Guest guest Posted November 15, 2004 Report Share Posted November 15, 2004 Hi , This is information abt cytochrome P450 according to my knowledge.PLZ TEXEXPERTS AND JEANETTE CHECK WHETHER IT IS CORRECT. The drug once in enters the body undergoes absorption,distribution and then excretion.For the process of excretion the drug has to undergo metabolism so that it gets converted into a form that is easily excreted in the urine.The process of metabolism takes place in many different ways.One of which is oxidation which takes place mostly in liver and this process is catalysed by group of enzymes called cytochrome P450.They help in the metabolism of many different drugs.After metabolism the oxidised product has increased polarity which increases the water solubilty and helps in its excretion in urine. Thanks hemali On Tue, 16 Nov 2004 hchaides wrote : > > >Can someone help me define cytochrome p450 in terms that are >understandable? I have searched the web trying to understand what >this means and I can not find a good answer. Any help? > >Thanks > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 15, 2004 Report Share Posted November 15, 2004 Hi Hemali and , I am not a texpert, but my definition of enzymes (example: Cytochrome P450), is of complex proteins that are capable of inducing chemical changes in other substances without being changed themselves. Multiple chemical reactions using specific enzymes occur throughout the body that causes a reaction to or not to occur. In the case of the liver, metabolism or biotransformation of drugs is the breakdown of a drug through chemical reactions to other less harmful substances. As Hermali indicated this is generally done to make substances more water soluble for easy excretion in the kidney. Cytochrome P-450 is just one of many active enzymes used by the liver in the formation of metabolites. The reason this particular enzyme is highlighted is mainly due to its abundance and potential drug-drug interactions this enzyme causes. As indicated, I am not a texpert and this may have to be reviewed by such. This is basically my personal understanding. Respectfully, Joe Medina, CPhT From: Tech Lectures Section I - How Do Drugs Work Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 16, 2004 Report Share Posted November 16, 2004 Nice job Hemali! I would say this: a drug needs to go through absorption, distribution, metabolism and then excretion. As Joe pointed out already; another word for metabolism is biotransformation, which simply means changed in the body. (watch your spelling of metabolism, metabolized etc) CPY450 is the nick name for cytochrome P450, which is just one of the many enzymes in the liver that chemically breakdown other substances in the body. And again all for the reasons that Joe pointed out. However I shall add more at an 'entry level': Let us suppose that a drug " A " enters the body and its purpose is to alleviate a non- migraine headache. It is VERY possible that the drug " A " will not actually do the " work " at all!!! Perhaps the drug will make a 'pass' through the liver and be 'changed' (metabolized)in to its metabolites drug " B " and drug " C " . It is possible that the enzyme CYP450 is responsible for the chemical change, and that drug " B " will do the work, while drug " C " will continue through the digestive tract to the 'outsied' of the body as an inactive substance. Of course as you pointed out water soluable to leave the body. Now drug " B " continues to do the work untilit passes again therough the liver to become drug " d " which may or may not continue the drug action to alleviate the headache. If it does so be it. If it does not then it too must be 'chemically brokendown " or changed into some substance that the body can not use and is water soluable. This is of course simplified but an easy way to understand 'metabolites', what they do and how we get rid of them. So in essence the drugs B, C and or D are all metabolites. One of the drugs on the market that interferes with CYP450 or vice versa is cimetidine (Tagamet) and many many drugs have interactions with it or shall we say it interferes with many drugs. It has more drug interactions than any other drug on the market. Okay I hope this helps also, Respectfully, Jeanetta Mastron CPhT BSChem PT Educator Founder/Owner > Hi , > This is information abt cytochrome P450 according to my knowledge.PLZ TEXEXPERTS AND JEANETTE CHECK WHETHER IT IS CORRECT. > The drug once in enters the body undergoes absorption,distribution and then excretion.For the process of excretion the drug has to undergo metabolism so that it gets converted into a form that is easily excreted in the urine.The process of metabolism takes place in many different ways.One of which is oxidation which takes place mostly in liver and this process is catalysed by group of enzymes called cytochrome P450.They help in the metabolism of many different drugs.After metabolism the oxidised product has increased polarity which increases the water solubilty and helps in its excretion in urine. > Thanks > hemali > > On Tue, 16 Nov 2004 hchaides wrote : > > > > > >Can someone help me define cytochrome p450 in terms that are > >understandable? I have searched the web trying to understand what > >this means and I can not find a good answer. Any help? > > > >Thanks > > > Quote Link to comment Share on other sites More sharing options...
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