CR in human 36-year follow-up works

[Guest guest]

Hi All,

CR in a study of subjects in a follow-up 36 years works, it

seems.

Now, this is exciting information. 15% CR was highly effective,

whereas 50% CR was a thumbs-down.

J Gerontol A Biol Sci Med Sci. 2004 Aug;59(8):B789-95.

How much should we eat? The association between energy intake and

mortality in a

36-year follow-up study of Japanese-american men.

Willcox BJ, Yano K, Chen R, Willcox DC, BL, Masaki KH,

Donlon T,

Tanaka B, Curb JD.

..... We prospectively ... a large epidemiological study of

Japanese-American men. We followed 1915 healthy nonsmokers, aged 45-

68 years at

study onset, for 36 years. Twenty-four-hour recall of diet was

recorded at

baseline, and follow-up was for all-cause mortality. After adjustment

for age

and other confounders, there was a trend toward lower mortality in

the second

quintile of energy intake, suggesting that men who consumed 15% below

the group

mean were at the lowest risk for all-cause mortality. Increased

mortality was

seen with intakes below 50% of group mean. Thus, we observed trends

between low

energy intake and reduced risk for all-cause mortality in humans

until energy

intake fell to less than half the group mean, consistent with

previous findings

in other species.

PMID: 15345727 [PubMed - in process]

Cheers, Al Pater.