CR: amylin better than cholecystokinin?

[Guest guest]

Hi All,

For its effect on CR, is amylin better than cholecystokinin (CCK)?

It appears to be so based on the pdf-available (8). Being effective

at the physiological concentration for amylin should I think be

important. Yet, in our posts, CCK posts predominate

The other related references from this research group (1-6) are also

pdf-available.

1: Reidelberger RD, Haver AC, Arnelo U, DD, Schaffert CS,

Permert J.

Amylin Receptor Blockade Stimulates Food Intake in Rats.

Am J Physiol Regul Integr Comp Physiol. 2004 May 6 [Epub ahead of

print]

PMID: 15130879 [PubMed - as supplied by publisher]

2: Reidelberger RD, J, Fritzsch B, Hulce M.

Abdominal vagal mediation of the satiety effects of CCK in rats.

Am J Physiol Regul Integr Comp Physiol. 2004 Jun;286(6):R1005-12.

Epub 2003 Dec

30.

PMID: 14701717 [PubMed - in process]

3: Reidelberger RD, Castellanos DA, Hulce M.

Effects of peripheral CCK receptor blockade on food intake in rats.

Am J Physiol Regul Integr Comp Physiol. 2003 Aug;285(2):R429-37. Epub

2003 May

08.

PMID: 12738611 [PubMed - indexed for MEDLINE]

4: Reidelberger RD, Heimann D, Kelsey L, Hulce M.

Effects of peripheral CCK receptor blockade on feeding responses to

duodenal

nutrient infusions in rats.

Am J Physiol Regul Integr Comp Physiol. 2003 Feb;284(2):R389-98. Epub

2002 Oct

31.

PMID: 12414437 [PubMed - indexed for MEDLINE]

5: Reidelberger RD, Kelsey L, Heimann D, Hulce M.

Effects of peripheral CCK receptor blockade on gastric emptying in

rats.

Am J Physiol Regul Integr Comp Physiol. 2003 Jan;284(1):R66-75. Epub

2002 Oct

03.

PMID: 12388446 [PubMed - indexed for MEDLINE]

6: Reidelberger RD, Kelsey L, Heimann D.

Effects of amylin-related peptides on food intake, meal patterns,

and gastric

emptying in rats.

Am J Physiol Regul Integr Comp Physiol. 2002 May;282(5):R1395-404.

PMID: 11959682 [PubMed - indexed for MEDLINE]

8: Reidelberger RD, Arnelo U, Granqvist L, Permert J.

Comparative effects of amylin and cholecystokinin on food intake and

gastric

emptying in rats.

Am J Physiol Regul Integr Comp Physiol. 2001 Mar;280(3):R605-11.

PMID: 11171636 [PubMed - indexed for MEDLINE]

CCK is a physiological inhibitor of gastric emptying and food

intake. The pancreatic peptide amylin exerts similar actions, yet its

physiological importance is uncertain. Objectives were to compare the

dose-dependent effects of intravenous infusion of amylin and CCK-8 on

gastric emptying and food intake in rats, and to assess whether

physiological doses of amylin are effective. Amylin and CCK-8

inhibited gastric emptying with mean effective doses (ED(50)s) of 3

and 35 pmol x kg(-1) x min(-1) and maximal inhibitions of 60 and 65%,

respectively. Amylin and CCK-8 inhibited food intake with ED(50)s of

8 and 14 pmol x kg(-1) x min(-1) and maximal inhibitions of 78 and

69%, respectively. The minimal effective amylin dose for each effect

was 1 pmol x kg(-1) x min(-1). Our previous work suggests that this

dose increases plasma amylin by an amount comparable to that produced

by a meal. These results support the hypothesis that amylin acts as a

hormonal signal to the brain to inhibit gastric emptying and food

intake and that amylin produces satiety in part through inhibition of

gastric emptying.