Guest guest Posted May 29, 2004 Report Share Posted May 29, 2004 Hi All, Boron is an important micronutrient for osteoporosis via its affects on steroid hormones? It appears to be so. Vitamin D being a steroid was something that I was initially surprised to determine, when we published our one paper on it. We had previously delved into the role steroids play in cervical cancer. The role in estrogen level maintenance and avoidance of prostate cancer elevates the importance of boron, it seems to me. Oncol Rep. 2004 Apr;11(4):887-92. Dietary boron intake and prostate cancer risk. Cui Y, Winton MI, Zhang ZF, Rainey C, Marshall J, De Kernion JB, Eckhert CD. ...Boron affects human steroid hormone levels. ... The adjusted odds ratio was 0.46 (95% confidence interval: 0.21-0.98) for the highest quartile of boron intake comparing to the lowest quartile (P for trend = 0.0525). PMID: 15010890 [PubMed - in process] Medical Hypotheses Articles in Press Up-regulatory impact of boron on vitamin D function – does it reflect inhibition of 24-hydroxylase? Dusan Miljkovic, Natasha Miljkovic, Mark F. McCarty Summary Nutritional intakes of boron have been shown to lessen the adverse consequences of vitamin D deficiency in rodents. Pilot clinical studies suggest that this effect may be mediated, in whole or in part, by an increase in serum 25-hydroxyvitamin D. We propose that, in concentrations achievable with good diets, boron suppresses the activity of the microsomal enzyme 24-hydroxylase, chiefly responsible for catabolism of this steroid. This inhibition may reflect a direct interaction with the enzyme, or perhaps boron's ability to form a covalent complex with the product of its activity, 24,25-dihydroxyvitamin D. An up-regulatory impact of boron on 25-hydroxyvitamin D is potentially beneficial in light of the fact that the vitamin D status of many individuals is poor during winter months, and traditional supplemental doses of this vitamin are often too low to correct this problem. There is growing evidence that good vitamin D status – as reflected by 25-hydroxyvitamin D levels – may reduce risk for a host of prominent disorders; thus, boron may have the ability to potentiate this protection. Clinical studies also suggest that nutritional boron can up-regulate 17b-estradiol levels in women, including postmenopausal women receiving hormone replacement therapy. The catabolism of this hormone is achieved by microsomal enzymes catalyzing vicinal hydroxylations – a description that also applies to 24-hydroxylase. This suggests the more general hypothesis that nutritional boron can inhibit a range of microsomal enzymes which insert hydroxyl groups vicinal to existing hydroxyls in steroids – including the enzymes which catabolize estradiol and 25-hydroxyvitamin D. ......A more general impact on vicinal hydroxylations of steroids? Vitamin D is not the only bioactive steroid whose metabolism appears to be influenced by nutritional intakes of boron – several reports indicate that 17b-estradiol concentrations increase when boron in supplemented [18–21]. Notably, this effect is seen in post-menopausal women receiving hormone replacement therapy – suggesting that a reduction in estradiol catabolism (rather than synthesis) is responsible. The major routes of estradiol catabo-lism each involve introduction of a vicinal hydroxyl group – hydroxylations at the 2,4, or 16 position of 17b-estradiol, which is hydroxylated at the 3 and 17 positions. This raises the interesting possibility that boron may be a potent inhibitor for a range of mi-crosomal enzymes which catalyze the ins ertion of hydroxyl groups vicinal to existing hydroxyl groups in steroids – specific examples being 24-hydroxy-lase and the estradiol hydroxylases. Cheers, Alan Pater Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 29, 2004 Report Share Posted May 29, 2004 Yeah, I read that study a bit ago...seemed like boron is pretty available in many foods favored by CRers: red wine, dried fruit, nuts....., so I figured there might be some confounding influences of diet....but, perhaps there's more to it.. >From: " old542000 " <apater@...> >Reply- > >Subject: [ ] Boron >Date: Sat, 29 May 2004 20:41:43 -0000 > >Hi All, > > Boron is an important micronutrient for osteoporosis >via its affects on steroid hormones? It appears to be >so. Vitamin D being a steroid was something that I was >initially surprised to determine, when we published our one >paper on it. We had previously delved into the role steroids >play in cervical cancer. The role in estrogen level maintenance >and avoidance of prostate cancer elevates the importance of >boron, it seems to me. > > Oncol Rep. 2004 Apr;11(4):887-92. >Dietary boron intake and prostate cancer risk. >Cui Y, Winton MI, Zhang ZF, Rainey C, Marshall J, >De Kernion JB, Eckhert CD. > ...Boron affects human steroid hormone levels. ... >The adjusted odds ratio was 0.46 (95% confidence interval: >0.21-0.98) for the highest quartile of boron intake comparing >to the lowest quartile (P for trend = 0.0525). >PMID: 15010890 [PubMed - in process] > >Medical Hypotheses >Articles in Press > Up-regulatory impact of boron on vitamin >D function – does it reflect inhibition of 24-hydroxylase? >Dusan Miljkovic, Natasha Miljkovic, Mark F. McCarty > Summary Nutritional intakes of boron have been shown to lessen >the adverse consequences of vitamin D deficiency >in rodents. Pilot clinical studies suggest that this effect may be >mediated, in whole or in part, by an increase in serum >25-hydroxyvitamin D. We propose that, in concentrations achievable >with good diets, boron suppresses the activity of >the microsomal enzyme 24-hydroxylase, chiefly responsible for >catabolism of this steroid. This inhibition may reflect a >direct interaction with the enzyme, or perhaps boron's ability to >form a covalent complex with the product of its >activity, 24,25-dihydroxyvitamin D. An up-regulatory impact of boron >on 25-hydroxyvitamin D is potentially beneficial >in light of the fact that the vitamin D status of many individuals is >poor during winter months, and traditional >supplemental doses of this vitamin are often too low to correct this >problem. There is growing evidence that good >vitamin D status – as reflected by 25-hydroxyvitamin D levels – may >reduce risk for a host of prominent disorders; thus, >boron may have the ability to potentiate this protection. Clinical >studies also suggest that nutritional boron can up-regulate >17b-estradiol levels in women, including postmenopausal women >receiving hormone replacement therapy. >The catabolism of this hormone is achieved by microsomal enzymes >catalyzing vicinal hydroxylations – a description >that also applies to 24-hydroxylase. This suggests the more general >hypothesis that nutritional boron can inhibit a range >of microsomal enzymes which insert hydroxyl groups vicinal to >existing hydroxyls in steroids – including the enzymes >which catabolize estradiol and 25-hydroxyvitamin D. >.....A more general impact on vicinal >hydroxylations of steroids? >Vitamin D is not the only bioactive steroid whose >metabolism appears to be influenced by nutritional >intakes of boron – several reports indicate that >17b-estradiol concentrations increase when boron >in supplemented [18–21]. Notably, this effect is >seen in post-menopausal women receiving hormone >replacement therapy – suggesting that a reduction >in estradiol catabolism (rather than synthesis) is >responsible. The major routes of estradiol catabo-lism >each involve introduction of a vicinal hydroxyl >group – hydroxylations at the 2,4, or 16 position of >17b-estradiol, which is hydroxylated at the 3 and 17 >positions. This raises the interesting possibility that >boron may be a potent inhibitor for a range of mi-crosomal >enzymes which catalyze the ins ertion of >hydroxyl groups vicinal to existing hydroxyl groups >in steroids – specific examples being 24-hydroxy-lase >and the estradiol hydroxylases. > >Cheers, Alan Pater > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 30, 2004 Report Share Posted May 30, 2004 Hi All, For more on boron, see: http://www.nutrition.org/nutinfo/ 35 g prunes will meat the minimum requirement. Cheers, Alan Pater > Yeah, I read that study a bit ago...seemed like boron is pretty available in > many foods favored by CRers: red wine, dried fruit, nuts....., so I figured > there might be some confounding influences of diet....but, perhaps there's > more to it.. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 28, 2005 Report Share Posted August 28, 2005 My daughter's DAN doc prescribed boron for her, she tested low for it in her blood sample. She takes the mini-minerals liquid, tastes just like water. She's about 110 pounds & 11 ys old, and takes 1 tsp daily at bedtime. No negative effects at all, she just seems to get better and better with everything we add. She doesn't take Immunokids, but takes the Purekids and Child Essence multi. Anita, mom to Kaycie, 11 years old with AS > Hello everyone, > > Has anybody used boron ... any +ves, -ves or side > effects? Please let me know as my son's DAN doctor has > prescribed it instead of Immunokids. > > Thanks for all the help. > > Kirti > > > > ____________________________________________________ > Start your day with - make it your home page > http://www./r/hs Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 29, 2005 Report Share Posted August 29, 2005 I have a catalog from Bill Rich's minerals. They sell boron mineral water and this is what is says: " Boron is essential to bone metabolism and calcification of bones. Research indicates that Osteoporosis, arthritis and tooth decay can be prevented with boron. The parathyroid secretes a hormone that helps bones to grow, it contains more boron than any other part of the body. Boron is necessary for cartilage formation and repair, it affects calcium, magnesium and phosphorous levels. Memory and brain function can be improved with boron. Boron plays a role in regulating the hormones, especially estrogen. A deficiency can cause weak and fragile cell walls. Some research shows that boron improves libido. A partial list of of conditions that can be improved with Boron are: Arthritis Brittle bones Carpal tunnel Degenerative joint disease hormonal imbalance loss of libido memory loss muscle pain osteoporosis Receding Gums Weak cartilage Multiple Sclerosis (helps in repair of myelin) " Hope this helps. We did supplement with boron for awhile because my son had elevated levels of DDT. DDT causes a surge in estrogen - not good for boys. So we had to avoid soy and began supplementing with boron and a number other things to rid the body of estogen surge being caused by these environmental factors. Debbie > > Hello everyone, > > > > Has anybody used boron ... any +ves, -ves or side > > effects? Please let me know as my son's DAN doctor has > > prescribed it instead of Immunokids. > > > > Thanks for all the help. > > > > Kirti > > > > > > > > ____________________________________________________ > > Start your day with - make it your home page > > http://www./r/hs Quote Link to comment Share on other sites More sharing options...
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