Question for Duncan: Lactosucrose

[Guest guest]

Duncan,

The discussion thread below came form the Trying Low Oxalates list. Do

you know much about lactosucrose? I have problems handling dietary

oxalates, so I am looking for leads. As lactosucrose feeds gut

bacteria which get rid of oxalates, I thought you may have come upon

info.

Alobar

Hinyokika Kiyo. 2006 Sep;52(9):687-91.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?itool=pubmed_Abstract & db=pubmed & c\\

md=Display & dopt=pubmed_pubmed & from_uid=17040052

Related Articles, Links

[Effect of oral lactosucrose supplementation on human enteric

oxalate-degrading bacteria]

[Article in Japanese]

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\\

_Abstract & term=%22Takei+K%22%5BAuthor%5D

Takei K,

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\\

_Abstract & term=%22Akakura+K%22%5BAuthor%5D

Akakura K,

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\\

_Abstract & term=%22Ueda+T%22%5BAuthor%5D

Ueda T,

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\\

_Abstract & term=%22Mikami+K%22%5BAuthor%5D

Mikami K,

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed & cmd=Search & itool=pubmed\\

_Abstract & term=%22Ito+H%22%5BAuthor%5D

Ito H.

The Department of Urology, Graduate School of Medicine, Chiba

University School of Medicine.

A variety of oxalate-degrading bacteria including Oxalobacter

formigenes and some species of Bifidobacterium are known to colonize

the human intestinal tract. Oral lactosucrose supplementation promotes

the growth of Bifidobacterium in the human intestine. Therefore, we

investigated the effect of oral lactosucrose supplementation on

enteric oxalate-degrading bacteria in twelve healthy men (age ranging

from 25 to 39 years). Lactosucrose was orally administered 10 g daily

for 2 weeks without restriction of dietary intake. The total number of

oxalate-degrading bacteria in feces and the 24-hour urinary excretion

of oxalate were examined before and after lactosucrose

supplementation. The total number of oxalate degrading-bacteria was

significantly increased by lactosucrose supplementation (9.20 +/- 0.44

versus 9.77 +/- 0.46, p<0.05), although there was no significant

change in the urinary oxalate excretion. The oxalate

degrading-bacteria isolated from feces was biochemically identified as

Bifidobacterium adolescentis. In conclusion, oral supplementation of

10 g lactosucrose daily for 2 weeks was effective in multiplying

oxalate-degrading bacteria, but not in reducing urinary oxalate

excretion under free non-restricted dietary intake. In addition, it

was suggested that various species of Bifidobacterium were related to

degradation of oxalate in the human intestine.

Publication Types: * English Abstract

PMID: 17040052 [PubMed - indexed for MEDLINE]

+++++++++++++++++++++++

>I, too, have a hard time with the technical jargon used in research

>papers. What is lactosucrose and where does one get it? Also,

>since I am diabetic, would this not be a good idea??? I see

> " sucrose " and worry about blood sugar levels.

>

>Alobar

++++++++++++++++++++++++

Alobar,

This is what I found:

http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/pre_0326.shtml

LACTOSUCROSE

Lactosucrose is a trisaccharide comprised of D-galactose, D-glucose and

D-fructose. Lactosucrose is produced enzymatically by the enzymatic

transfer of the galactosyl residue in lactose to sucrose. Lactosucrose is

resistant to digestion in the stomach and small intestine. It is

selectively utilized by intestinal Bifidobacterium species resulting in

significant induction of growth of these bacteria in the colon. Therefore,

under physiological conditions, lactosucrose acts on the intestinal

microflora as a growth factor for Bifidobacterium species. Lactosucrose is

also known as 4G-beta-D-galactosylsucrose. It is widely used in Japan as a

dietary supplement and in functional foods, including yogurt. Lactosucrose

is being developed in the United States for similar uses.

If it is resistant to digestion, I doubt its presence would be a concern to

a diabetic and there is just a bit of suggestion by people trying to

develop a market for this product that it could help in daibetes. Just do

a search on lactosucrose and diabetes and see what comes up.

It looks like this product could help with

constipation: http://www.jpsfc.com/kaisi-jsfc/PDF/1/1-1-7.pdf

Most of the research has been done in Japan. Unfortunately, I don't see

any evidence that this product is sold in the US. I've written Larry

Newman at Kirkman to see if he can find out if there is a source for this

in the US,.

[Guest guest]

Sorry Alobar, I can't help you on the oxalates.

Duncan

On 30 Dec 2006 at 23:31, Coconut Oil

wrote:

>

> Posted by: " Alobar " Alobar@... wm_alobar

> Date: Sat Dec 30, 2006 1:57 pm ((PST))

>

> Duncan,

> The discussion thread below came form the Trying Low Oxalates list. Do

> you know much about lactosucrose? I have problems handling dietary

> oxalates, so I am looking for leads. As lactosucrose feeds gut

> bacteria which get rid of oxalates, I thought you may have come upon

> info.

>

> Alobar