Levels of IGF-1

[Guest guest]

"Insulin-like Growth Factor 1 (IGF-1)

This is a hormone produced in the liver and bodily tissues that acquired its name because it has insulin-like activity in adipose tissue and has a structure that is very similar to that of proinsulin. Production is stimulated by human growth hormone and promotes cell growth of both normal and malignant cells [12] . Levels of IGF-1 peak at puberty and gradually decrease with age. At age 70, serum levels are half of the normal adult value of 200 ng/mL. IGF-1 has been found to play a role not only in prostate cancer but also childhood cancers, breast cancer, small cell lung cancer, melanoma, and pancreatic cancer [2] . Harvard researchers found that those men with high levels of IGF-1 of 300–500 ng/mL had four times the risk of prostate cancer than those with levels of 100–185 ng/mL [11] "

[2]. LeRoith D, et al. The role of the insulin-like growth factor-I receptor in cancer. ls New York Academy of Sciences 1995;766:402-8.

[11]. Chan JM, Stampfer MJ, Ma J, et al. Dairy products, calcium and prostate cancer risk in the Physician's Health Study. Am J Clin Nutr 2001;74:549-54.

[12]. Cohen P, et al. Insulin-like growth factors (IGFs), IGF receptors, and IGR-binding proteins in primary cultures of prostate epithelial cells. J Clin Endocrinol Metab 1991;73(2):401-7.

[Guest guest]

Hi JW:

Do we know whether CRON influences IGF-1? I checked the tables in

Hollosz's study and didn't see it listed.

Rodney.

--- In , " jwwright " <jwwright@e...>

wrote:

>

> " Insulin-like Growth Factor 1 (IGF-1)

> This is a hormone produced in the liver and bodily tissues that

acquired its name because it has insulin-like activity in adipose

tissue and has a structure that is very similar to that of

proinsulin. Production is stimulated by human growth hormone and

promotes cell growth of both normal and malignant cells [12] . Levels

of IGF-1 peak at puberty and gradually decrease with age. At age 70,

serum levels are half of the normal adult value of 200 ng/mL. IGF-1

has been found to play a role not only in prostate cancer but also

childhood cancers, breast cancer, small cell lung cancer, melanoma,

and pancreatic cancer [2] . Harvard researchers found that those men

with high levels of IGF-1 of 300-500 ng/mL had four times the risk of

prostate cancer than those with levels of 100-185 ng/mL [11] "

>

> [2]. LeRoith D, et al. The role of the insulin-like growth factor-I

receptor in cancer. ls New York Academy of Sciences 1995;766:402-

8.

>

> [11]. Chan JM, Stampfer MJ, Ma J, et al. Dairy products, calcium

and prostate cancer risk in the Physician's Health Study. Am J Clin

Nutr 2001;74:549-54.

>

> [12]. Cohen P, et al. Insulin-like growth factors (IGFs), IGF

receptors, and IGR-binding proteins in primary cultures of prostate

epithelial cells. J Clin Endocrinol Metab 1991;73(2):401-7.

[Guest guest]

--- In , " Rodney " <perspect1111@y...>

wrote:

> Hi JW:

>

> Do we know whether CRON influences IGF-1?

Hi All,

Yes, it beneficially does.

Cheers, Al Pater.

[Guest guest]

In a message dated 9/22/04 10:15:53 PM Eastern Daylight Time, jwwright@... writes:

IGF-1 has been found to play a role not only in prostate cancer but also childhood cancers, breast cancer, small cell lung cancer, melanoma, and pancreatic cancer

OTOH, you'd want IGF-1 to stimulate proliferation of immune system cells. After a certain age (~80?), pneumonia is the biggest killer, right? Not CVD or even cancer.

And how about possible cartilage production, if somebody has bad knees?

--

Ken

[Guest guest]

Hi Ken:

Yep. Immune system decline with age probably largely accounts for

the increased death rates with age from cancers; infections of many

types including flu, salmonella, e-coli, SARS, pneumonia and so on;

and septicemia. So, any hints about how we can maintain/improve

immune function, in addition to the immune system benefits from CR,

would be very helpful.

I know some herbal remedies claim to improve immune function. But is

there decent evidence to support the claims?

Rodney.

> In a message dated 9/22/04 10:15:53 PM Eastern Daylight Time,

> jwwright@e... writes:

>

> > IGF-1 has been found to play a role not only in prostate cancer

but also

> > childhood cancers, breast cancer, small cell lung cancer,

melanoma, and

> > pancreatic cancer

>

> OTOH, you'd want IGF-1 to stimulate proliferation of immune system

cells.

> After a certain age (~80?), pneumonia is the biggest killer, right?

Not CVD or

> even cancer.

>

> And how about possible cartilage production, if somebody has bad

knees?

>

> --

>

> Ken

[Guest guest]

Another controversial thing - I read a lot about it and come to the conclusion not to worry about it mainly because dairy is my main protein source.

Regards.

----- Original Message -----

From: bpinfo@...

Sent: Sunday, September 26, 2004 10:25 PM

Subject: Re: [ ] Levels of IGF-1

In a message dated 9/22/04 10:15:53 PM Eastern Daylight Time, jwwright@... writes:

IGF-1 has been found to play a role not only in prostate cancer but also childhood cancers, breast cancer, small cell lung cancer, melanoma, and pancreatic cancerOTOH, you'd want IGF-1 to stimulate proliferation of immune system cells. After a certain age (~80?), pneumonia is the biggest killer, right? Not CVD or even cancer. And how about possible cartilage production, if somebody has bad knees?-- Ken