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Vecuronium

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Vecuronium Systematic

Chemical data: FormulaC34H57N2O4+, Mol. mass557.827 g/mol

Pharmacokinetic data:

Bioavailability100% (IV)

Metabolismliver 30%

Half life51–80 minutes (longer with renal failure)

ExcretionFecal (40-75%) and renal (30% as unchanged drug and metabolites)

Therapeutic considerations: Pregnancy cat.C(US)

Legal status

Routes: Intravenous

Vecuronium bromide (trade name Norcuron) is a muscle relaxant in the category of

non depolarising neuromuscular blocking agents. Vecuronium bromide is indicated

as an adjunct to general anesthesia, to facilitate endotracheal intubation and

to provide skeletal muscle relaxation during surgery or mechanical ventilation.

Although vecuronium bromide is often thought of as a muscle relaxant, it may be

more accurate to classify it as a paralyzing agent.

[edit] Clinical pharmacology

Vecuronium operates by competing for the cholinergic receptors at the motor end

plate thereby exerting its muscle relaxing properties which are used

adjunctively to general anesthesia. Under balanced anesthesia, the time to

recovery to 25% of control (clinical duration) is approximately 25 to 40 minutes

after injection and recovery is usually 95% complete approximately 45 to 65

minutes after injection of intubating dose. The neuromuscular blocking action of

vecuronium is slightly enhanced in the presence of potent inhalation

anesthetics. If vecuronium is first administered more than 5 minutes after the

start of the inhalation of enflurane, isoflurane, or halothane, or when steady

state has been achieved, the intubating dose of vecuronium may be decreased by

approximately 15%.

Vecuronium is normally given at 0.08–0.1 mg/kg intravenously and its

maintenance dose is usually between 0.02–0.03 mg/kg, but as with all other

neuromuscular blocking agents, the doses need to be tailored for each individual

patient.

[edit] See also

Pancuronium

[hide] v • d • eMuscle relaxants (M03)

Peripherally acting (primarily antinicotinic,

neuromuscular-blocking drugs)curare alkaloids (Alcuronium, Dimethyltubocurarine,

Tubocurarine) - choline derivatives (Suxamethonium) - other quaternary ammonium

compounds (Atracurium, Cisatracurium, Doxacurium chloride, Fazadinium bromide,

Gallamine, Hexafluronium, Mivacurium chloride, Pancuronium, Pipecuronium

bromide, Rocuronium bromide, Vecuronium) - other (Botulinum toxin)

Centrally actingcarbamic acid esters (Phenprobamate, Carisoprodol,

Methocarbamol, Styramate, Febarbamate), Baclofen, Chlormezanone, Chlorzoxazone,

Cyclobenzaprine, Lorazepam, Mephenesin, Orphenadrine, Phenyramidol, Pridinol,

Tetrazepam, Thiocolchicoside, Tizanidine, Tolperisone

Directly actingDantrolene

The above has been trunkated and edited by Jeanetta Mastron