Guest guest Posted May 24, 2002 Report Share Posted May 24, 2002 ALC is not a chelating agent. What it does is to let cells burn fat better rather than having to rely on sugar. Andy . .. . . . . > Is anyone using Acetyl-L-Carnitine as a supplement in an individual with > ASD? I came across this supplement and it looks interesting. Here is what > one of the vitamin selling sites had to say: > Acetyl carnitine enhances energy metabolism, especially the heart and brain. > It can increase muscle mass and convert body fat into energy. It metabolizes > energy in the cell mitochondria. Carnitine has been demonstrated to preserve > brain neuron function, and can improve mood, memory and cognition. Useful in > early stages of Alzheimer's disease. Carnitine is a very important brain > function stimulant that can boost immune function too. > > And another: > ALC also has the ability to cross into the brain where it acts as a powerful > antioxidant, preventing the deterioration of brain cells that normally > occurs with age. Because of this protective effect, ALC may be beneficial in > the prevention and treatment of free-radical mediated diseases, such as > Alzheimer's and Parkinson's disease. > > Does this mean it act as a chelation agent? > > Valeri > > > [Non-text portions of this message have b Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 22, 2004 Report Share Posted June 22, 2004 I believe it was Ames' research that led to Dr. Walford's recommendation of ALC and ALA: http://www.juvenon.com/articles.html Personally, I use the R(+) enantiomer along with ALC. The R(+) enantiomer is the naturally occuring form of LA in the body, and has different effects than the S(-) enantiomer that is also found in the racemic mix of standard ALA: http://www.r-lipoic.com/ I've not noticed anyting I could attribute to either supplement, but then again, rarely have I ever noticed any effect from any supplement (excepting caffeine!) >From: " citpeks " <citpeks@...> >Reply- > >Subject: [ ] acetyl-L-carnitine >Date: Tue, 22 Jun 2004 03:56:59 -0000 > >Waldford recommends supplementation with 120mg of alpha-lipoic acid, >and 500mg of acetyl-L-carnitine daily (BT120YD p167, p191), but had >question marks on p. 167 indicating that he was not totaly convinced >of their anti-aging effects. His comments on p. 191 about acetyl-L- >carnitine said that additional research was needed as of the date of >publication (2000). > >A recent article in Reader's digest mentioned that Dr. Ames was >recommending a similar combination for anti-aging. Below is a paper >published 2 years after BT120YD that seems to show that >hepatocellular ascorbate, which is supposedly a biomarker of aging, >was restored to more youthful by supplementation. > >I would appreciate knowing how many people in this group follow this >recommendation and also whether they feel any positive effects from >the supplements, particularly the acetyl-L-carnitine. > >Tony > >=== >Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):1870-5. > >Feeding acetyl-L-carnitine and lipoic acid to old rats significantly >improves metabolic function while decreasing oxidative stress. >Hagen TM, Liu J, Lykkesfeldt J, Wehr CM, Ingersoll RT, Vinarsky V, >Bartholomew JC, Ames BN. >Department of Biochemistry and Biophysics, Linus ing Institute, >Oregon State University, Corvallis, OR 97331, USA. > >Mitochondrial-supported bioenergetics decline and oxidative stress >increases during aging. To address whether the dietary addition of >acetyl-l-carnitine [ALCAR, 1.5% (wt/vol) in the drinking water] >and/or ®-alpha-lipoic acid [LA, 0.5% (wt/wt) in the chow] improved >these endpoints, young (2-4 mo) and old (24-28 mo) F344 rats were >supplemented for up to 1 mo before death and hepatocyte isolation. >ALCAR+LA partially reversed the age-related decline in average >mitochondrial membrane potential and significantly increased (P = >0.02) hepatocellular O(2) consumption, indicating that mitochondrial- >supported cellular metabolism was markedly improved by this feeding >regimen. ALCAR+LA also increased ambulatory activity in both young >and old rats; moreover, the improvement was significantly greater (P >= 0.03) in old versus young animals and also greater when compared >with old rats fed ALCAR or LA alone. To determine whether ALCAR+LA >also affected indices of oxidative stress, ascorbic acid and markers >of lipid peroxidation (malondialdehyde) were monitored. The >hepatocellular ascorbate level markedly declined with age (P = 0.003) >but was restored to the level seen in young rats when ALCAR+LA was >given. The level of malondialdehyde, which was significantly higher >(P = 0.0001) in old versus young rats, also declined after ALCAR+LA >supplementation and was not significantly different from that of >young unsupplemented rats. Feeding ALCAR in combination with LA >increased metabolism and lowered oxidative stress more than either >compound alone. > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 22, 2004 Report Share Posted June 22, 2004 I was supplementing for a while and didn't notice any differences in well- being etc. I gave it about 6 months before stopping. I''d be interested in knowing if others had any beneficial effects. on 6/21/2004 11:56 PM, citpeks at citpeks@... wrote: > Waldford recommends supplementation with 120mg of alpha-lipoic acid, > and 500mg of acetyl-L-carnitine daily (BT120YD p167, p191), but had > question marks on p. 167 indicating that he was not totaly convinced > of their anti-aging effects. His comments on p. 191 about acetyl-L- > carnitine said that additional research was needed as of the date of > publication (2000). > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 22, 2004 Report Share Posted June 22, 2004 I use l-carnitine almost every day. I see it as "burning" fat in the right places - a guess. It lowers my BP and that has to be good. Maybe it just aids transport. I usually take 250mg at 3AM when I get up to pee. Regards. ----- Original Message ----- From: citpeks Sent: Monday, June 21, 2004 10:56 PM Subject: [ ] acetyl-L-carnitine Waldford recommends supplementation with 120mg of alpha-lipoic acid, and 500mg of acetyl-L-carnitine daily (BT120YD p167, p191), but had question marks on p. 167 indicating that he was not totaly convinced of their anti-aging effects. His comments on p. 191 about acetyl-L-carnitine said that additional research was needed as of the date of publication (2000). Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 22, 2004 Report Share Posted June 22, 2004 I take R+ Lipoic and ALC daily and have done so for several years. I have not taken a holiday from it in all that time, so I can't compare to the lack of it. However, when I started, I noticed additional energy and mental clarity. This is recommended for Alzheimers and my father recently died of Alzheimers and my mother's sister also died of it. Before CRON and supplementation I was having a lot of concentration and memory problems. These are gone now. However, I have no proof that it's the R+ALA and ALC. I would have to take a holiday from them for several months to see - perhaps I will. Even then, they may be having beneficial effects that you can't detect. These are expensive supplements in the correct forms - more than a $1/day. The other list had a lot of discussion about them in the past and decided that it was important to take the R+ form of alpha-lipoic acid - and to take the R+ALA with the ALC, rather than ALC alone. There was a very convincing article in Discovery magazine on this a couple of years ago. > Waldford recommends supplementation with 120mg of alpha-lipoic acid, > and 500mg of acetyl-L-carnitine daily (BT120YD p167, p191), but had > question marks on p. 167 indicating that he was not totaly convinced > of their anti-aging effects. His comments on p. 191 about acetyl-L- > carnitine said that additional research was needed as of the date of > publication (2000). > > A recent article in Reader's digest mentioned that Dr. Ames was > recommending a similar combination for anti-aging. Below is a paper > published 2 years after BT120YD that seems to show that > hepatocellular ascorbate, which is supposedly a biomarker of aging, > was restored to more youthful by supplementation. > > I would appreciate knowing how many people in this group follow this > recommendation and also whether they feel any positive effects from > the supplements, particularly the acetyl-L-carnitine. > > Tony > > === > Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):1870-5. > > Feeding acetyl-L-carnitine and lipoic acid to old rats significantly > improves metabolic function while decreasing oxidative stress. > Hagen TM, Liu J, Lykkesfeldt J, Wehr CM, Ingersoll RT, Vinarsky V, > Bartholomew JC, Ames BN. > Department of Biochemistry and Biophysics, Linus ing Institute, > Oregon State University, Corvallis, OR 97331, USA. > > Mitochondrial-supported bioenergetics decline and oxidative stress > increases during aging. To address whether the dietary addition of > acetyl-l-carnitine [ALCAR, 1.5% (wt/vol) in the drinking water] > and/or ®-alpha-lipoic acid [LA, 0.5% (wt/wt) in the chow] improved > these endpoints, young (2-4 mo) and old (24-28 mo) F344 rats were > supplemented for up to 1 mo before death and hepatocyte isolation. > ALCAR+LA partially reversed the age-related decline in average > mitochondrial membrane potential and significantly increased (P = > 0.02) hepatocellular O(2) consumption, indicating that mitochondrial- > supported cellular metabolism was markedly improved by this feeding > regimen. ALCAR+LA also increased ambulatory activity in both young > and old rats; moreover, the improvement was significantly greater (P > = 0.03) in old versus young animals and also greater when compared > with old rats fed ALCAR or LA alone. To determine whether ALCAR+LA > also affected indices of oxidative stress, ascorbic acid and markers > of lipid peroxidation (malondialdehyde) were monitored. The > hepatocellular ascorbate level markedly declined with age (P = 0.003) > but was restored to the level seen in young rats when ALCAR+LA was > given. The level of malondialdehyde, which was significantly higher > (P = 0.0001) in old versus young rats, also declined after ALCAR+LA > supplementation and was not significantly different from that of > young unsupplemented rats. Feeding ALCAR in combination with LA > increased metabolism and lowered oxidative stress more than either > compound alone. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 22, 2004 Report Share Posted June 22, 2004 , Are these prescriptions or over the counter diet supplements. If you buy it over the counter or online what brand(s) have you found to be reliable? Thanks! --- In , " maxwell_mom " <mrobinso@m...> wrote: > I take R+ Lipoic and ALC daily and have done so for several years. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 23, 2004 Report Share Posted June 23, 2004 This is strictly OTC. Lately I have been buying Source Naturals Acetyl l-carnitine and R+ Lipoic. I have also bought Allergy Research brand Acetyl l- carnitine. I often but at Vitaminshoppe, but there is usually someplace cheaper. > > I take R+ Lipoic and ALC daily and have done so for several years. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 23, 2004 Report Share Posted June 23, 2004 I understand it does break down - but I thought moisture was much worse than heat. I tend to buy it a month or two at a time, so it's not stored too long - though who knows how long it is at the distributor. I've seen oils and probiotics come in cold packs, but not alpha lipoic. > Hi , > I have read that it is unwise to order R+Lipoic through the mail (especially > in the summer) because it is necessary to keep it refrigerated at all times > due to it being quite unstable otherwise. Can you (or anyone) give advice > concerning this? I would like to start taking it, but there is no local source. Do > you order yours from a source that sends it refrigerated? Any advice would be > greatly appreciated. > Sandy Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 29, 2010 Report Share Posted September 29, 2010 Start with one and see how she tolerates it. I think at that time I built my son up to 500 a day and then as he got older up to 1000 a day. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 6, 2010 Report Share Posted October 6, 2010 >>ONce when his lung issues > just weren't getting better I suggested that it was fungal to the doctor and > he prescribed an anti-fungal which cleared up his lungs. Great detective work! Asthma at my house was caused by yeast in the lungs. > We have been using nystantin again for a while. I know I have read here > about GSE and OLE. Which ones? What worked best at my house was the combination of biotin and GSE. OLE actually *increased* yeast. >>How long after > instituting a good yeast protocol may I begin the AC Protocol using ALA > only. I would get the yeast " reasonably under control " . Then you can start. Be prepared to increase the yeast protocol if/when required. Dana Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 7, 2010 Report Share Posted October 7, 2010 > Thanks Dana! Is there a particular brand of GSE and biotin I should buy? Nutribiotic GSE. I used Country Life biotin but there are other good brands also. > How much of each would I start a boy on who weighs about 135? I started 400mcg biotin and 1 drop GSE. Dana Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 16, 2011 Report Share Posted March 16, 2011 Can you please tell me about this? Would I look at this or Carnitine for low muscle tone? Wyatt has no lack of physical energy, but he does lack the ability to focus for periods of time. He is only 5 though. We are struggling with handwriting and I think it may be low muscle tone in his hands. Will the ALC address that as well? Higginson Wyatt (5yrs old HFASD/ADHD/OCD), (3yrs old NT), Trace (21 months NT) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 17, 2011 Report Share Posted March 17, 2011 Acetyl L Carnitine was great for my son's attention span and ability to concentrate. What helped with his hand writing was treating strep with augmentin. Many use OLE for this. Caryn > > Can you please tell me about this? Would I look at this or Carnitine for low muscle tone? Wyatt has no lack of physical energy, but he does lack the ability to focus for periods of time. He is only 5 though. We are struggling with handwriting and I think it may be low muscle tone in his hands. Will the ALC address that as well? > > > Higginson > Wyatt (5yrs old HFASD/ADHD/OCD), (3yrs old NT), Trace (21 months NT) > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 18, 2011 Report Share Posted March 18, 2011 How do you dose the ALC? We just started the OLE for Strep. I hope all of this helps him..Thanks! Higginson Wyatt (5yrs old HFASD/ADHD/OCD), (3yrs old NT), Trace (21 months NT) Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.