Re: Published Withdrawal Studies .... inc one byKutcher

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via BlackBerry by AT&TFrom: Jim <mofunnow@...>Sender: SSRI medications Date: Sun, 01 May 2011 15:37:00 -0500<SSRI medications >Reply SSRI medications Subject: Re: Published Withdrawal Studies .... inc one byKutcher I cannot believe that puke is running for office.On 5/1/2011 7:29 AM, jeremy9282 wrote:Selective serotonin reuptake inhibitordiscontinuation syndrome: proposed diagnostic criteria.K Black, C Shea, S Dursun,and S KutcherDepartment of Psychiatry, DalhousieUniversity, Halifax, NS. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1407715/ Seeletter "Selective serotoninreuptake inhibitors and discontinuation symptoms." involume 26 on page 152a. Thisarticle has been citedby other articles in PMC.AbstractOBJECTIVE: To establishspecific criteria by which selective serotonin reuptakeinhibitor (SSRI) discontinuation syndrome may be identified.DATA SOURCES: MEDLINE and PSYCHLIT databases were searchedfor case reports published from 1986 to 1997 inclusive, andreferences of relevant articles were also searched. STUDYSELECTION: Forty-six case reports of symptoms following thediscontinuation of fluoxetine, fluvoxamine, paroxetine orsertraline were selected. Three studies of SSRIdiscontinuation were also reviewed. DATA EXTRACTION:Demographic and treatment information, as well as thetiming, duration, number, nature and frequency ofdicontinuation symptoms. DATA SYNTHESIS: Paroxetine was mostfrequently implicated. The drug had been tapered in half ofthe cases. In some cases, symptom onset began during taper,whereas, in most cases, symptoms began within 1 to 3 days ofdrug discontinuation. Fifty-three different symptoms werereported, with dizziness being the most common. Other commonsymptoms were nausea or emesis, fatigue, headache, gaitinstability and insomnia. Shock-like sensations, paresthesiaand visual disturbances were the most rare. Withoutintervention, symptoms persisted for more than a week inhalf of the cases. In cases in which the SSRI was restarted,symptoms resolved within 72 hours. In some cases, withdrawalsymptoms recurred when the same SSRI was again discontinued.CONCLUSIONS: Findings were used to construct diagnosticcriteria for the SSRI discontinuation syndrome. Thesecriteria are 2 or more of the following symptoms developingwithin 1 to 7 days of discontinuation or reduction in dosageof an SSRI after at least 1 month's use, when these symptomscause clinically significant distress or impairment and arenot due to a general medical condition or recurrence of amental disorder: dizziness, light-headedness, vertigo orfeeling faint; shock-like sensations or paresthesia;anxiety; diarrhea; fatigue; gait instability; headache;insomnia; irri! tability; nausea or emesis; tremor; andvisual disturbances.FulltextFull text is available as a scannedcopy of the original print version. Get a printable copy (PDFfile) of the completearticle (1.7M), or click on a page imagebelow to browse page by page. Links to PubMed are alsoavailable for SelectedReferences. 255256257258259260261