MS Trial Proposal for Irish Gov

May 13, 2004

Hi .. I have been meaning to post this for a while .. it is a part of

the proposal for a trial in Ireland for LDN and MS .. it is

interesting ..

All the Best

The autoimmune disease in which LDN is used most at present is

Multiple Sclerosis (MS). Dr Bihari currently has 384 patients with MS

in his medical care in a private practice setting in New York City.

These patients have been on LDN for an average of 2.5 years with a

range of 1 week to 19 years. The overall results of treatment with

this drug have been excellent. Only 3 of the 384 patients have shown

any attacks. To be more specific, one of these three, who started LDN

18 years ago, at the age of 22 in 1988, had one attack after 5 years

on the drug, 30 days after stopping it. The patient resumed LDN when

the attack appeared and has had none in the 13 years since. The

second of the three, a 41 year old woman had an episode of optic

neuritis which cleared in 4 weeks, after 18 months on LDN. The last

of the three was a patient who experienced an episode of numbness in

the left leg after 8 months on LDN, not previously present, which

cleared after 3 weeks. The other 381 patients with MS have had no

sign of disease activity since starting LDN.

Approximately 25% of the patients starting on 4.5mg LDN have

experienced an increase in spasticity. When the dose is reduced to

3mg the increase always clears. Overall, most patients with

significant spasticity , especially in the legs experience an overall

reduction in spasticity once the proper dose is achieved. The fatigue

associated with MS is generally reduced, sometimes substantially

after a few days on LDN. Rarely other MS symptoms are reduced while

on LDN, such as bladder spasticity and urinary incontinence and there

is an occasional patient who shows cognitive improvement if cognitive

impairment was present before treatment began.

About 20% of these patients were on avonex, beta-seron, copaxone,

novantrone or methotrexate before beginning LDN. Although no

recommendation is made about whether or not to continue these drugs

by Dr Bihari, only one has remained on copaxone with LDN for the 12

months she has been on LDN. The copaxone did not seem to interfere

with her LDN effect.

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