Re: Antiemetic drugs

[Guest guest]

Dear Jay62201,

An excellent question!

This drug however is dependant upon the metabolism of the drug in the

liver (hepatic).

Additionally it is used MORE in prevention of N/V than in treatment of

it. Below you will find some information that I copied and pasted from

the internet:

http://www.emend.com/aprepitant/emend/index.jsp

EMEND, in combination with other antiemetic agents, is indicated for

prevention of:

· Acute and delayed nausea and vomiting associated with initial and

repeat courses of highly emetogenic cancer chemotherapy, including

high-dose cisplatin.

· Nausea and vomiting associated with initial and repeat courses of

moderately emetogenic cancer chemotherapy.

EMEND is indicated for prevention of:

· Postoperative nausea and vomiting.

Please NOTE the following which addresses YOUR question directly:

" " The effect of EMEND on the pharmacokinetics of orally administered

CYP3A4 substrates is greater than the effect of EMEND on the

pharmacokinetics of intravenously administered CYP3A4 substrates. " "

" " For chemotherapy-induced nausea and vomiting, EMEND is given for 3

days as part of a regimen that includes a corticosteroid and a 5-HT3

receptor antagonist. The recommended dosage of EMEND is 125 mg orally

1 hour BEFORE chemotherapy treatment (Day 1) and 80 mg once daily in

the morning on Days 2 and 3.

For postoperative nausea and vomiting, the recommended oral dosage of

EMEND is 40 mg within 3 hours BEFORE induction of anesthesia. " " "

You are correct that many drugs by pass the oral route to treat N/V

whenthe pt is experiencing N/V. N/V caused by chemotherapy is harder

to treat and therefore prevention is a better method.

I hope that this answers your specific question and needs.

Please feel free to ask further questions on this or other topics.

Respectfully,

Jeanetta Mastron CPhT BS Chemistry

Founder/Owner

>

> do all antiemetic drugs come in PO or IV???

> or should i say which is more common dosage form???

>

> this question revolves around an new drug Emend that is antiemetic use

> for postoperative nausea and vomiting

> since its post-op wouldn't it be IV????

>

[Guest guest]

Dear All,

Today I learned that this was posted by one of my recent graduates. He. Jay,

is a high school graduate as well. I think this is a very astute observation

for one who just recdently graduated. Yet there are other mechanisms of action

to consider that the new student is not aware of such as prophylactic purpose

for post operative nausea instead of treating it as it happens. I would not

expect a new graduate to know this.

I was very proud to learn it was one of my own students.

For those just tuning in: I have answered this technically in a previous post.

Jeanetta

jay62201 <gundam9187@...> wrote:

do all antiemetic drugs come in PO or IV???

or should i say which is more common dosage form???

this question revolves around an new drug Emend that is antiemetic use

for postoperative nausea and vomiting

since its post-op wouldn't it be IV????

[Guest guest]

Hi Jay,

Don't forget PR as a route of administration for antiemetics.

As to your question, I would say in a retail setting, we dispense more PO

antiemetics than any others.

--

Life should not be a journey to the grave with the intention of arriving safely

in an attractive and well-preserved body, but rather to skid in sideways,

champagne in one hand, strawberries in the other, body thoroughly used up,

totally worn out and screaming " WOO HOO - what a ride! "

-------------- Original message --------------

From: " jay62201 " <gundam9187@...>

do all antiemetic drugs come in PO or IV???

or should i say which is more common dosage form???

this question revolves around an new drug Emend that is antiemetic use

for postoperative nausea and vomiting

since its post-op wouldn't it be IV????

[Guest guest]

Good input .

In the Hospital setting antiemetics are given as rectal suppository and IV

mainly.

Back to Emend:

Emend is a special drug in that it is given before the N/V in anticipation of it

and as a prophylactic measure. It works best in the GI because it allows for a

degree metabolism that IV would not otherwise permit.

Respectfully,

Jeanetta Mastron CPhT BS

Pharm Tech Educator

cphtgenius@... wrote: Hi Jay,

Don't forget PR as a route of administration for antiemetics.

As to your question, I would say in a retail setting, we dispense more PO

antiemetics than any others.

--

Life should not be a journey to the grave with the intention of arriving safely

in an attractive and well-preserved body, but rather to skid in sideways,

champagne in one hand, strawberries in the other, body thoroughly used up,

totally worn out and screaming " WOO HOO - what a ride! "

-------------- Original message --------------

From: " jay62201 " <gundam9187@...>

do all antiemetic drugs come in PO or IV???

or should i say which is more common dosage form???

this question revolves around an new drug Emend that is antiemetic use

for postoperative nausea and vomiting

since its post-op wouldn't it be IV????