad things as ion levels go out of whack. The ion gradient is key to so many body processes - chemical energy production, nerve conduction, muscle contraction, nutrient uptake, cell signalling - basically every active process in the body relies on ion gradients. The " resting potential " - how much of an ion gradient there is - is pretty much fixed by the nature of the cell. It can get lower, like if the energy metabolism of the cell is poor, but can't go above a certain level. It could be that intracellular glutathione is being depleted very fast, but it would have to be ten times as fast as normal or something like that to get this level of an effect. A transport block makes more sense biochemically IMO. Also if whey & /or MSM help you, that suggests that increased _intracellular_ glutathione synthesis is having a benefit - the individual cells have the basic nutrients needed and the stimulus to make it rather than rely on liver synthesis. I haven't seen any data that magnets affect cellular ion gradients; I would be very surprised, since it is controlled by multiple feedback loops to stay in a particular range. It is possiblel that a virus could block the glutathione receptor; all viruses use one cell surface receptor or another to latch onto the cell to infect it. And;, just because your ANA, RA & whatever other autoimmune antibody tests came back negative doesn't mean that you don't have them. It just means that you don't have any that show up in those particular tests. Jerry >Thanks, I wasn't aware of this mechanism. Is this >feature of high blood glutathione a common finding in >PWCs? This is consistent with my experience that oral >reduced glutathione did nothing but MSM and immunepro >help, somehow enhancing intracellular uptake of >glutathione. I have read that MSM increases cell >membrame permiability but can't reference this. From >what you have said it seems that glutathione/ATP >should help, what about supplementing elecrolytes to >increase the ion gradient? This is alternative >medicine but there are wrist magnets marketed that are >claimed to enhance the ion gradient, the company also >sell colloidal minerals which are reported to enhancethe effect. >I have no autoimmune antibodies so that leaves us with >an intracellular pathogen. Rather than the pathogen >inhibiting the receptor proteins could it not just be >that it is depleting intracellular glutathione at anincredable rate? > >>Low functionality and high blood levels are the >>typical result of a problem in getting the nutrient >>from the bloodstream into cells. Blood levels keep >>going up as the body tries to get the intracellular >>concentration up, but it doesn't go up enough to >>reach good functional levels. There are typically >>specific receptor proteins that grab specific >>nutrients from the bloodstream and push them across >>the membrane (which requires ATP or equivalent energy >>from some ionn gradient, usually sodium or potassium.) _________________________________________________________________________ Get Your Private, Free E-mail from MSN Hotmail at http://www.hotmail.com. Share information about yourself, create your own public profile at http://profiles.msn.com. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 15, 2009 Report Share Posted May 15, 2009 Sorry wrong link; use the fifth link for Paris Kidd's Glutathione review: http://tinyurl.com/glutathione-references Duncan > > > > Duncan: > > I get weekly glutation shots of 100 mg from a little bottle at the doctors office. He relates that he doesn't know what else is in the bottle. My guess is preservative. Would I be better off trying to maintain my glutation levels with denatured protein. > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > Duke > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 16, 2009 Report Share Posted May 16, 2009 can't you increase glutathione with N-acetyl cysteine (NAC) instead of whey? i ask because NAC is much cheaper. On Fri, May 15, 2009 at 10:14 AM, Duncan Crow <duncancrow@...> wrote: > > > Sorry wrong link; use the fifth link for Paris Kidd's Glutathione review: > http://tinyurl.com/glutathione-references > > Duncan > > > > > > > > Duncan: > > > I get weekly glutation shots of 100 mg from a little bottle at the > doctors office. He relates that he doesn't know what else is in the bottle. > My guess is preservative. Would I be better off trying to maintain my > glutation levels with denatured protein. > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > Duke > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 16, 2009 Report Share Posted May 16, 2009 Jena, whey's glutathione increase lasts up to 8 times as long as that obtained by NAC so you don't have to dose as often. In a word, no, NAC is not really an adequate substitute; some cells don't use NAC or cystine but cysteine peptides and glutathione itself. Whey contains cystine and cysteine peptides. I found this info in a search on " cysteine toxicity " a couple of years ago: Since free cysteine is poorly absorbed and transported, and also toxic (Meister, 1984; Gutman and Schettini, 1998; Baruchel et al, 1996) and is spontaneously oxidized (Gutman and Schettini, 1998; Baruchel et al, 1996) it does not represent an ideal delivery system (Bounous et al, 1989; Gutman and Schettini, 1998). NAC is a cysteine molecule wrapped in vinegar molecules. Because of its rapid uptake and hydrolysis, it must be taken ideally every couple of hours or so; a hospital would probably do it every 4-5 hours. A decent oral dosage of 500-600 mg each time may encourage toxic side effects that can include headaches, dizziness and blurred vision; this would interfere with its use as a health supplement and the research doesn't portray it as one. NAC molecules are hydrolyzed in the stomach but not destroyed by stomach acid. Hydrolyzed means dissolution with water. Whatever stomach action may occur during that time may well dump some of it into the duodenum. During all this time whatever might get into the blood is still of course hydrolyzing on its way to the liver because it's still exposed to water. Finally, the fraction that remains enters the liver, and it's still being hydrolyzed, in fact until it enters a cell. Not so useful, dosewise, and that's why it causes toxicity. Duncan > > > > > > > > Duncan: > > > > I get weekly glutation shots of 100 mg from a little bottle at the > > doctors office. He relates that he doesn't know what else is in the bottle. > > My guess is preservative. Would I be better off trying to maintain my > > glutation levels with denatured protein. > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > Duke > > > > > > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
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