Amino Acids & Diabetes

[Guest guest]

JW, seems that the the study you posted points to a valid connection.

Here's another. From what I've read, the reference to AA (or BCAA's)

has always meant the free form.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=pubmed & dopt=Abstra\

ct & list_uids=15094101

or http://snipurl.com/602m

Oral amino acid administration in patients with diabetes mellitus:

supplementation or metabolic therapy?

Aquilani R.

Service of Metabolic and Nutritional Pathophysiology, Salvatore Maugeri

Foundation, IRCCS, Medical Center of Montescano, Pavia, Italy.

direzione.montescano@...

Amino acids are essential for body protein synthesis. Moreover, they can

be used to produce energy within the cells. For protein turnover, normal

plasma amino acid concentration enhances proteolytic suppression by

insulin; furthermore, hyperaminoacidemia can stimulate protein synthesis

both in the presence of baseline insulin and in hyperinsulinemic

subjects with type 1 diabetes. In humans, the availability of amino

acids represents a factor more important than insulin in maintaining

protein synthesis in skeletal muscle. Among amino acids, branched-chain

amino acids exert an anabolic effect on heart protein metabolism, and

their uptake by the myocardium is increased by increasing their

circulating concentrations. An important aspect of branched-chain amino

acid metabolism in the heart (mainly in the ischemic heart) is that

branch-chain amino acid infusion can diminish myocardial lactate; in

this way, the inhibition of anaerobic energy phosphate caused by

accumulation of lactate can be overridden. Plasma amino acid

availability plays an important role in promoting protein synthesis and

in energy production, both in peripheral skeletal muscle and in the

myocardium.

PMID: 15094101 [PubMed - in process]